In the present study, a mathematical model is developed by combining the Tiwari-Das nanofluid formulation with the Eringen micro-morphic model to simulate the thermo-solutal natural convection chemically reacting micropolar nanofluid flow from a permeable stretching surface with non-uniform heat source/sink effects. The transformed ordinary differential equation boundary value problem features linear momentum, angular momentum, energy and species conservation boundary layer equations with appropriate boundary conditions. This ninth order nonlinear system is solved with Runge-Kutta 45 Fehlberg method. The influence of the effect of the emerging parameters on the flow characteristics are visualized and tabulated. It is observed that increasing volume fraction decreases velocity whereas it elevates microrotation, temperature and nanoparticle concentration. Nanoparticle concentration are elevated for stronger destructive chemical reaction effect whereas they are suppressed with constructive chemical reaction. With greater micropolar boundary condition parameter, the velocity is elevated, microrotation but reduces temperature and thermal boundary layer thickness. Increasing nanoparticle volume fraction enhances both skin friction and couple stress but marginally reduces the Nusselt number. Finally, Au-water micropolar nanofluids achieve the highest skin friction and couple stress magnitudes, then Ag-water and finally Cu-water. Validation of solutions with earlier non-reactive studies in the absence of nanoparticle mass transfer are included.
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