Municipal sludge is difficult to treat and dispose of because of its high moisture content (MC) and volume. In this study, a novel dewatering method that utilizes ultrahigh pressure filtration (UHPF) and thin-cake-press (TCP) coupled with microwave pretreatment was proposed to reduce the MC of sludge cake. The influence of microwave contact time (MCT), microwave intensity (MI), initial MC of sludge, dewatering time, applied pressure and sludge weight (Ws) on the MC of a sludge cake was investigated by the single-factor experiment. Moreover, a water discharge path model was developed to understand the dewatering mechanism and explain the relationship between thickness and MC of the cake. The key factors affecting the MC of the cake were explored by the orthogonal experiment. The experimental results showed that microwave irradiation could effectively improve the dewatering performance and reduce the MC of the sludge cake. The MC of the cake reached its lowest value of 28% at MCT of 120 s and MI of 400 W, which is much lower than the value obtained by the traditional dewatering method. Among the parameters mentioned above, Ws has the most significant influence on MC because a large amount of sludge leads to a thicker cake, which seriously hampers the flow of filtrate and inevitably increases the MC of the cake.