Element Method Analysis Research Articles

Effects of pyrolysis temperatures on the structural properties of straw biochar and its adsorption of tris-(1-chloro-2-propyl) phosphate

To investigate the effect of pyrolysis temperature on the adsorption behavior of the emerging organic pollutant tris-(1-chloro-2-propyl) phosphate (TCIPP) on biochar, corn stover was used as raw materials to prepare biochars at different pyrolysis temperatures (250, 350, 500, 700 °C) through limited oxygen carbonization. Elemental analysis, Boehm titration, FTIR, XPS, and other analytical methods were used to reveal the effect of pyrolysis temperature on the physicochemical properties of biochar and its mechanism of TCIPP adsorption. The results showed that the pyrolysis temperature had a significant impact on the physicochemical properties of biochar. As the pyrolysis temperature increases, the specific surface area of biochar rises from 3.083 m2/g to 435.573 m2/g, the pH value increases from 6.60 to 10.66, the mass percentage of C increases from 63.10 to 80.58%, and the mass percentage of O decreases from 26.42 to 9.20%. Additionally, the hydrophobicity and aromaticity of biochar also increase with rising pyrolysis temperature, while its polarity decreases. Boehm titration, FTIR, and XPS analysis showed that the total amount of functional groups on the surface of biochar decreased relatively with increasing temperature. Functional groups such as -OH, C = C/C = O, and C-O-C participated in the adsorption of TCIPP on biochar, and ester groups were produced after adsorption. The adsorption process of TCIPP on biochar fits best with the pseudo-second-order equation, indicating that the adsorption process is mainly chemical adsorption, and the main rate-controlling stage is intraparticle diffusion. The isothermal adsorption results were more in line with the Temkin model, indicating that the adsorption process of TCIPP on biochar was mainly surface adsorption. As the pyrolysis temperature increases, the maximum adsorption capacity of biochar increases from 0.8837 mg/g to 2.2574 mg/g. The adsorption process of TCIPP on biochar mainly included pore filling, hydrogen bonding, P-π interaction, hydrophobic interaction, and electrostatic attraction. Among them, pore filling, P-π interaction, and hydrophobic interaction were significantly enhanced with increasing temperature, while hydrogen bonding was relatively weakened. This study will provide a theoretical basis and technical support for the removal of TCIPP from water using biochar adsorption.

Applicability evaluation technology for steel small diameter pipes containing external surface corrosion defects

With the continuous operation of oil and gas stations and petrochemical equipment, it has been found that steel small bore pipelines have different degrees of corrosion defects, which have led to pipeline cracking and medium leakage, and have increasingly attracted great attention of their oil and gas and chemical enterprises. In order to ensure the safe operation of the small diameter pipes with external surface corrosion defects, the influence law of the size of corrosion defects on the bearing capacity of the small diameter pipes were studied by finite element analysis and test simulation method, and the damage mechanism and failure form were analyzed, and the failure pressure prediction formula of the small diameter pipes with defects was fitted. It provides technical guidance for the applicability evaluation of corrosion-containing steel small diameter pipes in oil and gas chemical stations or installations.

Energy Dispersive X-Ray Fluorescence Spectrometry Using a Matrix Corrected Fundamental Parameters Algorithm vs. Acid Digestion with ICP-AES: A Comparison of Two Methods for Soil Elemental Analysis

ABSTRACT Energy dispersive X-ray fluorescence spectrometry (ED-XRF) is evaluated as an alternative to conventional acid-mediated soil digestion methods for analysis of aluminum (Al), calcium (Ca), iron (Fe), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), phosphorus (P), silicon (Si), strontium (Sr), titanium (Ti), and zirconium (Zr). The Kellogg Soil Survey Laboratory (KSSL) currently uses microwave-assisted digestion with inductively coupled plasma – atomic emission spectrometry (ICP-AES) to measure the 12 elements (Al, Ca, Fe, K, Mg, Mn, Na, P, Si, Sr, Ti, Zr). The equipment needed to conduct the digestion method is expensive, the materials are hazardous, and the method is laborious. The Kellogg Soil Survey Laboratory (KSSL) has observed variable elemental recoveries for certain elements. The objective of the study was to evaluate an ED-XRF method as an alternative to the KSSL digestion method. The literature offers few examples of X-ray fluorescence (XRF) method development and validation. The candidate ED-XRF method offered a more efficient, less expensive, and less hazardous approach for measuring the 12 elements. Relative to the digestion method, the candidate ED-XRF method showed improved precision and accuracy for specific elements.

An improved approach to compensating for cure‐induced deformation to manufacture composite aircraft skin accurately

AbstractThe purpose of this paper is to compensate for the cure‐induced deformation to manufacture composite aircraft skin with variable curvature accurately. Firstly, a finite element analysis (FEA) method appropriate for curing simulation was described. Then, the discrete curvature‐based displacement adjustment (DC‐DA) method for mold surface compensation was proposed. The DC‐DA method utilizes the discrete curvature of the section points to obtain a smooth compensated curve. Finally, a skin part was selected to prove its effectiveness. The experimental results showed that after the mold's surface was modified by the DC‐DA method with the FEA‐predicting deformation as input, the forming shape could meet the requirement of the part accuracy in one cycle. The DC‐DA method was also compared with the displacement adjustment (DA) method and proved to be more efficient for the compensation of composite skin with variable curvature.Highlights The FEA is appropriate for the calculation of the skin's curing deformation. The DC‐DA method is efficient for compensating for the skin's deformation. The shape of the case part could meet the requirement of accuracy in one cycle.

Fatigue Analysis on a Newly Designed Hip Implant with Finite Element Method

This study used Finite Element Analysis (FEA) and Reverse Engineering (RE) methods to assess the fatigue performance of an originally designed cementless hip implant. The implant prototype was initially scanned using 3D scanning technology, and a finite element model was created. The implant was analyzed under dynamic loads for six different biomaterials commonly used, namely Ti-6Al-4V (Grade5), ASTM F3046 (Ti-3Al-2.5V), ASTM F75 (CoCr), ASTM F562(MP35N), ASTM F136(Ti6Al4V ELI), ASTM F67 (Ti Grade 4), and the fatigue life was evaluated. The results showed that the ASTM F75 (CoCr) implant had the highest stress and the ASTM F67 (Ti Grade 4) implant had the lowest stress. Also, Ti6Al4V (Grade 5) implant is more resistant to fatigue than their counterparts made from ASTM F75 (CoCr), ASTM F136 (Ti6Al4V ELI) and ASTM 3046 (Ti-3Al-2.5V).

The Impact of Stress Distribution on The Electrical Performance of Different Silver Stretchable Conductive Ink Pattern Using FEA Simulation

Stretchable conductive ink has been widely investigated to be used in the fabrication of stretchable electrical devices. Experimentation methods to test the mechanical and electrical behaviours of the stretchable conductive ink composite are commonly applied; however, not much of the computational approach has been scrutinized to validate the results further. This paper employs the finite element analysis method to investigate the relationship between the stress and strain distribution of the stretchable conductive ink with the highest strain obtained. This research validates the past experimentation works of different patterns of stretchable conductive ink for its stretchability and electrical performance. The maximum Von Mises stress (VMS) and maximum principal strain of the stretchable conductive ink played a significant role in determining its electrical performance, rather than the localisation of high stress and strain at specific locations within the stretchable conductive ink pattern. Zigzag pattern exhibited the lowest maximum stress and strain concentration at 57.826 MPa and 4.05% while straight pattern suffered the highest respective values at 118.143 MPa and 10.39%. The lower maximum Von-Mises stress and principal strain contributed to a better stretchability which is indicated by a higher strain rate prior to electrical conductivity.

Three-dimensional finite element analysis of stress distribution on different complex macro designs in commercially available implants: An in-vitro study

ObjectiveThis study aimed to investigate the effects of different commercially available complex implant macro designs on stress distributions using Finite element analysis. The experiment is done under varying simulated bone conditions to provide reference for clinical application. Materials and methodsThe study employed the Finite Element Analysis (FEA) method to compare four commercially available complex implant macro designs on a Computer-Aided Design (CAD) model of a maxillary bone segment. The three-dimensional geometrical model of the implants was reconstructed from computed tomography (CT)-slices in Digital Imaging and Communications in Medicine (DICOM) format and contact condition between the implant and the bone was considered as ‘Bonded’, implying perfect osseointegration. All materials used in the models were assumed to be isotropic, homogeneous, and linearly elastic. The Finite element simulations employed load of 400 N under both axial and non-axial conditions Stresses were analysed under different bone conditions. ResultsAverage values of von Mises stresses were used for comparing stress levels between implant designs. There was a definite increase in the equivalent stress values from higher density(D1)to lower density (D4) bone conditions for all implants. The percentage of increase ranged from 23.63 to 49.39 on axial loading and 20.39 to 57.19 when subjected to non-axial loading. The equivalent stress values resulted from non-axial loading were 1.78–2.94 times higher than that of axial loading for all implants under all bone densities. Among the complex designs Equinox Myriad Plus implant exhibited the least stress under axial loading (12.749–19.046 MPa) and (37.462–49.217 MPa) for non-axial loading. The stress on the crestal module was higher (1.49–2.99 times) than the overall stress on the implant regardless of the loading direction or bone conditions. ConclusionsData from the present study shows Equinox Myriad Plus implant generating the least equivalent stress and this can be taken as indicator in the biomechanical performance of the design.

Modal analysis and seismic optimization of multi-storey gymnasium frame

In order to improve the seismic resistance capacity of the multi-storey gymnasium frame, based on the finite element analysis method, the dynamic response characteristics were analyzed, and the natural frequencies and vibration modes were obtained. Based on the results of the modal analysis, different reinforcement methods were proposed for verification. Under the excitation conditions of Borego waves, the vibration responses of different nodes in initial model were obtained. Modal verification was carried out by using two methods of shear strengthening and support rod strengthening respectively. The analysis results show that the bearing capacity of the single-span frame is insufficient, the lateral stiffness is small, and it is prone to cause severe torsional vibration damage. It can also be known that the seismic resistance capacity of the support rods reinforcement is more balanced in different directions. It can not only effectively improve the lateral stiffness and bearing capacity of the structure, but also improve the seismic performance of the main structure through the energy dissipation of component yield, which is more suitable for multi-story buildings.

Finite element analysis of rockfall impact on pipelines with different erosion resistant coatings

In this paper, the finite element analysis method is used to extensively study the response of rockfall impact on pipelines with different erosion resistant coating. Based on the numerical results, the safety of the pipeline is comprehensively evaluated. Firstly, through the establishment of detailed pipeline and rockfall models, the impact of different rockfall materials and speeds on the pipeline is simulated. The results of the finite element analysis indicate that rockfall impact can cause significant stress concentration and deformation in the pipelines and damage to the coating. With the increment of impact speed, the damage to the pipeline also increases significantly, and different rockfall materials exhibit varying damage conditions, and it is found that fibreglass reinforced epoxy is better than the polyethylene coating. By comparing the analysis results under different conditions, the safety threshold of the pipeline under various rockfall impact scenarios is obtained. This provides an important theoretical basis and reference for the protection design and safety maintenance of the pipeline. The research in this paper not only aids in deepening the understanding of the mechanism of rockfall impact on pipelines but also serves as a valuable reference for improving the safety and reliability of pipeline engineering.

A Gaussian statistics-based unit-cell modeling method for the mechanical behavior prediction of 2.5D shallow straight-link-shaped woven composites

The shallow straight-link-shaped structure of 2.5D woven composites (2.5D-SSLS-WC) is a novel material with a wide range of promising applications, but the randomness of its internal structure has brought challenges to performance prediction and engineering design. The gap of existing unit-cell models in capturing the internal randomness of the 2.5D-SSLS-WC material limits the accurate prediction of properties and the optimization of engineering design. In this work, the modeling method for random unit-cell model based on Gaussian distribution is proposed for 2.5D-SSLS-WC structure considering random distribution property of weft yarns and extrusion effects between structural surfaces and internal yarns during the molding process, which can more effectively reflect the practical mesoscopic structure of the material, reveal the micro mechanical behavior inside materials and provide theoretical basis for material design and performance optimization. The mechanical property and damage evolution of the proposed model is predicted and analyzed using finite element (FE) analysis and progressive damage method. The maximum errors of equivalent stiffness and strength between prediction and experimental values are 6.7% and 2.3%, respectively. The results show that the proposed model has high prediction accuracy and can reasonably reflect the damage extension and ultimate failure mode of the material during the loading process, which verifies the rationality of the proposed unit-cell modeling strategy. The modeling method proposed in this paper provides a new perspective for the in-depth understanding and description of the microstructure and mechanical behavior of 2.5D-SSLS-WC materials, which is of significant theoretical and engineering value and can be extended to the modeling of other woven composites.

Benzimidazolium salts bearing ester group: Synthesis, characterization, crystal structure, molecular docking studies, and inhibitory properties against metabolic enzymes

In this work, the synthesis of several unsymmetrical benzimidazolium salts with an ester (2-ethoxy-2-oxoethyl) group on the nitrogen atom is described. The structures of all compounds were fully characterized by spectroscopic (1H, 13C NMR, FTIR) and analytical (elemental analysis) methods. However, single-crystal X-ray diffraction analysis elucidated the molecular and crystal structures of compounds 1a and 1c. Asymmetric units of both crystal structures contain two crystallographically independent molecules and two bromide anions. All compounds exhibited substantial inhibition against the cytosolic carbonic anhydrase isoforms (hCA I and hCA II) and acetylcholinesterase (AChE) with Ki values 51.00–45.18 nM, 46.94–305.65 nM, and 17.57–65.68 nM, respectively. Notably, compound 1d showed extreme inhibitory effect against hCA I with 51.00±5.31 nM (AZA: 275.44±13.32 nM), hCA II with 46.94±5.44 nM (AZA: 236.55±17.88 nM) and AChE with 17.57±3.14 nM (TAC: 80.44±6.88 nM). In silico approach showed that compound 1d could form stable complexes with target enzymes with a different binding affinity (BE:9.01 kcal/mol for AChE; -7.22 kcal/mol for hCA II and -6.51 kcal/mol for hCA I). The results supported the medical potential of benzimidazolium salts containing ester group. They significantly lighted our knowledge about the chemistry of side groups on phenyl ring especially in the para position as compared to ortho and meta positions.

Anchorage loss of the posterior teeth under different extraction patterns in maxillary and mandibular arches using clear aligner: a finite element study

BackgroundExtracting the premolars is an effective strategy for patients with bimaxillary dentoalveolar protrusion. Clear aligners (CAs) close the extraction spaces through shortening the length of aligners. The contraction force generated by the terminal of aligners makes the posterior teeth tip mesially, which is known as the roller coaster effect. This phenomenon is even worse in the 2nd premolar extraction cases. Posterior anchorage preparation is commonly used to protect the angulation of molars, taking the form of presetting distal tipping value. However, the distal tipping design aggravates the anchorage loss of anterior teeth simultaneously. This study aimed to explore the different anchorage loss of the posterior teeth when the 1st or 2nd premolars were extracted using CAs, respectively in maxillary and mandibular arches, further providing guidance for anchorage preparation design in clinical practice.MethodsTwo bimaxillary finite element models with different extraction patterns were established to simulate the anterior en-masse retraction process of the CAs. In Model 1, the maxillary and mandibular 1st premolars were extracted, while in Model 2, the 2nd premolars were extracted. Finite element analysis methods were utilized to analyze the tipping angle of the anterior and posterior teeth.ResultsCompared between two models, the anterior teeth exhibited a greater lingual inclination tendency and the posterior teeth exhibited a slighter mesial tipping tendency in Model 1 regarding individual tooth. The closer to the extraction spaces, the greater the tip, and the distal tipping tendency of the 1st premolars was more evident than the mesial tipping tendency of the 1st molars in Model 2. Compared between the maxillary and mandibular arches, the mesial tipping tendency of individual posterior tooth was more evident in the maxilla. In addition, the highest hydrostatic stress of the periodontal ligaments was concentrated on the cervical and apical parts directly adjacent to the extraction spaces, and it exhibited relatively uniform distribution in Model 1.ConclusionsThe individual posterior tooth showed the same mesial tipping direction but to different degree when the 1st or the 2nd premolars were extracted during clear aligner treatment. Presetting anchorage preparation design for the posterior teeth is essential to alleviate the roller coaster effect, especially in the 2nd premolar extraction cases. Furthermore, larger anchorage preparation value should be proposed for the maxillary posterior teeth.

Determination of an optimum patch configuration in the repair of a center crack in thin aluminum sheet using polymer composite patch

AbstractThe formation of cracks and their growth is an issue of concern in structural applications incorporating thin metal sheets. Adhering cracked region with a patch of composite material has proved effective in repairing cracks. Determining an optimum configuration of composite patch is still a challenge as a shorter patch may not be effective and a larger patch leads to wastage of resources. An appropriate methodology is required for specifying an optimum patch configuration in terms of its length, width, and thickness. The work presented prescribes a methodology for obtaining an appropriate combination of geometrical parameters of the composite patch. The computational tools like finite element analysis and response surface method have been incorporated. This is an extensive work consisting of a number of iterations of numerical analyses carried out for different combinations of the length and width of the patch. The results were also obtained for three different patch thicknesses in which the number of plies were increased from a single ply to three plies. The optimum size was obtained for each of the three patch thicknesses. Finally, a methodology for obtaining the most appropriate patch configuration based on the practical constraint of a small available area is prescribed.Highlights The crack repair in a thin structural sheet using fiber reinforced polymer composite patch separates at the interface. The optimum size of the patch needs to be used for an effective repair. The work consists of a combination of experiments and numerical simulations using finite element analysis. Response surface methodology is employed in this optimization study.

Research and Analysis of Liquid Cooling Heat Dissipation Equipment for Insulated-Gate Bipolar Transistor Modules of Wind Power Converters Based on the Finite Element Analysis Method

The primary objective of this study is to develop a simulation model for a liquid cooling plate (LCP) for insulated-gate bipolar transistor (IGBT) modules, with the aim of reducing the operating temperature of wind power converters (WPCs). The initial impetus for this study was the observation that the energy conversion efficiency of a WPC declines when the operating temperature of the IGBT module exceeds a critical threshold. Three LCPs, with and without heat sinks, were modelled under extreme conditions using the finite element simulation method. The effect of the number and height of the fins on the cooling efficacy was evaluated through the simulation and analysis of the LCP model with heat sinks. The results demonstrate that the optimal configuration, comprising five 10 mm fins and 13 10 mm struts, can achieve the following reductions: maximum temperature by 11.4 K, heat dissipation efficiency by 3.33%, pressure drop by 10.6 KPa, and pump power by 31.00%. Moreover, the findings suggest that the number of fins has a significant impact on temperature fluctuations, whereas the height of the fins exerts a markedly significant influence on pressure drop.

Synthesis and Characterization of s-Triazine Cored Schiff Base Containing β-lactam and Its [M(Salen/Saloph)] (M= Cr3+ and Fe3+) Capped Complexes

This study consists of a tripodal 6-iminopenicylanic acid ligand synthesized based on the s-triazine group and its four trinuclear complexes. For this purpose, 2,4,6-tri(p-formylphenoxy)-1,3,5-triazine (III) (TRIPOD) was obtained from the reaction of 2,4,6-trichloro-1,3,5-triazine and 4-hydroxybenzaldehyde. Then, tripodal target ligand (V) was obtained from the reaction of TRIPOD and 6-aminopenicylanic acid. Finally, tripodal trinuclear (ML) capped target complexes were obtained from the reactions of the initial complexes [(ML)2O] (M= Cr3+ or Fe3+, L= Salen or Saloph) with the target ligand in methanol media. The structures of all obtained ligands were elucidated using 1H NMR, FT-IR, and elemental analysis methods. The structures of the complexes were characterized using FT-IR, magnetic susceptibility, ICP-OES, and TGA methods.

Aircraft Structural Assessments in Data-Limited Environments: A Validated FE Method

Aircraft operators often modify aircraft configurations, install new equipment, and alter airframes to accommodate this equipment, leading to operations in flight envelopes different from original design profile. These modifications necessitate airframe structural assessments, which typically require comprehensive aircraft design data, often unavailable to operators. This study aims to develop and validate a practical method for finite element analysis (FEA) of aircraft structures in the absence of this detailed design data. Focusing on a case study involving structural analysis of an aircraft wing, this study presents assumptions and idealizations used to develop 2.5D finite element (FE) model of the wing. Fidelity of this model is established by comparing FE analysis results with experimental data. Key validation metrics include reaction forces, load distribution at wing-fuselage attachments, and deformation at reference points on the wing under design load. Comparison between FE analysis and experimental results is carried out to substantiates accuracy of these geometric simplifications and idealizations of load-carrying behaviour of structural members. Therefore, practicality of these idealizations in absence of design data is demonstrated. This study offers a novel approach for structural assessments of aircraft without relying on proprietary design data. The validated method enhances capability of aircraft operators to perform effective structural analyses, thereby extending service life of aircraft with continued airworthiness.

Determination of the Gurson-Tvergaard-Needleman damage model parameters for simulating small punch tests of heat-resistant alloys

The small punch (SP) test is utilized to assess the mechanical characteristics and damage progression of heat-resistant alloys. The inverse finite element analysis method incorporating SP tests is a parameter identification method based on adjusting the accuracy of the simulated load-displacement curves. In this paper, the elastoplastic parameters of the Hollomon model and the damage parameters of the Gurson-Tvergaard-Needleman (GTN) model are determined based on the undamaged and damaged stages of the load-displacement curves, respectively. The whole stress-strain curves of the tested materials are then built using the results of finite element simulations of the tensile specimens of ZG15Cr2Mo1, P91, 316H, and Hastelloy X at room and elevated temperatures. Comparison with uniaxial tensile tests indicates that the simulated stress-strain curves closely resemble the experimental data from the tensile testing. In addition, the simulated damage evolution characteristics of the SP specimens are consistent with the mechanical model based on the actual deformation behavior. It is possible to comprehend the damage evolution process by analyzing the SP specimens’ stress and strain change characteristics.

Simulation of metal fatigue crack analysis based on thermal environment numerical analysis in street metal sculpture design process

With the popularity of urban public art, metal materials are easily affected by environmental factors in practical applications, especially the influence of thermal environment on metal fatigue, which often leads to cracks in sculptures, affecting their service life and safety. Through the numerical analysis of thermal environment, the fatigue crack generation mechanism of street metal sculpture in the process of use is deeply discussed in order to provide theoretical support and practical guidance for sculpture design. The finite element analysis method is used to simulate the stress distribution of metal sculpture under different thermal conditions. By setting a variety of conditions such as ambient temperature and humidity, the corresponding thermodynamic model is established, and the fatigue properties of metal materials are evaluated comprehensively The numerical model is calibrated with experimental data to improve the accuracy of the simulation. It is found that the change of thermal environment significantly affects the internal stress distribution of metal sculpture, and then affects the generation of fatigue cracks. At high temperature, the fatigue limit of the material is reduced, which leads to more cracks. Under the condition of sudden temperature change, the stress concentration of the material is more obvious, and the fatigue life of the metal is significantly shortened.

THERMAL TECHNOLOGICAL CONDITION OF IVG.1M RESEARCH REACTOR CORE UNDER VARIOUS OPERATING MODES

The relevance of the study is related to the determination of the thermal characteristics of the IVG.1M research reactor core with the low enriched uranium fuel under the nominal and design operating modes. The thermal technological condition of the IVG.1M research reactor during the start-up are determined by the readings of the temperature, pressure and coolant flow sensors of the information and measuring system. The indirect methods including the computer simulating ones are used to determine the temperature of the core structural materials and the distribution of the coolant temperature by the height of the fuel assembly. The research has been carried out using the method of the finite element analysis using the ANSYS Fluent software package. The study goal was to verify the adequacy of the calculation methodology and obtain the calculated data on the temperature distribution in the fuel assembly in the reactor power range from the nominal to design one. The article presents a description of the IVG.1M reactor, the research methodology, computer model, simulation results and the comparison of the calculated data with the experimental ones. The study scientific novelty consists in determining the temperature conditions of the fuel rods during the reactor operation at various levels of the design capacity with a conservative approach to the cooling conditions. The significance of the research results lies in the fact that a computer model can be used to determine the characteristics of the IVG.1M reactor core under the reactor various operating modes and to analyze the thermohydraulic processes in the fuel assembly.

New Pyrazole/Pyrimidine-Based Scaffolds as Inhibitors of Heat Shock Protein 90 Endowed with Apoptotic Anti-Breast Cancer Activity.

Background/Objectives: Supported by a comparative study between conventional, grinding, and microwave techniques, a mild and versatile method based on the [1 + 3] cycloaddition of 2-((3-nitrophenyl)diazenyl)malononitrile to tether pyrazole and pyrimidine derivatives in good yields was used. Methods: The newly synthesized compounds were analyzed with IR, 13C NMR, 1H NMR, mass, and elemental analysis methods. The products show interesting precursors for their antiproliferative anti-breast cancer activity. Results: Pyrimidine-containing scaffold compounds 9 and 10 were the most active, achieving IC50 = 26.07 and 4.72 µM against the breast cancer MCF-7 cell line, and 10.64 and 7.64 µM against breast cancer MDA-MB231-tested cell lines, respectively. Also, compounds 9 and 10 showed a remarkable inhibitory activity against the Hsp90 protein with IC50 values of 2.44 and 7.30 µM, respectively, in comparison to the reference novobiocin (IC50 = 1.14 µM). Moreover, there were possible apoptosis and cell cycle arrest in the G1 phase for both tested compounds (supported by CD1, caspase-3,8, BAX, and Bcl-2 studies). Also, the binding interactions of compound 9 were confirmed through molecular docking, and simulation studies displayed a complete overlay into the Hsp90 protein pocket. Conclusions: Compounds 9 and 10 may have apoptotic antiproliferative action as Hsp90 inhibitors.