As a novel degradation method, laser cavitation degradation suffers from low degradation efficiency in the absence of medium gain. An enhancement method of laser cavitation using Au nanoparticles (AuNPs) is proposed for degrading organic dye wastewater. Methylene blue (MB) aqueous solution was employed as the simulated organic dye wastewater. The strong absorption characteristics of AuNPs and the mechanism underlying AuNPs-enhanced laser cavitation degradation were analyzed. The local field enhancement effect and shock wave signal were obtained. Therelationshipsamong the AuNPs, laser energy, the number of irradiations number and the degradation effect were investigated. The results show that the local field enhancement coefficient of AuNPs in Methylene blue (MB) aqueous solution reached 1.9, and the degradation degree increased by three times compared with that of pure solution because that thermal decomposition and oxidation of hydroxyl (OH) radicals were enhanced by AuNPs. With the laser energy levels increasing (70–110 mJ), the intensity of shock wave increased by 2–4 times and the degree of degradation increased by three times. The degradation rate reached 37.7 % within 3 min and the irradiation number reached 1600. Compared with other methods, the AuNPs-enhanced laser cavitation approach has exhibited remarkable controllability together with a higher degradation efficiency.