Optimal characterization is assumed to provide the best solution for the designed cost function among the possible solutions within the specified range. These processes can take a long time depending on the applications and computer hardware used. Here, the optimization process is supported by ANN modeling in order to shorten the current optimization processes as much as possible. For this purpose, the selection of design parameters of the bowtie patch antenna (BPA) is presented as a multi-dimensional, multi-objective modeling-supported design optimization problem. The operating frequency of the proposed antenna is 28 GHz, which is the standard for millimeter wave band and 5G technologies. To overcome this challenging design optimization, a new, fast and powerful optimization algorithm was used by modifying the non-dominant sorting genetic algorithm (NSGA)-III, and the optimal characterization of the microwave antenna design was achieved. Although the proposed method gives the same results compared to the existing process, it takes much less time. Therefore, it is possible to shorten the process and reduce costs without the need for extra applications or hardware. As a whole, the proposed design optimization process is an efficient, fast and reliable solution for all design problems.