Mg Of Iron Research Articles

The Effectiveness of a Nursing Care Program Supplemented with Iron Intake on Anemia and Fatigue in Cancer Patients Undergoing Chemotherapy

Background: Fatigue is one of the most common complications of cancer. Anemia can be one of the most prevalent causes of fatigue in cancer patients. Objectives: The present study aimed to explore the effectiveness of a nursing care program supplemented with iron intake on the anemia and fatigue in cancer patients undergoing chemotherapy. Methods: The present study was conducted in a quasi-experimental design on two groups of 90 cancer patients in selected hospitals. The participants were selected via convenience sampling and were randomly assigned to the control and intervention groups. Before the intervention, the Functional Assessment of Cancer Therapy - Anemia (FACT-An) was completed by the patients in both groups. The patients in the control group did not receive any special care other than receiving 150 mg of iron daily. However, the patients in the intervention group received 150 mg of iron daily and attended a nursing care program with four individual training sessions (one session per week). Follow-up was performed for three weeks, and the questionnaire was completed again by the participants in both groups. The collected data were analyzed using the independent samples t-test, paired-samples t-test, and chi-square test in SPSS software (version 22). The data analysis process was performed at a significance level of less than 0.05. Results: The mean scores for the patient hemoglobin in the intervention and control groups after the intervention were 11.84 ± 0.58 and 11.10 ± 67.29, showing a significant increase in favor of the intervention group (P < 0.001). Furthermore, the results of the independent samples t-test showed that the mean score of fatigue for the patients in the intervention group (29.37 ± 9.56) was significantly lower than that of the participants in the control group (47.55 ± 11.22) (P < 0.001). Conclusions: The present study showed that the implementation of a nursing care program for cancer patients receiving iron supplementation positively affects iron-related blood parameters and fatigue among these patients. Therefore, to control cancer patients' fatigue, medical staff must pay special attention to these training and care programs supplemented with iron intake.

Iron Absorption is Greater from Apo-Lactoferrin and is Similar Between Holo-Lactoferrin and Ferrous Sulfate: Stable Iron Isotope Studies in Kenyan Infants

Whether lactoferrin (Lf) binds iron to facilitate its absorption or to sequester iron from potential enteropathogens remains uncertain. Bovine Lf is added to many infant formulas, but previous studies in infants reported that Lf had no effect on or inhibited iron absorption. The effects of the apo (iron-free) or the holo (iron-loaded) forms of Lf on iron absorption are unclear. Our objective was to compare iron absorption from a maize-based porridge containing: 1) labeled ferrous sulfate (FeSO4) alone; 2) labeled FeSO4 given with bovine apo-Lf; and 3) intrinsically labeled bovine holo-Lf. In a crossover study, we measured iron absorption in Kenyan infants (n=25; mean±SD age 4.2±0.9 months; mean±SD hemoglobin 109±11g/L) from maize-based test meals containing: 1) 1.5mg of iron as 54Fe-labeled FeSO4; 2) 1.42mg of iron as 58Fe-labeled FeSO4, given with 1.41g apo-Lf (containing 0.08mg iron); and 3) 1.41g holo-Lf carrying 1.5mg iron as 57Fe. The iron saturation levels of apo- and holo-Lf were 0.56% and 47.26%, respectively primary outcome was fractional iron absorption (FIA), assessed by erythrocyte incorporation of isotopic labels. The FIA from the meal containing apo-Lf+FeSO4 (geometric mean, 9.8%; -SD and +SD, 5.4% and 17.5%) was higher than from the meals containing FeSO4 (geometric mean, 6.3%; -SD and +SD, 3.2% and 12.6%; P=0.002) or holo-Lf (geometric mean, 5.0%; -SD and +SD, 2.8% and 8.9%; P <0.0001). There was no significant difference in FIA when comparing the meals containing holo-Lf versus FeSO4 alone (P=0.24). The amount of iron absorbed from holo-Lf was comparable to that of FeSO4, and the addition of apo-Lf to a test meal containing FeSO4 significantly increased (+56%) iron absorption. These findings suggest that Lf facilitates iron absorption in young infants. Because Lf binds iron with high affinity, it could be a safe way to provide iron to infants in low-income countries, where iron fortificants can adversely affect the gut microbiome and cause diarrhea. This study was registered at clinicaltrials.gov as NCT03617575.

Development and nutritional evaluation of local ingredients-based supplements to treat moderate acute malnutrition among children aged below five years: A descriptive study from rural Wolaita, Southern Ethiopia.

In Ethiopia, moderate acute malnutrition (MAM) is a persistent public health problem. The current management approaches for MAM among children are counseling in food‐secure settings and food supplementation in chronically food‐insecure areas. The objective of this study was to develop a local ingredients‐based supplement (LIBS) for treating MAM among children. Collection of food ingredients (pumpkin seed, amaranth grain, flaxseed, peanut, and emmer wheat) was made. Sorting, soaking, drying, roasting, and milling of ingredients were done. Nutrient analysis was done using triplicate measurements of each nutrient. One‐way ANOVA was used to analyze differences in means with ± standard deviation of nutrient measurements among the supplements. The nutrient content of four developed LIBS ranged from 20.3 g to 22.5 g for protein, 29.3 g to 33.5 g for fat, 509.5 kcal to 570.0 for kcal, 6.0 g to 8.5 g for fiber, 2.8 g to 3.7 g for moisture, and 2.1 g to 4.3 g for ash. The mineral and antinutrient components ranged from 75.6 mg to 115.6 mg for calcium, 473.1 mg to 570.2 mg for potassium, 79.3 mg to 114.4 mg for sodium, 4.1 mg to 5.6 mg for zinc, 8.2 mg to 10.2 mg for iron, 442.6 mg to 470.4 mg for phosphorous, and 2.1 mg to 4.3 mg for phytate. The LIBS with the highest portion of pumpkin seed had significantly highest amounts of protein, fat, calories, iron, zinc, and potassium. The results found were within the recommended range of required nutrients for the treatment of children with MAM. Therefore, LIBS may be used for the management of children with MAM.

Effects of iron on intestinal development and epithelial maturation of suckling piglets

The purpose of the present study was to discover the effects of iron on the intestinal development and epithelial maturation of suckling piglets. Twenty-seven newborn male piglets from 9 sows (3 piglets per sow), with similar body weight, were selected. The 3 piglets from the same sow were randomly divided into 1 of the 3 groups. The piglets were orally administrated with 2 mL of normal saline (CON group) or with 25 mg of iron by ferrous sulfate (OAFe group; dissolved in normal saline) on the 2nd, 7th, 12th, and 17th day, respectively, or intramuscularly injected with 100 mg of iron by iron dextran (IMFe group) on the 2nd day. The slaughter was performed on the 21st day and intestinal samples were collected. Compared with the CON group, iron supplementation significantly increased the length (P < 0.001), weight (P < 0.001), relative weight (P < 0.001), and the length:weight ratio (P < 0.001) of the small intestine in both OAFe and IMFe groups. The villus height (P < 0.001), crypt depth (CD) (P < 0.001), villus width (P = 0.002), and surface area (P < 0.001) in the jejunum of IMFe and OAFe piglets were also greater than those in CON piglets. The mRNA expression of trehalase (Treh; P = 0.002) and sucrase isomaltase (Sis; P = 0.043), markers of epithelial maturation, increased in OAFe and IMFe piglets, respectively. Moreover, enterocyte vacuolization, observed in fetal-type enterocyte, was reduced in OAFe and IMFe piglets, compared with CON piglets. However, no significant difference in the expression of the target genes of wnt/β-catenin signaling pathway was observed. The results indicated that both oral administration and intramuscular injection with iron promoted intestinal development and epithelial maturation in suckling piglets and that the effects of iron may be independent of wnt/β-catenin signaling.

Efficacy and safety of high-dose intravenous iron as the first-choice therapy in outpatients with severe iron deficiency anemia.

Asymptomatic severe iron deficiency anemia is a common finding in subjects admitted to the outpatient anemia clinic. Although the condition can be easily be reversed with intravenous iron (IVI) therapy and several guidelines have suggested a restrictive threshold for using transfusion in hemodynamically stable patients, transfusion is often the rule in clinical practice. This study describes clinical practice results of IVI therapy without transfusion. In this multicenter retrospective observational study, data of severely anemic outpatients treated only with high-dose IVI with ferric carboxymaltose were collected. Inclusion criteria were hemoglobin (Hb) level of less than 7.0 g/dL and ferritin level of less than 30 ng/mL or mean corpuscular volume of less than 75 fL. Overall, 303 patients referred to the anemia clinic mainly from primary health care centers (46.2%) or the emergency department (28.7%) met the inclusion criteria. Median (interquartile range [IQR]) age was 47 (37-62) years and 84.5% were female. The median (IQR) Hb concentration at first visit was 6.5 (6.1-6.8) g/dL, 64 patients (21.1%) presented with a Hb level of less than 6.0 g/dL at diagnosis, and 11 of them (3.6%) had extreme anemia (Hb ≤ 5 g/dL). Gynecologic and gastroenteric bleeding were the main cause. After a mean IV administration of 1500 mg of iron, the Hb increased by a median of 5.7 g/dL. Thirteen patients experienced only mild side effects. In chronic very severe sideropenic anemias, third-generation IVI is effective and safe for quick correction and avoidance of red blood cell transfusion. These results suggest that more specific guidelines for this clinical setting are warranted.

Conversion of haemodialysis patients from iron sucrose to iron isomaltoside: a real-world experience

BackgroundAnaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment of anaemia in these patients. The comparative efficacy and risk of adverse events with IV iron preparations have been assessed in only a few trials.MethodsThis was a retrospective observational study in 2 centres designed to compare the safety and efficacy of iron sucrose (IS-Venofer®) versus iron isomaltoside (IIM-Diafer®) in haemodialysis patients. The study included patients currently on dialysis and receiving Venofer who were switched to Diafer® and monitored for at least 12 months for each iron preparation.ResultsA total of 190 patients were included and had a mean age of 65.8 years (SD ± 15.5). Non-inferiority was confirmed with no change in mean haemoglobin per mg of iron administered over a 12-month period.In total there were 41,295 prescriptions of iron isomaltoside and 14,685 of iron sucrose with no difference in the number of reported adverse events during the study period (7 each, none were severe).There was a statistically significant effect on Hb over time after conversion, including adjustment for multiple comparisons. There were significant improvements in ferritin over time, which remained at 6 months (P < 0.01). The weekly iron dose was similar after adjustment (P = 0.02). The EPO dose did not differ significantly after month 0 in patients switched to IIM.ConclusionsThis study demonstrates the comparative safety and efficacy of iron isomaltoside versus iron sucrose, with similar dosing schedules in dialysis patients. Iron isomaltoside is non-inferior to iron sucrose in maintaining Hb in patients on regular haemodialysis/haemodiafiltration with no difference in the number of reported adverse events.

Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation

The aim of this study was to determine how folate and iron deficiency, and the subsequent supplementation of rats’ diet with these nutrients, affects Slc19a1and Tfr2 gene expression and the metabolism of folate and iron. After 28 days of iron–folate deficiency 150 female rats were randomized into five experimental groups receiving a diet deficient in folic acid (FA), an iron-supplemented diet (DFE), an iron-deficient diet supplemented with FA (DFOL), a diet supplemented with iron and FA (FEFOL), and a diet deficient in iron and FA (D); there was also a control group (C). Samples were collected on days 2, 10, and 21 of the experiment.After two days of supplementation, Tfr2 mRNA level were 78 % lower in the DFE group than in the C group (p < 0.05); after 10 days, TfR2 levels in the FEFOL group were 82 % lower than in the C and the DFE group (p < 0.01). However, we did not find any differences at the protein level at any time-point. Hepcidin concentrations were higher in the DFE and the DFEFOL groups than in the D group after 21 days of supplementation (p < 0.01). Transcript and protein abundance of Slc19a1 gene did not differ between the groups at any time-point.Iron metabolism was affected by iron and folate deficiency and subsequent supplementation with these micronutrients, but TFR2 protein was not involved in the regulatory mechanism. Hepcidin expression can be are upregulated after 21 days of supplementation with 150 mg of iron/ kg of diet.

The Effect of Lactobacillus plantarum 299v on Iron Status and Physical Performance in Female Iron-Deficient Athletes: A Randomized Controlled Trial.

Iron is an essential micronutrient for oxygen transport and mitochondrial metabolism and is critical for physical performance. Compromised iron stores are more commonly found among athletes, and females are especially at risk. Iron deficiency is generally treated using oral iron supplements. However, only a small proportion of ingested iron is absorbed, necessitating higher intakes, which may result in adverse side effects, reduced compliance, and inefficient repletion of iron stores. The probiotic strain Lactobacillus plantarum 299v (Lp299v) significantly increases intestinal iron absorption in meal studies. The present study was conducted to explore the effects of 20 mg of iron with or without Lp299v on iron status, mood state, and physical performance. Fifty-three healthy non-anemic female athletes with low iron stores (ferritin < 30 μg/L) were randomized, and 39 completed the study. Intake of Lp299v with iron for four weeks increased ferritin levels more than iron alone (13.6 vs. 8.2 µg/L), but the difference between the groups was not significant (p = 0.056). The mean reticulocyte hemoglobin content increased after intake of Lp299v compared to control (1.5 vs. 0.82 pg) after 12 weeks, but the difference between the group was not significant (p = 0.083). The Profile of Mood States (POMS) questionnaire showed increased vigor with Lp299v vs. iron alone after 12 weeks (3.5 vs. 0.1, p = 0.015). No conclusive effects on physical performance were observed. In conclusion, Lp299v, together with 20 mg of iron, could result in a more substantial and rapid improvement in iron status and improved vigor compared to 20 mg of iron alone. A larger clinical trial is needed to further explore these findings as well as the impact of Lp299v on physical performance.

Effectiveness of iron supplementation for children with iron deficiency anemia: Study in Purbalingga, Central Java

Background: Iron Deficiency Anaemia (IDA) is one of major factors for human health, especially young children. Iron supplementation can indicate a good response in haemoglobin concentration. Objective: This study is to observe prevalence of anaemia and effectiveness of iron supplementation for children in Purbalingga district, Central Java. Methods: This study was a quasi-experimental study by measuring haemoglobin concentration before (pre) and after (post) treatment. Its participants were determined by a purposive sampling method. 64 children (less than 5 years old) were included in criteria of anaemia. Their blood samples were collected before the treatment to measure SI (Serum Iron) and TIBC (Total Iron Binding Capacity). Administering 4 mg of iron per kg of body weight per day was conducted for a month. Data of participants such as age, nutritional status, socio-demographic, and medical history were also collected. A paired t-test was used to analyse mean differences of haemoglobin levels before and after treatment. Results: Among the 64 children with anaemia, 98.4% indicated Iron Deficiency (ID) with 59.4% of them indicating IDA based on level of SI and TIBC. Anaemia has more prevalence in group of 6 - <12 months of age. There was a statistically significant increase of haemoglobin level with a mean difference of 1.52 g/dL between the pre and post treatment (p=0.000). Conclusion: The prevalence of IDA in children (less than 5 years old) in Purbalingga District Hospital was 59.4%. Adequately oral iron supplementation for a month indicated a statistically significant increase of haemoglobin levels

High uptake and inward diffusion of iron fortificant in ultrasonicated milled rice

Nutritional iron content in milled rice is generally lost as a result of milling due to removal of aleurone layer. Iron fortification in milled rice is recommended to regain the lost nutrients and address the malnutrition issues. This work investigates the uptake of iron and its diffusion into the kernel on ultrasonic-treated milled rice. Rice samples were subjected to ultrasonic waves resulting in the formation of microporous surfaces and the creation of fissures in the milled rice. Sonication followed by soaking in aqueous iron solution resulted in the uptake of 321 ± 13.43 mg of iron per kg of rice, a 28-fold increase compared to the endogenous iron content of milled rice with retention of 82.9% upon washing and cooking. Cross-section mapping (μ-XRF) of the concentration of the fortificant into the uncooked grains showed inward diffusion at different rates reaching into the kernel core. Results also show that sonication decreased the amount of water-soluble phosphorus in rice suggesting the removal of potentially anti-nutrient phytic acid. Textural analysis of ultrasonic-treated iron-fortified rice premix revealed favorable properties that can be advantageous for its consumer acceptability.

Annals for Educators - 21 April 2020.

Annals for Educators - 21 April 2020.

Preliminary Pharmaceutical Active Ingredient and Micronutrient Evaluation of the Leaf of Corchorus olitorius (Ahiahara)

Pharmaceutically active ingredients and micronutrient evaluation of the leaf of Corchorus olitorius were determined. The phytochemical screening using some standard methods indicated that alkaloids, flavonoids, saponins, terpenoids, phenols and tannins were present. The quantitative analysis showed the value of flavonoid as (6.25±0.5)%, Alkaloid (6.3±0.3)%, Saponin (8.01±0.6)%, Phenol (1.16±0.01)% and Tannin (1.03±0.2)%. The HI8300 multiparameter photometer result of the mineral element analysis showed that the leaf has nine out of the ten minerals analyzed for in various concentrations, the result showed that one kg of the leaf contain 0.072 mg of chromium, 15 mg of iron, 4 mg of manganese, 2.4 mg of iodine, 16 mg of phosphorus, 0.1 mg of calcium, 0.88 mg of zinc, 160 mg and 150 mg of magnesium and potassium respectively, while copper was absent. The leaf extract was subjected to different chromatographic techniques which include thin layer and column chromatograph for separation and purification, Antimicrobial screening using disc diffusion method revealed that the column eluates were active against some tested microorganism with the following zone of inhibition, Pseudomonas aeruginosa (7- 15 mm), Eschericia coli, (3-18 mm), Shigella species (12-17 mm) Staphylococcus aureus (1-8 mm), Aspergillus nomius (2-4 mm) and Aspergillus flavus (4 mm). The result portrayed that the eluates were highly bactericidal and fungicidal and of broad spectrum activities. The antimicrobial activities were compared with known standard antibiotic like ciprofloxacin and ketoconazole and was discovered that the eluates were potent and effective in both fungi and bacteria close to the antibiotics. The results scientifically validate the efficacy of the plant as acclaimed ethonomedically.

Pengaruh Konsumsi Buah Kurma Terhadap Peningkatan Kadar Hemoglobin Pada Ibu Hamil Trimester III

Background: Anemia in pregnant women is a condition of the mother with hemoglobin levels in her blood&#x0D; &lt;11.0% gr. Prevention of anemia in pregnant women can be through various ways including the fulfillment of nutrients in the body obtained from fruits and vegetables, one of them by consumption of dates. Dates contain 1.02 mg of iron per 100 grams.&#x0D; Objective: This study aims to determine the effect of consumption of dates on the increase in hemoglobin levels in third trimester pregnant women in the Klateng Community Health Center.&#x0D; Method: This type of research is a quasy experiment with a non equivalent control group design pre-test-post test design. The sampling technique used purposive sampling, obtained a sample of 30 respondents in third trimester pregnant women in the working area of ​​the Health Center in Klateng. The data analysis technique used is the Wilcoxon Sign Rank Test.&#x0D; Results: the average level of hemoglobin in the treatment group of hemoglobin levels pre (before) the administration of dates by 10.793 gr / dL and post (after) the administration of dates occurred an increase of 11,933 gr / dL and seen an increase (difference) from the average value of pre and post of 1,140 gr / dL with a standard deviation of 0.6643. Statistical test results obtained p value &lt;0.05 (0.002 &lt;0.05) so that Ho is rejected, Ha is accepted then consumption of dates has a statistically significant effect on increasing hemoglobin levels.&#x0D; Conclusion: From the results of these studies indicate the influence of consumption of dates to increase hemoglobin levels in third trimester pregnant women in the work area of ​​the Central Health Center.&#x0D;

Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters.

A normal pregnancy consumes 500–800 mg of iron from the mother. Premenopausal women have a high incidence of marginal iron stores or iron deficiency (ID), with or without anemia, particularly in the less developed world. Although pregnancy is associated with a “physiologic” anemia largely related to maternal volume expansion; it is paradoxically associated with an increase in erythrocyte production and erythrocyte mass/kg. ID is a limiting factor for this erythrocyte mass expansion and can contribute to adverse pregnancy outcomes. This review summarizes erythrocyte and iron balance observed in pregnancy; its implications and impact on mother and child; and provides an overview of approaches to the recognition of ID in pregnancy and its management, including clinically relevant questions for further investigation.

Induced‑iron overdose modulate the immune response in Atlantic salmon increasing the susceptibility to Piscirickettsia salmonis infection

Although iron has been proved as a vital element for the development of living organisms, high levels of this element can impact the normal function of different biological processes, including immune response. Therein, this study aimed to characterize the transcriptional changes in Atlantic salmon during the exposure to iron overload, evaluating the susceptibility to bacterial infection. Atlantic salmon were injected with 1 or 5 mg of iron dextran and an iron chelator (DFOM), and subsequently challenged with the intracellular bacterium Piscirickettsia salmonis. Iron levels in plasma and the transcriptional responses of the head kidney, liver, and spleen during the infection processes were evaluated. Here, iron transport, response to oxidative stress, and immune related genes were strongly modulated in individuals exposed to the metal. Fish overloaded with iron showed significant downregulation of CD83, IL-17, IL-1, Toll-like receptors, immunoglobulin, and T-cell receptors genes, suggesting an overall deleterious effect on the immune system. Furthermore, histopathological analysis evidenced that iron overdoses can strongly increase the clinical signs during the P. salmonis infection. Notably, fish exposed to 1 mg of iron and infected with P. salmonis evidenced high mortality and bacterial burden. Also, this group showed significant downregulation of immune-related genes comparing with fish with 5 mg of iron. In addition, Atlantic salmon injected with deferoxamine mesylate salt (DFOM) showed high tolerance to P. salmonis infection and an increase of IL-1b expression, suggesting a cytokines response activation. These results suggest that iron overload disrupts fish immune response although not in a doses dependent manner, and when a chelator is injected, fish present higher resistance to P. salmonis. This study reveals novel insights about teleost's immune system modulation by iron availability.

The formulation of alternative gluten-free mung bean biscuits

Biscuit is a popular snack which is consumed by people of various age. Biscuit is practical and has long storability span. The formula of mung bean biscuit contains 60% of mung bean, 20% of wheat flour, and 20% cornstarch with the roasting period of 17 minutes. The biscuit has 454 kcal, 7.95% protein, and 19.75 mg of iron. In this research, we propose to change 20% of wheat flour with gluten-free rice flour. This research aims to 1) unveil the influence of formula (rice flour, cornstarch, and eggwhite) towards the sensory quality of biscuit, and 2) to show the composition of energy and protein. This research optimizes biscuit quality by changing wheat flour with rice flour and lessen the use of cornstarch and eggwhite as the binding agent with the random group plan. The ratio between rice flour and cornstarch is in the range of 15% - 22.5% from the overall flour, with the gap of 2.5%, while the eggwhite is 21g (7%) and 30g (10%). This ratio is given to 8 different formulas. We validate the quality of the biscuit by scoring it to 8 trained panellists in a 9-scaled scoring. The method of measuring energy content in the biscuit used calorimetry, while the protein used micro Kjeldahl. This research analyzes of the influence from formula to the sensory quality with variance analysis, followed by the Duncan test. The result of the sensory test of 7 formula shows the score in the range of 6.9-7.2 or the good category. However, the scoring to the other one is in the range of 5.7–6.7 in the good and moderately good category. The sensory quality of the biscuit is in yellow, with an average of 4.0 while the texture is in the very good category with an average score of 7.5. The formula does not have a difference in all sensory quality aspects, except the yellow gold colour (p = 0.000), with a difference in between formula 1 and formula 3 along with formula 4. The best formula from all formulas is formula 5 (TB 20, TM 20, PT10). The content of energy in the biscuit is in the range of 390 – 420 kcal, while the protein is between 9.0 – 10.7 g. From the test and measurement, the gluten-free biscuit in this proposal is a proper healthy food which follows the regulation of Indonesian National Standard.

Dietary vitamin D supplementation improves haematological status following consumption of an iron-fortified cereal: an 8-week randomised controlled trial

AbstractVitamin D, a secosteroid, has recently been implicated in the stimulation of erythroid precursors and ultimately the rate of erythropoiesis. However, there are a paucity of randomised controlled trials (RCT), investigating the effect of vitamin D supplementation iron status, especially in populations at risk of iron deficiency. An eight-week, double-blind RCT was carried out in 50 female (mean age (± SD): 27 ± 9 years), iron-deficient (plasma ferritin concentration &lt; 20 μg/L) participants, randomised to consume an iron-fortified cereal containing 9 mg of iron, with either a vitamin D supplement (1,500 international units (IU)/day, 38 μg/day) or placebo. The effect of dietary vitamin D supplementation on haematological indicators was investigated. Blood samples were collected at baseline, 4-weeks and 8-week timepoints for measurement of iron and vitamin D status biomarkers. The effect of intervention was analysed with a mixed-model repeated measures ANOVA using IBM SPSS statistical software (Version 21, IBM Corporation, New York, USA). Significant increases were observed in two haematological parameters: haemoglobin concentration and haematocrit level from baseline to post-intervention in the vitamin D group, but not in the placebo group. The increase from baseline to post-intervention in haemoglobin concentration in the vitamin D group (135 ± 11 to 138 ± 10 g/L) was significantly higher than in the placebo group (131 ± 15 to 128 ± 13 g/L) (P ≤ 0.05). The increase in haematocrit level from baseline to post-intervention was also significantly higher in the vitamin D group (42.0 ± 3.0 to 43.8 49 ± 3.4%) compared to the placebo group (41.2 ± 4.3 to 40.7 ± 3.6%) (P ≤ 0.05). Despite non-significant changes in plasma ferritin concentration, this study demonstrates that dietary supplementation with 1,500IU vitamin D, consumed daily with an iron-fortified cereal led to improvement in haemoglobin concentration and haematocrit levels in women with low iron stores. Further long-term studies are required, however, these findings suggest a potential role for improvement of vitamin D status as an adjunct therapy for recovery of iron status in iron-deficient populations.

Профилактика и лечение железодефицитной анемии в практике акушера-гинеколога

The prevalence of iron-deficiency anemia (IDA) is steadily increasing. IDA is more common in women of reproductive age, pregnant women, and adolescent girls thus accounting for the importance of this issue in obstetrics and gynecology. Abnormal uterine bleeding (AUB) is one of the most common causes of IDA both in the puberty and reproductive period which requires hemostasis as well as addressing iron deficiency. A high rate of IDA was also reported in women with pelvic inflammatory diseases; this should considered when managing this large group of gynecological patients. The treatment for anemia or latent iron deficiency is performed for a long time, therefore, the selection of a medication is particularly important. Peroral Tardyferon® containing 80 mg of iron meets all modern-day requirements for anti-anemic drugs and is recommended for anemia resulting from AUB both in women of reproductive age and adolescent girls. Case studies illustrate high efficacy and good tolerability of this medication. KEYWORDS: iron-deficiency anemia, pregnancy, abnormal uterine bleeding in puberty, heavy menstrual bleeding, genital inflammation, high efficacy, compliance. FOR CITATION: Selikhova М.S., Soltys P.A., Kalacheva L.S. Prevention and treatment for iron-deficiency anemia in obstetrical gynecological practice. Russian Journal of Woman and Child Health. 2020;3(4):276–281. DOI: 10.32364/2618-8430-2020-3-4-276-281.

Microbiological aspects of the effect of Fe NPs on Wistar rats

An important route of metal intake from NP preparations is the pathway through absorption by bacterial cells of the gastrointestinal tract. This changes the composition of the microflora. Thus, giving animals NP Cu is accompanied by an increase in the total number of bacteria and lactobacilli, and a decrease in the population of E. coli and Clostridium spp. When it enters the intestine, part of the NP is able to form a pool on the inner wall of the intestine, in connection with which it can act with microorganisms inhabiting the gastrointestinal tract. The intestinal microbiota is known to play a vital role in the nutritional and immunological functions of host animals. However, in the literature there is not enough data on the influence of NP on the intestinal microbiocenosis of various representatives of the animal world and humans. The aim of the study is to study the effect of Fe nanoparticles introduced by per os on representatives of the main physiological groups of microorganisms. 30 male Wistar rats aged 4 months, identical in weight (from 180 g), were selected on the basis of analogues. up to 250 g.), physiological state, were in the previous period of experience in a balanced diet on the recommendations. Preparations of NP Fe for the introduction of per os were prepared in isotonic saline solution, treated for 30 minutes on an ultrasonic dispersant. Nanoparticles in the required amount were mixed with rice. The frequency of giving NP Fe to animals in order to correct microbiocenosis with deficient diets is 1 time in 7 days. In this case, the introduction of 10 mg of iron per kg of animal weight showed the best results.

PENGARUH PEMBERIAN BUBUR KACANG HIJAU TERHADAP PENINGKATAN KADAR HEMOGLOBIN IBU HAMIL DI DESA PSR IV NAMU TERASI KECAMATAN SEI BINGAI KABUPATEN LANGKAT TAHUN 2019

Introduction: Anemia prevalence Indonesia in 2018 reaches 48.9% (Baritbankes, 2018). 100 grams of green beans is contained 6.7 mg of iron serves to increase Hb levels and 6.9 mg of vitamin C serves to help iron absorption. Consuming 200 gr of green beans per day can meet almost 50% of the iron needs of pregnant women (Tuhana Taufiq, 2004). This study aims to determine the effect of green bean porridge on increasing Hb levels of pregnant women in Pasar IV the Village of Namu Terasi, Sei Bingai Subdistrict, Langkat Regency 2019.&#x0D; Methods: This study was a Pre-experiment study designed with the design of one group pretest-posttest and where 11 pregnant mothers of Trimester II were used as research samples taken through purposive sampling technique.&#x0D; Results and Discussion: Through the Paired Simples test the T-test obtained the value of ρ (0.01) &lt;α (0.05), which means that green bean porridge proved to significantly increase the Hb levels of pregnant women. The mean of Hb level of pregnant women before given green bean porridge was 10.9 gr / dl to 1.26, and the mean became 11.9 gr / dl to 0.93 after being given green bean porridge, it is found an increase in mean Hb levels before and after the treatment 1.01 gr / dl to 1.02 gr / dl. &#x0D; .Conclusion: Green bean porridge has the effect of increasing Hb level in pregnant women. Health workers are expected to encourage every pregnant woman to consume green bean porridge as an supplementary food.