The discovery of triboelectric nano-generators (TENGs) has resulted in the invention and development of self-powered electronics and devices. TENGs offer numerous benefits including their portability, affordability, and sustainable micro-scale energy harvesting in the realm of self-powered sensors and portable devices. TENGs have the capability to function as an autonomous power source. Integration of TENG with electrochemical processes can facilitate self-powered electrochemistry such as water splitting (or electrolysis) for H2 production, thereby eliminating the requirement for an external power supply. This review primarily centers on the operation and the recent advancements of TENGs in self-powered water-splitting for clean and environment-friendly H2 production utilizing renewable energy sources including wind, wave, and low-scale mechanical energy. The concept of conducting water-splitting without reliance on an external power source holds the potential for significant use in the field of clean and green H2 production with cost advantages, sustainability, and other environmental benefits.