Fatigue is one of the most frequent side effects of cancer treatments. According to a number of studies, the incidence of fatigue as a side effect of radiation therapy (RT) ranges from 65% to 100% depending on which instruments were used (Greenberg et al., 1992; Jacobsen-Thors, 2003). For many cancer patients, cancer-related fatigue is severe and imposes limitations on normal daily activities (JereczekFossa et al., 2002). Patients often report that cancerrelated fatigue differs from fatigue experienced before initiation of cancer. They describe it as severe, chronic and frustrating, effects that fail to be relieved by rest. In many studies in the past, patients have felt that fatigue has adversely affected their quality of life more than pain and sexual dysfunction or other treatment-related side effects (Stone et al., 1998). Fatigue has negative impact on various aspects of quality of life, so it is imperative to find non-invasive and nonpharmacological solutions for managing it. There is little however known as to which techniques can help alleviate fatigue. Physical exercise has been shown to be effective, convenient and a low-cost self-care method for reducing anxiety and sleep difficulties, and increasing adaptation during radiotherapy. Aerobic exercises (e.g. walking) have been suggested for the rehabilitation of cancer patients affected by energy loss but this is not a fully accepted approach as yet. Nevertheless, exercise has been shown to