Methylthiouracil Research Articles

LONG–TERM THERAPY IN THYREOTOXICOSIS WITH METHYL THIOURACIL

Medical Journal of AustraliaVolume 2, Issue 24 p. 677-690 Original Article LONG–TERM THERAPY IN THYREOTOXICOSIS WITH METHYL THIOURACIL Hugh R. G. Poate, Hugh R. G. Poate SydneySearch for more papers by this author Hugh R. G. Poate, Hugh R. G. Poate SydneySearch for more papers by this author First published: 01 December 1948 https://doi.org/10.5694/j.1326-5377.1948.tb74405.xCitations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume2, Issue24December 1948Pages 677-690 RelatedInformation

CRETINISM ASSOCIATED WITH METHYL THIOURACIL THERAPY

Medical Journal of AustraliaVolume 2, Issue 20 p. 588-588 Correspondence CRETINISM ASSOCIATED WITH METHYL THIOURACIL THERAPY First published: 01 November 1948 https://doi.org/10.5694/j.1326-5377.1948.tb28165.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume2, Issue20November 1948Pages 588-588 RelatedInformation

CRETINISM ASSOCIATED WITH METHYL THIOURACIL THERAPY

Medical Journal of AustraliaVolume 2, Issue 18 p. 524-525 Report of Case CRETINISM ASSOCIATED WITH METHYL THIOURACIL THERAPY G. M. Hone, G. M. Hone AdelaideSearch for more papers by this authorIvan Magarey, Ivan Magarey AdelaideSearch for more papers by this author G. M. Hone, G. M. Hone AdelaideSearch for more papers by this authorIvan Magarey, Ivan Magarey AdelaideSearch for more papers by this author First published: 01 October 1948 https://doi.org/10.5694/j.1326-5377.1948.tb28092.xCitations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume2, Issue18October 1948Pages 524-525 RelatedInformation

Treatment of Thyrotoxic Heart by Methyl Thiouracil

Treatment of Thyrotoxic Heart by Methyl Thiouracil

Relative Activities of l- and dl-Thyroxine

We have compared the biological activities of l- and dl-thyroxine in rats receiving 4-methyl-2-thiouracil by determining the ‘thyroxine requirement’ as defined by Griesbach and Purves1. This method consists of finding the amount of thyroxine which will prevent the pituitary basophil changes, resulting from the thyroxine deficiency produced by the blockage of thyroxine synthesis by the methyl thiouracil. The thyroxine samples used were: (1) l-thyroxine presented by Dr. C. R. Harington, and prepared by the iodination of l-di-iodothyronine2; (2) l-thyroxine presented by Dr. E. P. Reineke, and prepared by, acid hydrolysis of iodinated casein3; (3) l-thyroxine prepared in this laboratory from l-di-iodotyrosine by the method of Harington and Pitt Rivers4; (4) dl-thyroxine presented by Burroughs Wellcome and Co., and prepared by alkaline hydrolysis of thyroid substance.

CONTROL OF THYREOTOXICOSIS BY METHYL THIOURACIL

Medical Journal of AustraliaVolume 2, Issue 4 p. 93-106 Original Article CONTROL OF THYREOTOXICOSIS BY METHYL THIOURACIL† Hugh R. G. Poate, Hugh R. G. Poate SydneySearch for more papers by this author Hugh R. G. Poate, Hugh R. G. Poate SydneySearch for more papers by this author First published: 01 July 1947 https://doi.org/10.5694/j.1326-5377.1947.tb27572.xCitations: 6 †Read at the State meeting of the Royal Australasian College of Surgeons, Perth, Western Australia, on April 21, 1947. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume2, Issue4July 1947Pages 93-106 RelatedInformation

Antithyroid Activity of Thiouracil Derivatives

A RECENT report by Anderson et al.1 on the antithyroid activity of a series of alkyl derivatives of thiouracil shows that peak activity is reached at the n-propyl compound. A similar series of compounds is under investigation in this Laboratory, and some preliminary results may be of interest as confirming those of Anderson et al. in regard to the high activity of the n-propyl derivative. The substances under examination comprise methyl, ethyl, n-propyl, isopropyl and n-amyl thiouracil, and preliminary screening experiments indicated that the n-propyl compound was probably the most active of the series. Our experiments are not yet sufficiently complete to allot comparative values to the whole series, but they confirm the preliminary findings of the high activity of the n-propyl compound.