Wet Granulation Method Research Articles

Development and Evaluation of Carminative Herbal Chewable Tablets Based on Turmeric, Fennel Seed, and Mango Ginger

The present study aimed at the formulation of carminative herbal chewable tablets using herbal constituents. Curcuma longa (turmeric), Foeniculum vulgare (fennel), and Curcuma amada (mango ginger) are the most celebrated herbs in Indian system of traditional medicine. In the present research work, oral chewable tablets were prepared by direct compression and wet granulation method incorporating these three herbs. In both the methods, the powder of turmeric, fennel seed, and ginger mango was prepared initially and it was mixed with additives and preservatives. Physicochemical analysis of the individual drugs, pre-formulation studies, and post-formulation standardization was done to evaluate the quality and purity of the conformation. In the pre-formulation study, it was observed that all the parameters checked for the ingredients were within standard range. Thus, the ingredients were processed for preparing tablets following IP. During the evaluation of tablets, it was found that all the prepared batches of tablets were within the standard range of chewable tablet parameters. Thus, considering these values and following the IP, we found that the chewable tablet that was prepared without altering its therapeutic property was satisfactory with general characteristics of tablet, namely, hardness, disintegration time, friability, and weight variation. The formulation was tested for common people with respect to taste; odor and time required for complete chewing and showed that it can be accepted for the present trends of newer drug delivery dosage forms. The present study provides an approach to come up with a modern outlook to traditional folklore formulations without altering its therapeutic property which is highly essential in industrial applications and to meet consumer preferences and demands. Therefore, it is concluded that the developed chewable tablets may be better alternative to the conventional uses of the herbs.

Formulation and evaluation of Kirinyuh Leaf effervescent granules (Chromolaena Odorata. L) as an antioxidant

Introduction: Kirinyuh leaf is a widely grown plant in Indonesia, containing alkaloids, flavonoids, saponins, tannins, and steroids. Flavonoids are compounds that can capture free radicals or act as natural antioxidants. Effervescent granules can mask the bitter taste and simplify the dissolving process without involving manual stirring. Aim: The purpose of this study was to make and evaluate a formulation of effervescent granules of Kirinyuh leaf extract. Methods: The granule method was carried out by the wet granulation method. Granule evaluation included organoleptic test, water content test, dissolve time test, flow time test, pH test, and hedonic test. Results: Organoleptic test results showed similar granule size, slightly brownish colour, and characteristics of Kirinyuh leaf odour. When examining their quality, the granules produced met the requirements, with moisture content between 0.4% and 0.7%, dissolving time of 30-35 seconds, flow time test of 8-8.5 g/second, and pH of 5.6-5.8; the results of the hedonic test showed that the effervescent granule preparation was much preferred.

The potential of banana fruit Ranggap (Musa paradisiaca var. Troglodytarum) as an excipient alternative to oral tablet dosage form


 Introduction: Starch is one of the ingredients that has many benefits, including in the pharmaceutical field, especially as a pharmaceutical excipient in pharmaceutical formulations. 
 Aim: This study aims to isolate, characterise, and formulate the starch of banana fruit (Musa paradisiaca var. Troglodytarum) into tablet dosage forms. 
 Methods: The characteristics of the perceived banana starch can be said to be comparable to that of corn starch so that it is expected to be used as a source of starch which can be used as a pharmaceutical excipient. The starch of isolated banana fruit was used as a filler, binder, and crusher in the wet granulation method tablet formulations with concentrations of 2%, 3%, and 5%. 
 Results: The physicochemical characteristics of starch isolated from banana fruit are considered to meet the requirements of pharmaceutical excipients required in the Handbook of Pharmaceutical Excipients 6th edition and the United States Pharmacopeia 32nd edition. 
 Conclusion: Of the total formulas tested, tablets with binder content of banana starch 3%, 5% and 10% corn starch meet the tablet evaluation requirements.

The potential of banana fruit Ranggap (Musa paradisiaca var. Troglodytarum) as an excipient alternative to oral tablet dosage form

Introduction: Starch is one of the ingredients that has many benefits, including in the pharmaceutical field, especially as a pharmaceutical excipient in pharmaceutical formulations. Aim: This study aims to isolate, characterise, and formulate the starch of banana fruit (Musa paradisiaca var. Troglodytarum) into tablet dosage forms. Methods: The characteristics of the perceived banana starch can be said to be comparable to that of corn starch so that it is expected to be used as a source of starch which can be used as a pharmaceutical excipient. The starch of isolated banana fruit was used as a filler, binder, and crusher in the wet granulation method tablet formulations with concentrations of 2%, 3%, and 5%. Results: The physicochemical characteristics of starch isolated from banana fruit are considered to meet the requirements of pharmaceutical excipients required in the Handbook of Pharmaceutical Excipients 6th edition and the United States Pharmacopeia 32nd edition. Conclusion: Of the total formulas tested, tablets with binder content of banana starch 3%, 5% and 10% corn starch meet the tablet evaluation requirements.

Tablet Formula Optimization From Helminthostachys Zaylanica Extract Using A Simplex Lattice Design

Helminthostachys zeylanica extract has pharmacological activities such as antioxidant, antiinflamatory, and antihyerucemia. This extract is nontoxic substance from the acute and subchronic toxicity tests. This extract has a potency to be formulated into tablet dosage forms. This study aims to optimize a tablet formula from Helminthostachys zeylanica extract. Disintegrant and binder concentrations were independent variables, while physical properties and dissolution time of the tablets were dependent variables. The tablet was prepared by a wet granulation method. Formula was optimized by Simplex Lattice Design. Physicochemical propertiesof granule, physical properties and dissolution of tablet were then analyzed with One Way ANOVA (p = 0.05). Based on granule analysis, specification of physicochemical parameters, such as hausner’s ratio, compressibility index, flowability, repose angle, and water content, met standard British Pharmacopeia. In addition, the starch and PVA concentrations influenced thickness, weight variation, hardness, friability, disintegration time and dissolution of the tablets (p <0.05), except for friability (p> 0.05). Based on this study, the starch and PVA concentrations for the optimum tablet formula were 19.5% and 1.05%, respectively.

Effect of Hydroxypropyl Methylcellulose and Microcrystalline Cellulose in Design and Optimization of Nebivolol Hydrochloride Immediate Release Tablets by Response Surface Methodology

The goal of the research is to design and optimize Nebivolol Hydrochloride immediate-release tablet using response surface methodology. Nebivolol Hydrochloride immediate-release tablets used in the treatment of heart attacks, myocardial infarction. Response surface methodology calculations for this optimization study were performed utilizing Minitab 17. Different formulations of immediate-release were prepared by applying 2 factors 3 levels full factorial design using Minitab 17, which gave 9 formulations by using the wet granulation method. Independent variables like the amount of hydroxypropyl methylcellulose (X1), and microcrystalline cellulose (X2) and dependent variables like the per cent drug release at 45 minutes (Y1), disintegration (Y2) were selected for optimization. The prepared batches of Nebivolol Hydrochloride immediate-release tablets were evaluated for the pre-compression and post-compression parameters like weight variation, thickness, hardness, and friability, disintegration, and in-vitro drug release studies. All the Physico-chemical parameters were found satisfactory for prepared tablets. The optimized formulation F7 showed disintegrated in 83 sec, percentage dissolution release 97.85 at the end of 45th minute. The results shows that formulated immediate-release tablets of Nebivolol HCl were better to meet patient compliance with respect to effectiveness.

Evaluating the Flow and Release Profiles of Ibuprofen Formulations by Increasing the Binder Concentration

Background: Tablets must be able to release the active drug in the gastrointestinal tract for absorption. The release profile of solid pharmaceutical dosage formulations can be quantified by assessing the disintegration and dissolution times tests. Binders are adhesives either from sugar or polymeric material that are added to tablet formulations to provide the cohesiveness required for the bonding together of the granules under compaction to form tablets.Objective: The objective of the study was to formulate and assess ibuprofen tablets using different concentrations of binders (Acacia and Gelatin).Methods: The granules were prepared using wet granulation method and analysed for flow properties based on USP/NF protocols. After granule compression, the tablets release profiles were thereafter assessed via the tablet dissolution and disintegration tests.Results: Weight variation, thickness and diameter were within the acceptable values for all batches indicative of a uniform flow. Batches with binder concentrations of 10 % and 20 % failed disintegration test due to a disintegration time above 15 min while the release rate for batches 1 and 4 was about 88 % in 60 min as against the other batches whose release rate was less than 50 % in 60 min as a result of increasing their binder concentrations.Conclusion: The study concluded that increasing the concentration of acacia and gelatin above 5% led to a decrease in percentage of drug released and an increase in disintegration time above 30 mins because 5% batches gave the best release profiles.

DESIGN AND EVALUATION OF HERBAL HEPATOPROTECTIVE MATRIX TABLET CONTAINING METHANOLIC EXTRACT OF CORDIA DICHOTOMA LEAVES

Cordia dichotoma, belonging to the family Boraginaceae, is a medium sized tree with a short, usually crooked trunk, which is found throughout India. C. dichotoma is beneficial in conditions of liver disease and inflammation. The present investigation was designed to develop a sustained release herbal matrix tablet containing C. dichotoma leaves extract for the treatment of liver disorders by exploiting the knowledge of the traditional system of medicine. Three herbal tablet formulations of methanolic extract of C. dichotoma were developed by the wet granulation method using the blend of hydrophilic and hydrophobic polymers like HPMC E-5, sodium carboxymethyl cellulose, Poloxamer 188, and ethyl cellulose. The tablets were evaluated for physicochemical properties and in vitro release study followed by stability testing to assess its shelf life. In vitro hepatoprotective effect was also studied, which is based on protection of human liver-derived HepG2 cells against CCl4 exposed toxicity. Physicochemical properties were found to be within limits. The percentage of drug release after 12 h was found to be 75.65, 79.75, and 82.49 for formulation F-1, F-2 and F-3, respectively. The proposed study demonstrates that developed herbal matrix tablet can serve as a successful sustained drug delivery system with the added benefit of no side effects for control and cure of chronic conditions of the liver.

Comprehensive Review on Ficus Deltoidea Effervescent Mouthwash Formulation in Treating Oral Pathogens

Ficus deltoidea or its well-known local name Mas Cotek belongs to the family of Moracaeae. This native plant is commonly found in Malaysia, other tropical and subtropical countries. Oral periodontal disease is an alarming disease and the utilization of herbal plants in treating oral pathogens has raised attention and concern. Therefore the main objective of this study was to review the effectiveness of effervescent mouthwash formulation of the FDL on treating oral pathogens. Plaque accumulation and oral microorganisms are the main predisposing factors to oral periodontal diseases. Herbal mouthwash has been of particular interest these days to treat oral pathogens. Different effervescent agents such as citric acid, tartaric acid, and sodium bicarbonate were used in formulating effervescent mouthwash by different methods with varying concentrations. FDL leaves have claimed to possess different properties such as antioxidant, anti-diabetic, and anti-inflammatory properties which are helpful in treating many diseases. Post compression parameters such as effervescent time, moisture content, and in vitro antibacterial test were reviewed in this study. FDL has shown a strong correlation to the presence of high content of polyphenols, flavonoids, saponin, tannins, and triterpenoids. In conclusion, the type of preparation choosen is by using wet granulation method and the suitable ratio is 2:1.

Design and Evaluation of Press Coated Formulation of Aceclofenac and Comparison with Marketed Preparations.

The primary objective of the studies is to investigate whether compression coating could be used to produce tablets providing maximum drug plasma concentration 6 to 8 hours after an evening dose taken at approximately 22:00. Fast Dispersible core tablets containing Aceclofenac were prepared using super disintegrants like Ac-Di-Sol, Crospovidone, and Sodium starch glycolate through wet granulation method and evaluated for various parameters. Prepared press-coated tablets were characterized for physical parameters, drug content, lag time, in vitro drug release characteristics. Aceclofenac formulation tablets of batch F4 containing combination Methocel K4M and Methocel K100M showed desired lag time along with drug release as compared to other formulations. The Comparative dissolution study of an optimized formulation containing Aceclofenac was carried with marketed preparations also showed good results.

Formulation and Evaluation of Two Types of Functional Beverage Granules Made of Extracts of Guava Leaves, Purple Sweet Potato and Cinnamon

Functional foods are bioactive compounds that have the potential to provide health benefits beyond the basic nutritional values. This study was conducted to formulate and evaluate functional beverage granules with the use of guava leaves, purple sweet potatoes, and cinnamons as functional herbal-based food. Granules from the ethanol extracts of guava leaves and purple sweet potatoes were prepared with three different ratios: Formulas 1 (3:2 %), 2 (3:2.5 %), and 3 (3:3 %). Also, ethanol extracts of guava leaves and cinnamons were formulated with three different ratios: Formulas I (3:1 %), II (3:2 %), and III (3:3 %). These granules were formulated by the wet granulation method, and then their characteristics were evaluated. The results showed that the functional beverage granules made of guava leaves and purple sweet potatoes had % fines of 1.52±0.55‒6.04±0.06, moisture contents of 1.51±0.10‒2.06±0.12%, flow rates at 9.34±0.77–10.89±0.32 g/sec, angles of repose at 29.64 ± 0.67‒30.70±1.55, compressibility index of 16.19±0.82‒17.32±3.43%, and Hausner ratio of 1.20±0.01–1.22±0.03. Meanwhile, those made of guava leaves and cinnamons had % fines of 1.63±0.49‒1.85±0.81, moisture contents of 0.71±0.10‒1.06±0.02 %, flow rates at 7.93±0.44–8.61±0.74 g/sec, angles of repose at 20.95±1.56–31.17±1.29, compressibility index of 19.56±1.32‒20.37±1.32%, and Hausner ratio of 1.24±0.02–1.25±0.02. All granule formulas containing guava leaves and purple sweet potatoes met the predefined specifications. Conversely, the granule formulas containing guava leaves and cinnamons did not meet the standard specification.

Formulation and Evaluation of Triclosan Dispersible Tablets for Oral Hygiene

In human anatomy mouth is the earliest segment of alimentary canal which receives food and fabricates saliva, and is one of the foundation for bacterial development due to accretion of sugars form food chunks. There have been more than 300 kinds of bacteria set up in the mouth. The purpose of the present study is to investigate the number of microbes’ grown-up at different timings of the day by collecting the samples from individual volunteer oral cavities and counting the colonies; the utmost count was noted as in the range of 190-200 in the evening samples. The same samples were used to calculate minimum inhibitory concentration of Triclosan, the antibiotic formulated for oral hygiene. Triclosan dilutions were prepared and analyzed for the inhibition zones, it resulted that 300mg of the drug have shown satisfactory results. Triclosan was formulated into a dispersible tablet to enable dispersion of tablet into water for rinsing the oral cavity to remove the contaminants. The Dispersion time of the tablet was within the range of 43.66-111.33 second and it was observed that formulation was acceptable with reasonable limits of standard required for dispersible tablets. Addition of superdisintegrant enhanced the dispersion time which facilitates easy mixing of tablet in water. It concludes that superdisintegrant addition technique is a useful method for preparing dispersible tablets by wet granulation method, and Triclosan dispersible tablet further reduces the microbial attack on tooth by rinsing each time after meals, upon doing so on long term basis the dental decays will probably be eradicated.

CaCO3-Chitosan Composites Granules for Instant Hemostasis and Wound Healing.

Excessive bleeding induces a high risk of death and is a leading cause of deaths that result from traffic accidents and military conflict. In this paper, we developed a novel porous chitosan–CaCO3 (CS–CaCO3) composite material and investigated its hemostatic properties and wound healing performance. The CS–CaCO3 composites material was prepared via a wet-granulation method. Granulation increases the infiltrating ability of the CS–CaCO3 composites material. The improved water absorption ability was enhanced to 460% for the CS–CaCO3 composites material compared to the CaCO3 or chitosan with only one single component. The coagulation studies in vivo illustrated that the blood clotting time was greatly reduced from 31 s for CaCO3 to 16 s for the CS–CaCO3 composite material. According to the results of the wound healing experiments in rats, it was found that the CS–CaCO3 composite material can promote wound healing. The CS–CaCO3 composite material could accelerate wound healing to a rate of 9 days, compared with 12 days for the CaCO3. The hemostatic activity, biocompatibility, and low cost of CS–CaCO3 composite material make it a potential agent for effective hemostatic and wound healing materials.

Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis Pengisi sebagai Diluent menggunakan Metode Granulasi Basah

Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose, lactose. Formula I mannitol, formula II sucrose, and formula III lactose. Chewable tablet preparations are made by the wet granulation method. Data collection was performed on physical characteristics including organoleptic, weight uniformity, uniformity of size, tablet hardness, tablet fragility, disintegration time, metoclopramide HCl levels. Physical quality test results were statistically analyzed to determine the effect of variations in the diluent on the characteristics of chewable tablets. The results of this research have an influence on the physical quality and uniformity of contents of various types of diluent variations between each formulation. In this research, fillers have an important role in the preparation of chewable metoclopramide tablets to determine the physical quality of the tablets and the uniformity of their contents. The variation of diluent that gives better results is mannitol. This is because formulas that use mannitol have uniformity in content that meets the requirements, faster disintegration time, and physical quality of tablets that still meet the requirements, when compared to the first and second formulations. The variation of diluent that gives better results is mannitol.

OPTIMASI CAMPURAN AVICEL PH 101 DAN LAKTOSA SEBAGAI BAHAN PENGISI PADA TABLET EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa L.) SECARA GRANULASI BASAH

Rosella flower (Hibiscuss sabdariffa L.) in traditional medicine can provide protection against various diseases, such as coronary heart disease, cancer, lowering cholesterol, and liver disorders. This study aims to obtain the optimum formula of tablet of rosella flower extract with a mixture of Avicel PH 101 and lactose as a filler using wet granulation method. Rosella flower extract was obtained by maceration of rosella flower powder using 70% ethanol. The optimization formula for tablets using the Simplex Lattice Design method with Design Expert software version 10. The parameters used in the optimization are weight variation, hardness, friability and disintegration time. Verification of the optimal formula using the SPSS 18 program with the One Sample T-test method with a confidence level of 95%. The results showed that the optimal formula of tablet of rosella flower extract was the Avicel PH 101 97.82%: 2.17% lactose. The optimal formula has weight variation 1.53% ± 0.0073; hardness 5.087 kg ± 0.5135; the friability is 0.3% ± 0.041. The resulting disintegration was 22.99 minutes ± 2.218. The results of the verification of the optimal formula show that there is no significant difference between the predictions of the Simplex Lattice Design method and the results of the tests performed so that it can be said that the method is valid.

Formulation and Evaluation of Sustained Release Matrix Tablets of Aceclofenac

This study aimed to improve the dissolution rate of aceclofenac and release the drug in a controlled manner over a period of 24 hours. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/guar gum). Matrix tablets were prepared by wet granulation method using different hydrophilic polymers (HPMC/guar gum). Tablets were evaluated for in vitro drug release profile in phosphate buffer with pH 6.8 (without enzymes). The thickness and hardness of prepared tablets were 3.23 ± 0.035 to 3.28 ± 0.008 mm and 3.26 ± 0.115 to 3.60 ± 0.200 kg/cm2, respectively. The friability was within the acceptable limits of pharmacopoeial specifications (0.31 to 0.71%), which indicates the good mechanical strength of the tablets. Drug release was retarded with an increase in polymer concentration due to the gelling property of polymers. The in vitro drug release from the proposed system was best explained by Higuchi’s model, indicating that drug release from tablets displayed a diffusion-controlled mechanism. The results clearly indicate that guar gum could be a potential hydrophilic carrier in developing oral controlled drug delivery systems. Based on the study results, formulations F8 was selected as the best formulation.

Development and In‑Vitro Evaluation of Colon Specific Indomethacin Matrix Tablet for the Treatment of Inflammatory Bowel Disease

IBD is a chronic inflammatory disease of the gastrointestinal tract, particularly small and large intestine consisting of ulcerative colitis (UC) and Crohn’s disease (CD). Oral route of drug delivery is considered as the most appropriate route of drug delivery of drugs. But this route has certain limitations of poor bioavailability due to gastric degradation and increase in dose size and frequency. Therefore, the present aim of the study is to prepare and evaluate Indomethacin loaded matrix tablet using guar gum, HPMC (release controlling polymer) and citric acid to facilitate the drug solubility in the colon. A total 8 different formulations were prepared by wet granulation method and coated with Eudragit S 100 polymer a pH dependent enteric coating polymer which dissolve at colonic pH (7.4) and specifically release the drug in the colon region in sustain release fashion. The granules evaluated for its micrometrics properties and tablets were evaluated for its hardness, thickness, friability, weight variation, drug content, and in‑vitro drug release studies. The % cumulative drug release profile of all tablets was little and insignificant at pH 1.2 and 6.8. In colonic pH the coating dissolves tablets starts to release drugs. Among all the formulation the formulation F3 having guar gum and HPMC ratio 3:1 shows a maximum release of drug of 80.41±6.5%. At 24 h. The study demonstrated that the prepared tablets can release the Indomethacin in sustained release manner and helps in management of IBD with reduced side effect of the therapy. The results of this study show that oral administration of aspartame (250mg/kg body weight) was correlated to a significant increase in the lipid profile, fasting blood glucose and some marker enzymes and this increase is time related.

Central Composite Design Aided Formulation Development and Optimization of Clarythromycin Extended-Release Tablets

Abstract: Objectives: The present work was designed to formulate extended-release tablets of clarithromycin by means of central composite design. To assess the systematic considerate of input and output variables and to construct design space, the central composited design was used. Methods: The concentrations of tamarind kernel powder (X1), ethyl cellulose (X2) and polyvinyl pyrrolidone (X3) remained as independent variables and responses were drug release in 2 h, 8 h and t50%. Polynomial equations were employed to forecast the quantitative result of nondependent constraints at different levels on responses. The model stood nonlinear and the curvature outcome was significant. Henceforth the study employed central composite design for optimization. Wet granulation method was used to prepare the tablets and were evaluated for pharmacotechnical properties. Results: FTIR and DSC studies signposted that drug and excipients were compatible. Precompression constraints specified respectable flow properties. The in vitro drug release of entire formulations at the end of 12 h was found to be 96.14% - 98.23%. Increase in the concentration of tamarind kernel powder, ethyl cellulose decreased percentage drug release. Contour plots were utilized to assess the relationship between independent variables and dependent variables. Conclusion: The statistical model is scientifically effective as the investigational estimates and foreseen estimates proposed by the model were relatively close to each other. The outcomes confirmed the success of the anticipated design for development of clarithromycin extended-release tablets with optimized properties. Key words: Tamarind kernel powder, Ethyl cellulose, Polyvinyl pyrrolidone, Clarithromycin, Central composite design, Extended release.

COLOCASIA ESCULENTA STARCH: NOVEL ALTERNATIVE DISINTEGRANT FOR PHARMACEUTICAL APPLICATION

Oral drug delivery system has always been the most prevalent route of administration and continuous efforts are made to improve the drug delivery by this route. Tablets are one of the most extensively used dosage forms and various excipients have been developed for their formulation. The purpose of the current research work was to isolate and study the physicochemical properties of the Colocasia esculenta starch and further compare its disintegration ability with maize starch. Starch was isolated from C. esculenta corms by aqueous extraction method and possesses characteristics that are typical of starches. It was further evaluated for the presence of other foreign matter and phytoconstituents. Results showed that the isolated sample was free from foreign organic matter and the total ash value was found to be 0.4%. Tablets were prepared by the wet granulation method by varying concentrations in the range of 2.5 to 10% w/w for both the starches. Pre and post-compression parameters were studied and were found to be within the pharmacopoeial limits. Disintegration tests showed that disintegration time decreases with increasing concentration of both the starches. At 10% w/w concentration, disintegration time was found to be lowest, hence it was selected as an optimized formulation Stability studies were performed on F4 batch and it was found to be stable. The determination of disintegration efficiency indicates that C. esculenta starch exhibits disintegrating potential.

FORMULATION, CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF METADOXINE TABLETS PREPARED BY VARIOUS GRANULATION METHODS

Pharmaceutical tablets are robust, flat, or biconvex dishes, according to the Indian Pharmacopoeia. Depending on a range of medicinal substances, they vary in shape and differ greatly in size and weight. In the era of increasing health awareness and strict standards set by regulatory authorities such as the US FDA, WHO, and globalization, it has become mandatory for the producer to launch a product cost-effectively. In the tablet dosage form, two classes of drugs are administered orally. Narrow extensions of the parietal peritoneum that suspend the diaphragm's liver are the right and left coronary ligaments. To produce an effective and reliable product, the drug must have a fine particle size and a large surface area. The tablet coating takes place inside a perforated rotating drum in a controlled atmosphere. Tablets are lifted and turned into the center of the drum from the sides. To make the tablet surface easier to swallow, every tablet surface is exposed to an even amount of deposited/sprayed coating. The purpose of the present investigation is to formulate a tablet of Metadoxine, which improves cognitive impairment and the main psychological symptoms due to occasional or prolonged alcohol abuse, such as aggressiveness, agitation, mood, and behavioral disturbances. The tablets were prepared using direct compression, dry granulation, and wet granulation method and a comparison of the same with an innovator’s product. Keywords: Tablets, Metadoxine, Dry granulation, direct compression, wet granulation.