ArticleMAN'S RESPIRATORY RESPONSE DURING AND AFTER ACCLIMATIZATION TO HIGH ALTITUDEHermann Rahn, and Arthur B. OtisHermann RahnFrom the Department of Physiology and Vital Economics, School of Medicine and Dentistry, University of Rochester, and Arthur B. OtisFrom the Department of Physiology and Vital Economics, School of Medicine and Dentistry, University of RochesterPublished Online:01 Jun 1949https://doi.org/10.1152/ajplegacy.1949.157.3.445MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByAltitude physiology then (1921) and now (2021): Meat on the bonesPeter D. Wagner15 November 2021 | Physiological Reviews, Vol. 102, No. 1Fetal growth, high altitude, and evolutionary adaptation: a new perspectiveKathryn Wilsterman and Zachary A. Cheviron18 August 2021 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 321, No. 3Physiologically driven, altitude-adaptive model for the interpretation of pediatric oxygen saturation at altitudes above 2,000 m a.s.l.Laura Tüshaus,* Monica Moreo,* Jia Zhang, Stella Maria Hartinger, Daniel Mäusezahl, and Walter Karlen16 September 2019 | Journal of Applied Physiology, Vol. 127, No. 3Current paradigms and new perspectives on fetal hypoxia: implications for fetal brain development in late gestationCharles E. Wood and Maureen Keller-Wood21 June 2019 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 317, No. 1Hypoxemia, oxygen content, and the regulation of cerebral blood flowRyan L. Hoiland, Anthony R. Bain, Mathew G. Rieger, Damian M Bailey, and Philip N. Ainslie1 March 2016 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 310, No. 5Cerebral Blood Flow at High AltitudeHigh Altitude Medicine & Biology, Vol. 15, No. 2Regional cerebral blood flow in humans at high altitude: gradual ascent and 2 wk at 5,050 mC. K. Willie, K. J. Smith, T. A. Day, L. A. Ray, N. C. S. Lewis, A. Bakker, D. B. Macleod, and P. N. Ainslie1 April 2014 | Journal of Applied Physiology, Vol. 116, No. 7Physiology in Medicine: Acute altitude exposure in patients with pulmonary and cardiovascular diseaseLeigh M. Seccombe, and Matthew J. Peters1 March 2014 | Journal of Applied Physiology, Vol. 116, No. 5The physiological legacy of the Fenn, Rahn, and Otis schoolJohn B. West15 November 2012 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 303, No. 10Operation Everest IIHigh Altitude Medicine & Biology, Vol. 11, No. 2Iron Homeostasis and Its Interaction with Prolyl HydroxylasesAntioxidants & Redox Signaling, Vol. 12, No. 4The Rahn–Otis Discovery of Hypoxic Ventilatory DeclineHigh Altitude Medicine & Biology, Vol. 6, No. 4Acclimatization to High Altitude: Truths and MisconceptionsHigh Altitude Medicine & Biology, Vol. 4, No. 4Hypoxic Ventilatory Response Changes of Men and Women 6 to 7 Days after Climbing from 2100 m to 4350 m Altitude and after DescentHigh Altitude Medicine & Biology, Vol. 4, No. 3Improving Oxygenation at High Altitude: Acclimatization and O 2 EnrichmentHigh Altitude Medicine & Biology, Vol. 4, No. 3Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humansKojiro Ide, Michael Eliasziw, and Marc J. Poulin1 July 2003 | Journal of Applied Physiology, Vol. 95, No. 1Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlandersPeter D. Wagner, Mauricio Araoz, Robert Boushel, José A. L. Calbet, Birgitte Jessen, Göran Rådegran, Hilde Spielvogel, Hans Søndegaard, Harrieth Wagner, and Bengt Saltin1 April 2002 | Journal of Applied Physiology, Vol. 92, No. 4Ventilatory responses to acute and chronic hypoxia in mice: effects of dopamine D2 receptorsK. A. Huey, M. J. Low, M. A. Kelly, R. Juarez, J. M. Szewczak, and F. L. Powell1 September 2000 | Journal of Applied Physiology, Vol. 89, No. 3Cerebral vasomotor reactivity at high altitude in humansGerard F. A. Jansen, Anne Krins, and Buddha Basnyat1 February 1999 | Journal of Applied Physiology, Vol. 86, No. 2 More from this issue > Volume 157Issue 3June 1949Pages 445-462 Copyright & PermissionsCopyright © 1949 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1949.157.3.445PubMed18151752History Received 21 February 1949 Published online 1 June 1949 Published in print 1 June 1949 Metrics