Single-phase-to-ground fault in low-current grounding systems represents a serious public safety concern. Low-voltage (LV) sensors, with their growing maturity, can now monitor multiple points of the mid-voltage (MV) distribution network. This paper proposes a new method for identifying single-phase-to-ground line faults and locating them using LV sensors deployed on the LV side of distribution transformers. We analyze the characteristics of the negative-sequence signal on the LV side after a single-phase grounding fault occurs on the MV side. The negative-sequence current can distinguish between fault and non-fault lines. By setting the ratio coefficient of negative-sequence voltage and positive-sequence voltage, we can use multi-point collaborative calculation and comparison to determine the section of the fault point. We consider the unbalanced load on the LV side and the special case of a fault point on one end of the line. Through simulation of combined MV and LV distribution systems in MATLAB software and dynamic model experiments, we verify that the proposed method has good robustness and accuracy. Monitoring the status information of the MV distribution network through LV sensors has great potential in practical application and implementation for realizing the fault detection of low-current grounding systems.