In this paper, a modified genetic algorithm (GA), Meta-GA, was developed to determine the optimal sensor placement (OSP). Then, the proposed OSP method was compared with the other two GA-based methods. Finally, a 15-month-long structural health monitoring was conducted for Lugou Bridge using the best sensor layout. The deformation monitoring results were compared with point cloud using a four-step method. The damage detection capability of the obtained sensor layout was also verified. The results show that Meta-GA has good computational efficiency and it can save 9.16 %∼28.24 % of optimization time compared to GA. Moreover, the damage sensitivity index obtained from Meta-GA is 12 %∼64 % higher than those of GA-based methods. Furthermore, the error between the monitoring deformation and the point cloud results is almost within 15 %. 90 % of apparent damage locations can be identified based on current sensor data. The research results can support for the structural health monitoring of masonry bridge.