Methodological Considerations Research Articles

Toward a globally inclusive knowledge base on adolescent development: A charge to the Majority World and a plea for epistemic and paradigmatic pluralism.

Ongoing internal dialog on the limitations of Euro-American developmental science has opened up space to explore how best to work toward a knowledge base that is adequately representative of the values, cultures, epistemic traditions, and lived experiences of peoples, nations, and regions around the world. So far, recommendations for the advancement of a global developmental science have focused preponderantly on (1) methodological considerations and (2) an architecture to support cross-disciplinary international collaborative inquiry and/or enhance research capacity building for Majority World scholars and institutions. In this commentary, instead of focusing on specific contributions to the Special Issue, I make a case for an explicit commitment to field-building within Majority World contexts as the primary gap-closing path toward the cultivation of a global developmental science knowledge base. I begin with a worldwide population analysis to demonstrate the magnitude of geopolitical, eco-cultural, and epistemic imbalances inherent in the shaping of Euro-American developmental science. In tandem with the Special Issue's central theme, I draw on scholarship from the fields of history, sociology, and political economy to link decolonial theory to the advancement of a global developmental science. Finally, I explore ways in which exemplary research establishments already engaged in prolific inquiry and research training may be ideal candidates to support field-building and help to advance multidisciplinary inquiry within an ethos of epistemic and methodological pluralism.

The moving wave: Applications of the mobile EEG approach to study human attention.

Although historically confined to traditional research laboratories, electroencephalography (EEG) paradigms are now being applied to study a wide array of behaviors, from daily activities to specialized tasks in diverse fields such as sports science, neurorehabilitation, and education. This transition from traditional to real-world mobile research can provide new tools for understanding attentional processes as they occur naturally. Early mobile EEG research has made progress, despite the large size and wired connections. Recent developments in hardware and software have expanded the possibilities of mobile EEG, enabling a broader range of applications. Despite these advancements, limitations influencing mobile EEG remain that must be overcome to achieve adequate reliability and validity. In this review, we first assess the feasibility of mobile paradigms, including electrode selection, artifact correction techniques, and methodological considerations. This review underscores the importance of ecological, construct, and predictive validity in ensuring the trustworthiness and applicability of mobile EEG findings. Second, we explore studies on attention in naturalistic settings, focusing on replicating classic P3 component studies in mobile paradigms like stationary biking in our lab, and activities such as walking, cycling, and dual-tasking outside of the lab. We emphasize how the mobile approach complements traditional laboratory paradigms and the types of insights gained in naturalistic research settings. Third, we discuss promising applications of portable EEG in workplace safety and other areas including road safety, rehabilitation medicine, and brain-computer interfaces. In summary, this review explores the expanding possibilities of mobile EEG while recognizing the existing challenges in fully realizing its potential.

Understanding how Latinx youth cope with discrimination: A call to action.

Racial-ethnic discrimination leads to poorer academic and mental health outcomes for Latinx youth. Although there is a growing literature on the resilience processes that shield Latinx youth from the negative ramifications of these experiences, there is limited work that specifically considers the coping behaviors and processes that youth enact to counter the harmful impact of racial-ethnic discrimination. This limited work is further hampered by a lack of measurement tools that account for the uniqueness of racial-ethnic discrimination as a stressor and the culturally relevant coping strategies endemic to Latinx populations. This article reviews the mixed findings among studies that have examined discrimination, coping strategies, and Latinx youth outcomes. Furthermore, the pressing need for a new measure that would better capture the nuanced manner in which Latinx adolescents cope with racism-related stress is outlined. This work concludes with methodological considerations as well as recommendations for the field's study of coping with the insidious impact of racism-related stress among Latinx adolescents. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Methodological considerations in the study of perceived discrimination at work and its association with workers health and occupational outcomes: A scoping review.

Perceived workplace discrimination is a complex phenomenon involving unfair treatment in the workplace based on personal characteristics such as age, ethnicity, gender, or disability. The objective of this study is to explore the association of perceived workplace discrimination with health and occupational outcomes. Following the PRISMA-ScR guidelines and the Joanna Briggs Institute methodology, a scoping review of articles published between 2000 and 2022 was conducted in databases such as Pubmed, Scopus, and PsyInfo. Inclusion criteria focused on studies exploring perceived workplace discrimination among workers, excluding those on patients, students, or the general population, and articles not written in English or Spanish. Of the 9,871 articles identified, 102 met the criteria and were analyzed. Research showed a progressive increase in the study of perceived workplace discrimination, with a majority of studies in North America and Europe and a predominance of cross-sectional designs. Most studies did not clearly define the concept of perceived workplace discrimination nor report the psychometric characteristics of the measurement instruments. A significant association was found between perceived discrimination and negative outcomes in workers' mental and physical health, as well as a negative impact on job satisfaction and an increase in absenteeism. Additionally, sociodemographic characteristics such as race/ethnicity, gender, and age influenced the perception of discrimination. This review confirms that perceived workplace discrimination significantly impacts the health and job satisfaction of workers, with particular detriment in minorities and women. Despite an increase in research over the last two decades, there remains a lack of consistency in the definition and measurement of the phenomenon. Most studies have used cross-sectional designs, and there is a notable absence of research in the Latin American context.

The (complex) effect of internet voting on turnout: Theoretical and methodological considerations

AbstractThe adoption of remote internet voting can be a rather complex reform. In theory and praxis, geographical units can either decide to adopt or not to adopt i‐voting. Those that adopt it can differ in the mode of i‐voting adoption (i.e., internet‐only voting, or also in‐person voting), and the timing of adoption (i.e., some geographical units might adopt it earlier than others). How does the decision to adopt internet voting, the mode of adoption and the timing of adoption influence turnout? Using data spanning the municipal elections in Ontario, Canada from 2000 to 2018, we try to answer these research questions. Generally, we find that allowing internet voting, regardless of the availability of in‐person voting, does not influence turnout over the long term. However, we do find a temporal pattern, in that some of the most participatory municipalities adopted internet voting the earliest. We also detect a novelty effect; a sizable increase in turnout during the first ever election in which internet voting was introduced, which vanished in following elections.

EXPLORING ARTS-BASED METHODS IN UNPAID CAREGIVING CONTEXTS: A SCOPING REVIEW

Introduction:Unpaid caregiving plays a crucial role in supporting older adults, requiring innovative approaches to understand and enhance caregivers' experiences. Research Objectives: As a response, this scoping review investigates the application of arts-based methods in understanding the caregiving experience, as well as the advantages and limitations of these methods in providing care to diverse populations. Methodology: Building on Arksey and O’Malley's framework, our methodology draws from the Joanna Briggs Institute approach. Eligibility criteria encompassed peer-reviewed publications in English from 2007 to 2022, focusing on unpaid caregivers, arts-based methods, and caregiving experiences. Six comprehensive databases were queried, with the initial searches yielding 761 articles. Full text screening of 66 papers resulted in 19 papers for inclusion in the scoping review. Results: Analysis of the literature revealed the multifaceted applications of arts-based methods in understanding and supporting unpaid caregivers. These encompassed a wide range of creative techniques, such as visual arts, photo elicitation, storytelling, and performance – which provided insights into the emotional, psychological, and social dimensions of caregiving. Findings highlighted the potential for arts-based methods to enhance caregiver well-being, foster self-reflection and self-care, and promote dialogue. Nonetheless, there were notable gaps. Racial and ethnic diversity was often neglected in the studies (addressed in 3 of 19), underscoring the necessity for tailored interventions and methodological considerations for diverse populations. Importantly, dementia caregiving received substantial attention (12 of 19). Final Considerations: This scoping review highlights the growing interest in integrating arts-based methods into caregiving research and interventions amongst qualitative and mixed methods approaches. By mapping out the landscape of existing literature, this review underscores the need for further exploration and methodological refinement to harness the full potential of creative techniques in advancing our understanding of unpaid caregivers' lived experiences. Arts-based approaches hold promise in providing a nuanced and holistic perspective on unpaid caregiving experiences.

A comprehensive review on role of magnetic resonance imaging in the precise measurement of corpus callosum

Magnetic Resonance Imaging (MRI) has emerged as a powerful and non-invasive imaging technique, playing a pivotal role in neuroimaging research and clinical diagnosis. This comprehensive review explores the significance of MRI in the precise measurement of the corpus callosum, a key structure connecting the two hemispheres of the brain. The corpus callosum plays a crucial role in inter hemispheric communication and is implicated in various neurological and psychiatric disorders. The review begins by elucidating the anatomy and functions of the corpus callosum, emphasizing its importance in facilitating seamless communication between the cerebral hemispheres. Subsequently, the paper delves into the historical evolution of MRI techniques and how advancements have enhanced the visualization and measurement capabilities of the corpus callosum. A detailed examination of various MRI modalities, including structural MRI, diffusion tensor imaging (DTI), and functional MRI, is presented in the context of corpus callosum analysis. Structural MRI provides high-resolution images for accurate morphological assessments, while DTI offers insights into white matter microstructure and fiber tractography, allowing for a more comprehensive understanding of the corpus callosum's integrity. The review also highlights the role of MRI in investigating alterations in the corpus callosum associated with neurological disorders such as multiple sclerosis, epilepsy, and neurodevelopmental disorders. Additionally, the paper explores how functional MRI contributes to understanding the functional connectivity and inter hemispheric interactions mediated by the corpus callosum. Challenges and limitations in the measurement of the corpus callosum using MRI are discussed, including methodological considerations, image artifacts, and potential sources of variability. The review concludes by outlining future directions in corpus callosum imaging research, including the integration of advanced imaging techniques, artificial intelligence, and large-scale multi-center studies to enhance the precision and reliability of measurements.In summary, this comprehensive review underscores the pivotal role of MRI in advancing our understanding of the corpus callosum, providing valuable insights into both normal brain function and pathological conditions. The continual evolution of MRI techniques holds promise for further refining the assessment of the corpus callosum, ultimately contributing to improved diagnostic accuracy and therapeutic interventions in neurological and psychiatric disorders.

Developing conceptual framework and methodological considerations in community-supported chronic disease management

Developing conceptual framework and methodological considerations in community-supported chronic disease management

Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications.

Type 2 diabetes mellitus (T2DM) is a global health concern with significant implications for vascular health. The current evaluation methods cannot achieve effective, portable, and quantitative evaluation of foot microcirculation. We aim to use a wearable device laser Doppler flowmetry (LDF) to evaluate the foot microcirculation of T2DM patients at rest. Eleven T2DM patients and twelve healthy subjects participated in this study. The wearable LDF was used to measure the blood flows (BFs) for regions of the first metatarsal head (M1), fifth metatarsal head (M5), heel, and dorsal foot. Typical wavelet analysis was used to decompose the five individual control mechanisms: endothelial, neurogenic, myogenic, respiratory, and heart components. The mean BF and sample entropy (SE) were calculated, and the differences between diabetic patients and healthy adults and among the four regions were compared. Diabetic patients showed significantly reduced mean BF in the neurogenic () and heart () components at the M1 and M5 regions () compared with healthy adults. Diabetic patients had significantly lower SE in the neurogenic () and myogenic () components at the M1 region, as well as in the endothelial () component at the M5 region and in the myogenic component at the dorsal foot (), compared with healthy adults. The SE in the myogenic component at the dorsal foot was lower than at the M5 region () and heel area (). Similarly, the SE in the heart component at the dorsal foot was lower than at the M5 region () and heel area () in diabetic patients. This study indicated the potential of using the novel wearable LDF device for tracking vascular complications and implementing targeted interventions in T2DM patients.

Methodological Considerations Regarding the Quantification of DNA Impurities in the COVID-19 mRNA Vaccine Comirnaty®.

DNA impurities can impact the safety of genetically engineered pharmaceuticals; thus, a specific limit value must be set for them during marketing authorisation. This particularly applies to mRNA vaccines, as large quantities of DNA templates are used for their production. Furthermore, when quantifying the total DNA content in the final product, we must observe that, in addition to the mRNA active ingredient, DNA impurities are also encased in lipid nanoparticles and are therefore difficult to quantify. In fact, the manufacturer of the mRNA vaccine Comirnaty (BioNTech/Pfizer) only measures DNA impurities in the active substance by means of a quantitative polymerase chain reaction (qPCR), whose DNA target sequence is less than just 1% of the originally added DNA template. This means that no direct DNA quantification takes place, and compliance with the limit value for DNA contamination is only estimated from the qPCR data using mathematical extrapolation methods. However, it is also possible to dissolve the lipid nanoparticles with a detergent to directly measure DNA contamination in the final product by using fluorescence spectroscopic methods. Experimental testing of this approach confirms that reliable values can be obtained in this way.

Artificial intelligence in epilepsy - applications and pathways to the clinic.

Artificial intelligence (AI) is rapidly transforming health care, and its applications in epilepsy have increased exponentially over the past decade. Integration of AI into epilepsy management promises to revolutionize the diagnosis and treatment of this complex disorder. However, translation of AI into neurology clinical practice has not yet been successful, emphasizing the need to consider progress to date and assess challenges and limitations of AI. In this Review, we provide an overview of AI applications that have been developed in epilepsy using a variety of data modalities: neuroimaging, electroencephalography, electronic health records, medical devices and multimodal data integration. For each, we consider potential applications, including seizure detection and prediction, seizure lateralization, localization of the seizure-onset zone and assessment for surgical or neurostimulation interventions, and review the performance of AI tools developed to date. We also discuss methodological considerations and challenges that must be addressed to successfully integrate AI into clinical practice. Our goal is to provide an overview of the current state of the field and provide guidance for leveraging AI in future to improve management of epilepsy.

Customer-Perceived Innovation: Considerations for Financial Performance and Methodological Approaches

As firms increasingly uncover their activities to key stakeholders through various media, the perception of these activities is becoming more important for firm performance. Traditionally, access to industry-wide databases provides important metrics on customer perceptions of performance, such as customer satisfaction and brand equity. In addition, numerous studies have highlighted firms' innovation-related actions (e.g., R&D spending and patent counts) as critical metrics linked to their financial performance. Perceived Firm Innovation (PFI) emerges as a relatively new and under-studied metric with the potential to impact a firm's financial success. Keiningham et al. are among the pioneers in this area. This commentary views their article as a vital initial step in understanding PFI’s impact. Considering that the service sector accounts for over 70 percent of the GDP in any developed country, service innovation is a broad phenomenon. Given the breadth of the area, we point to the challenge of capturing this phenomenon with a single metric like PFI. We also discuss crucial methodological considerations for future research, including estimation methods, sample size, and financial metrics.

Physical Exercise to Redynamize Interoception in Substance use Disorders.

Physical exercise is considered a promising medication-free and cost-effective adjunct treatment for substance use disorders (SUD). Nevertheless, evidence regarding the effectiveness of these interventions is currently limited, thereby signaling the need to better understand the mechanisms underlying their impact on SUD, in order to reframe and optimize them. Here we advance that physical exercise could be re-conceptualized as an "interoception booster", namely as a way to help people with SUD to better decode and interpret bodily-related signals associated with transient states of homeostatic imbalances that usually trigger consumption. We first discuss how mismatches between current and desired bodily states influence the formation of reward-seeking states in SUD, in light of the insular cortex brain networks. Next, we detail effort perception during physical exercise and discuss how it can be used as a relevant framework for re-dynamizing interoception in SUD. We conclude by providing perspectives and methodological considerations for applying the proposed approach to mixed-design neurocognitive research on SUD.

Research and practice priorities in pilonidal sinus disease: a consensus from the PITSTOP study.

Pilonidal sinus disease is a common condition treated by colorectal surgeons. There is a lack of literature in the field to guide optimal management of this condition. As part of the PITSTOP study, we aimed to identify policy and research priorities to provide direction to the field. Patients and surgeons were invited to participate. A 'So what, now what' exercise was conducted, informed by data from PITSTOP. This generated statements for research and practice priorities. A three-round online Delphi study was conducted, ranking statements based on policy and research separately. Statements were rated 1 (not important) to 9 (important). Statements that were rated 7-9 by more than 70% of participants were entered into the consensus meeting. Personalized voting feedback was shown between rounds. A face-to-face meeting was held to discuss statements, and participants were asked to rank statements using a weighted choice vote. Twenty-two people participated in the focus group, generating 14 research and 19 policy statements. Statements were voted on by 56 participants in round 1, 53 in round 2 and 51 in round 3. A total of 15 policy statements and 19 research statements were discussed in the consensus round. Key policy statements addressed treatment strategies and intensity, surgeon training opportunities, need for classification and the impact of treatment on return to work. Research recommendations included design of future trials, methodology considerations and research questions. This study has identified research and policy priorities in pilonidal sinus disease which are relevant to patients and clinicians. These should inform practice and future research.

Population and Target Population in Research Methodology

This paper thoroughly explores the foundational principles governing population and target population concepts within research methodology. It delves into the essential roles these concepts play in shaping the design and influencing the interpretation of research studies. Through an exhaustive analysis, it meticulously outlines the nuances that differentiate these two concepts, elucidating their respective contributions and implications across diverse research paradigms. Moreover, this paper underscores the importance of establishing clear definitions and boundaries for both the population and the target population. It emphasises how such precision is indispensable in guiding the formulation of effective sampling strategies, which are pivotal for ensuring the accuracy and reliability of study outcomes. Furthermore, it sheds light on how the clarity in defining these concepts significantly impacts the generalizability of research findings, elucidating how findings derived from a well-defined target population can be more confidently extrapolated to broader populations. In addition to methodological considerations, this paper investigates the ethical dimensions inherent in delineating population and target population. It underscores the moral imperative of accurately representing the groups under study, particularly ensuring equitable access to research participation and safeguarding against potential biases.

Qualche nota e interrogativo intorno a nuove prospettive di ricerca sul magistero romano a metà Novecento

This paper proposes some considerations through a cross-reading of the articles published in this issue. The new research reveals several protagonists of the curial environment in the elaboration of Pius XII’s magisterial documents: the consultors at the Holy Office Franz Hürth, Sebastiaan Tromp, the better-known Augustin Bea; the secretary of Briefs to Princes Antonio Bacci. The role of the Society of Jesus is also relevant: it is able to mitigate or deflect curial proceedings initiated against its members. The articles add important contributions to our knowledge of Pius XII’s modus operandi at the head of the Catholic Church, with the support of his main collaborators (Montini, Dell’Acqua) and in the context of the internal dialectics within the Holy See. At the doctrinal level, the question of modernism and its new expressions appeared central throughout Pacelli’s pontificate. The text also offers some methodological considerations regarding contemporary research in the field of the history of Christianity and the Churches.

Prevalence of chronic kidney disease in France: methodological considerations and pitfalls with the use of Health claims databases.

Health policy-making require careful assessment of chronic kidney disease (CKD) epidemiology to develop efficient and cost-effective care strategies. The aim of the present study was to use the RENALGO-EXPERT algorithm to estimate the global prevalence of CKD in France. An expert group developed the RENALGO-EXPERT algorithm based on healthcare consumption. This algorithm has been applied to the French National Health claims database (SNDS), where no biological test findings are available to estimate a national CKD prevalence for the years 2018-2021. The CONSTANCES cohort (+219 000 adults aged 18-69 with one CKD-EPI eGFR) was used to discuss the limit of using health claims data. Between 2018 and 2021, the estimated prevalence in the SNDS increased from 8.1% to 10.5%. The RENALGO-EXPERT algorithm identified 4.5% of the volunteers in the CONSTANCES as CKD. The RENALGO-EXPERT algorithm had a positive predictive value of 6.2% and negative predictive value of 99.1% to detect an eGFR<60ml/min/1.73m². Half of 252 false positive cases (ALGO+, eGFR>90) had been diagnosed with kidney disease during hospitalization, and the other half based on healthcare consumption suggestive of a 'high-risk' profile; 95% of the 1661 false negatives (ALGO-, eGFR<60) had an eGFR between 45 and 60ml/min, half had medication and two-thirds had biological exams possibly linked to CKD. Half of them had a hospital stay during the period but none had a diagnosis of kidney disease. Our result is in accordance with other estimations of CKD prevalence in the general population. Analysis of diverging cases (FP and FN) suggests using health claims data have inherent limitations. Such an algorithm can identify patients whose care pathway is close to the usual and specific CKD pathways. It does not identify patients who have not been diagnosed or whose care is inappropriate or at early stage with stable GFR.

Postdigital ethnography in applied linguistics: Beyond the online and offline in language learning

We live in a postdigital world where traversing digital and in-person domains for teaching and learning is normalized, raising important methodological and ethical considerations for ethnographic approaches in language education. We define postdigital as a condition where the virtual and physical mediate each other to form hybrid spaces that transcend the online/offline distinction. We begin the article with theoretical discussions on the epistemological orientations that inform postdigital inquiry. Then we situate our language education research, discussing the value of ethnography for understanding hybrid spaces and identifying the challenges and limitations of existing ethnographic methodologies in addressing postdigital conditions. Following this, we illustrate ways to follow the chosen unit of analysis in postidigital ethnography through three case studies, specifically focusing on pedagogical activities. We also reflect on pedagogical insights from postdigital ethnography, sensitive ethical concerns involved in postdigital research, as well as considerations for addressing those ethical issues. We conclude the paper with practical suggestions for researchers on conducting postdigital ethnographies.

Application of causal inference methods in individual-participant data meta-analyses in medicine: addressing data handling and reporting gaps with new proposed reporting guidelines

Observational data provide invaluable real-world information in medicine, but certain methodological considerations are required to derive causal estimates. In this systematic review, we evaluated the methodology and reporting quality of individual-level patient data meta-analyses (IPD-MAs) conducted with non-randomized exposures, published in 2009, 2014, and 2019 that sought to estimate a causal relationship in medicine. We screened over 16,000 titles and abstracts, reviewed 45 full-text articles out of the 167 deemed potentially eligible, and included 29 into the analysis. Unfortunately, we found that causal methodologies were rarely implemented, and reporting was generally poor across studies. Specifically, only three of the 29 articles used quasi-experimental methods, and no study used G-methods to adjust for time-varying confounding. To address these issues, we propose stronger collaborations between physicians and methodologists to ensure that causal methodologies are properly implemented in IPD-MAs. In addition, we put forward a suggested checklist of reporting guidelines for IPD-MAs that utilize causal methods. This checklist could improve reporting thereby potentially enhancing the quality and trustworthiness of IPD-MAs, which can be considered one of the most valuable sources of evidence for health policy.

Facebook recruitment: understanding research relations Prior to data collection

ABSTRACT This article considers the multiple relations that emerge from and between Facebook commenters, as well as between commenters, researchers, and the research project during recruitment. To do so, we draw on our experiences of recruiting individuals who have concerns about or are opposed to a range of recent social and legal changes in ‘post-equality’ contexts. Understanding research as co-created rather than ‘collecting data from’ participants, we consider the researcher, commenters, and Facebook technologies as active agents, and ask how the emergent relationalities between these agents shapes the social media recruitment process. We develop thinking regarding these relationalities through an in-depth exploration of our processes that reveal key methodological considerations relevant to social media recruitment in the social sciences. As the process of recruitment is mutually constructed online through multiple relationalities across researcher/project and commenter, as well as between commenters themselves, we conclude that there is a need for dynamic, iterative, and reflexive responses and engagements rather than pre-defined frameworks.