Methoxy Functionalities Research Articles

The electron‐impact induced loss of water from meconine and related derivatives

AbstractThe mass spectrum of meconine (I), a constituent of raw opium, exhibits several anomalous features (e.g. pronounced loss of H2O from the molecular ion) which are not readily explicable in terms of simple fragmentation processes. The study of the low resolution mass spectrum of meconine and its derivatives in conjunction with deuterium labeling experiments has indicated a highly specific fragmentation mechanism in which both hydrogen atoms eliminated as H2O originate from the methoxy function ortho to the lactone carbonyl group in meconine.

Electron impact promoted fragmentation of some phenothiazine derivatives

The mass spectra of phenothiazines variously substituted with chloro, hydroxy, methoxy and acetoxy functions have been measured. Mass spectrometry is able to differentiate readily between oxygenation at C-3 versus C-6, C-7 and C-8 in 2-chloro-10-(3′-dimethylaminopropyl)phenothiazine (chlorpromazine) and 2-chlorophenothiazine, although (with the exception of OMe substitution in the latter series) it will not unambiguously distinguish between isomers oxygenated at C-6, C-7 or C-8. Possible mechanistic rationalizations are presented for the origin of the principal ions in the mass spectra of the compounds investigated.