Microchannel technology rapidly established itself as a practicable solution to the problem of the removal of extremely concentrated heat generation in present-day cooling fields. By implementing a better design structure, altering the working fluids and flow conditions, using various materials for fabrication, etc., it is possible to increase the heat transfer performance of microchannels. Two parameters that affect how well a microchannel transfers heat were only recently coupled, and the complicated coupling of the parameter that affects how well a microchannel sink transfers heat is still not well understood. The newest industrial developments, such as micro-electro-mechanical systems, high performance computing systems, high heat density generating future devices, such as 5G/6G devices, fuel cell power plants, etc., all present thermal challenges that require the use of microchannel technology. In this paper, single-phase flow in microchannels of various sizes, with or without microinserts, is described in terms of its thermal-fluid flow properties, including fluid flow characteristics and heat transfer characteristics considering the compound effects of variations of channel size and addition of microinserts. The trials were carried out using distilled water that had thermo-physical characteristics that varied with temperature. A microchannel with microinserts was developed for managing the high heat generation density equipment. The fluid flow and heat transfer characteristics are explored and analyzed for Reynolds numbers ranges from 125 to 4992, for 1 mm channel size, and from 250 to 9985, for 2 mm channel size. The cooling performance criteria are pressure drop characteristics, heat transfer characteristics, and overall performance, whereas the testing parameters were chosen for the variations in channel size and the addition of microinserts. The influence of inserting microinserts on microchannels is discussed. Results suggest that by inserting microinserts, the performance of the heat transfer of microchannels is significantly improved and, also, fluid flow resistance is increased. The criteria of the thermal performance factor are employed to assess the overall performance of the microchannel. Significant intensification of heat transfer is observed with indication that the addition of microinserts to microchannels and reduction in channel sizes exhibited improved overall performance.