In recent times, there has been a notable increase in the quantity of high-rise buildings, attributed to the swift advancements in both economic growth and construction technology. Assessing the structural integrity of high-rise buildings is important to ensure their safe operation. However, existing structural health monitoring methods typically require a baseline, involving either the measured dynamic and static responses from an intact structure or the finite element (FE) model corresponding to an undamaged state. These prerequisites are often challenging to acquire in practical scenarios. This study introduces a novel baseline-free method for detecting reduction in the lateral stiffness of high-rise buildings. The method is based on the statistical moment curvature (SMC) concept, determined through applying central difference to the second-order statistical moment of displacement. Initially, theoretical formulas were derived to demonstrate the viability of utilizing SMC for identifying reduction in the lateral stiffness of high-rise buildings. Subsequently, a FE model of a representative high-rise building was constructed to validate the proposed approach and assess its sensitivity, where different structural types and noise levels were considered. Lastly, a field test was conducted on a 33-story shear wall structure to provide additional validation for the proposed method. The results confirmed its effectiveness in accurately detecting reduction in the lateral stiffness of high-rise building. It offers two primary benefits: firstly, it obviates the need for a baseline, rendering it more convenient and applicable in real-world scenarios; secondly, its heightened sensitivity to sudden drops in lateral stiffness allows for early-stage detection of structural damage.