In this study, a green stability indicating chromatographic methods were developed and validated for the quantitative determination of tenofovir alafenamide in the presence of its degradation products in bulk powder as well as in dosage forms. The first method was micellar UPLC in which separation was achieved on kinetex ® 1.7μm HILIC 100A, LC column using an ecofriendly micellar mobile phase consisting (0.05M sodium dodecyl sulphate and 0.05M sodium dihydrogen phosphate, (pH5.5) and 10% 1-propanol (70:30) at a flow rate of 1mLmin-1 with a UV detection at 210nm. The second method depended on HPTLC method performed on HPTLC plates pre-coated with silica gel 60F254 using a mobile phase consisting of n-butanol-acetic acid (7:3, v/v) and detection at 260nm. Tenofovir alafenamide was subjected to stress conditions including alkaline and acidic degradation. Beer' law was obeyed over the concentration range of 1-18μgmL-1 and 0.1-4μg/spot for micellar UPLC and HPTLC methods, respectively. Both methods are successfully applied to the analysis of the drug in its tablets and validated according to ICH guidelines. In addition, their greenness was assessed using three different tools indicating their least hazardous effect on the environment.