Volatile organic compounds (VOCs) and radon progeny pose potential health risks to occupants of certain buildings via subsurface vapor intrusion (VI) to indoor air. VI mitigation is usually performed using systems that extract gas from below the building, and the system performance is typically evaluated by measuring the distribution of applied vacuum below the floor. This article provides a new approach to assessing the radius of influence (ROI) for subslab venting systems based on mass flux instead of static vacuum distribution and includes an analyses of 121 pneumatic tests performed at 65 different suction points in 16 different buildings. The mathematical model represents a two-layer system with horizontal radial flow through transmissive material below the floor slab and vertical flow through discontinuities in the floor slab (which is simplified to approximate an equivalent porous medium). The analysis includes comparisons of the flux-based ROI to values calculated using the two-layer model for 1) vacuum, 2) velocity, and 3) travel time, which may be useful as alternative performance metrics for mitigation systems.