Microstomia is the term used to describe a condition of reduction in the size of the oral aperture which can be either acquired or congenital. Patients with microstomia have restricted mouth opening which causes difficulty in inserting and removing the prosthesis as a whole. Prosthetic rehabilitation of such patients is a challenge. Steps in the fabrication of complete denture like impression making and denture processing are modified in sectional complete denture. This enables the patient to use them in sections without much difficulty. This clinical report describes prosthodontic management of a completely edentulous patient with microstomia developed due to oral sub mucous fibrosis. Sectional maxillary denture was fabricated using a sectional impression tray technique. With the use of post and tubes in the palatal region, the denture could be easily inserted and removed in two parts. Mandibular denture was fabricated by the conventional method.