High cyclic fatigue (HCF) behavior of an AA2139 alloy belonging to Al–Cu–Mg–Ag system in T6 and T840 conditions was examined. The T840 treatment involving cold rolling with a 40% reduction prior to peak ageing provides an increase in tensile strength compared with the T6 condition. However, fatigue lifetime for two material conditions was nearly the same since there is weak effect of thermomechanical processing on micro-mechanisms of crack initiation and growth.