Introduction External beam radiotherapy performance has been increased by the emergence of state-of-the-art techniques, which improve local irradiation while preserving surrounding organs. They require consistent Quality Assurance (QA) programs, supported by Electronic Portal Imaging Devices and Dynalog files. Nevertheless, they do not enable accurate dose-monitoring during online delivery sessions. In the framework of the INSPIRA project, the DAMe group, in collaboration with the Radiotherapy Department of CHUG, is developing an innovative Transparent Detector for Radiotherapy (TraDeRa). The beam modulated by the Multileaf Collimator will be monitored ahead of the patient, in real-time, without dead zone. Material and methods Current version of this detector is a 1:4 scale prototype, partially instrumented. Basically, it consists in a matrix of ionization chambers. First, we measured the dose with a PTW 0.3 cc ionization chamber, in standard conditions, with and without embedding TraDeRa, to quantify detector-induced attenuation. Then, the detector was irradiated using a 14 square cm beam. Inhouse front-end electronics allows the amplitude of each pulse to be extracted, providing dose rate at the pulse scale. Finally, TraDeRa was irradiated with a 3 mm sliding slit. A real-time map of the signal every 50 ms is provided. Results The detector induces a 0.6% attenuation of the beam. Global accuracy and stability of TraDeRa was verified. We highlighted dose rate noticeable variations during the irradiation. Amplitudes of delivered pulses vary around 5% of the mean value, and up to 25% for the first pulse. Accurate monitoring of leaf position was obtained. The interleaf leakage appears clearly and represents a non-negligible contribution to the dose. Recently, a specific integrated circuit has been designed by the LPSC microelectronics group. It represents a key-step for the forthcoming embedded electronics. Conclusion The current version of TraDeRa already shows promising results for IMRT-QA. It is quite transparent so that it does not hinder the irradiation, while keeping the beam upstream of the patient under constant control. It will offer both suitable precision on 2D-beam characterization and real-time measurements at the pulse scale or every 50 ms. The development of the final prototype, with all embedded electronics, is in progress and is expected by the end of 2013.
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