Engineering design methods based on the assumption of crack growth and the application of fracture mechanics principles are commonly used in aerospace engineering for the design of aluminum structures. In aerospace manufacturing, surface shot peening is one of the most widely used techniques for improving the fatigue performance of structural components. This work reviews the effect of different shot peening coverage on surface integrity and fatigue crack growth (FCG) properties of 7B50-T7751 aluminum alloy. The shot peening was applied to middle-crack tension (MT) specimens with four kinds of peening coverage: 100%, 300%, 600% and 1000%, respectively. The results showed that shot peening treatment reduced specimen surface roughness, moreover, surface shot peening promoted a maximum microhardness increased by 28.1% and induced compressive residual stresses in order of −412 MPa compared to untreated specimens. FCG experiment results showed that the effect of shot peening coverage on da/dN-ΔK curves was quite limited at constant amplitude loading. With the increase of shot peening coverage from 100% to 1000%, the FCG rate decreases first and then increase. At 300% of surface shot peening coverage, the FCG rate is the lowest, which results in the longest fatigue crack growth life.