Existing reliability studies on K-out-of-N: G repairable retrial systems with mixed standbys mainly consider the case where the standby switching is completely reliable and the repair time follows an exponential distribution, and most of them directly analyze the system reliability indices based on probability theory. Given the existence of such phenomenon as standby switching failure in engineering, this paper proposes a novel reliability model of K-out-of-N: G repairable retrial system with switching failure, and performs statistical inference on the reliability to realize the modeling and evaluation of the system. The considered system consists of mixed standbys and a repairer with vacation. When an operating component fails, the warm standby one is switched to the operating one immediately, and the probability of switching failure during the switchover process is p. In the case where the repair time of failed components follows a general distribution, based on the supplementary variable method and recursive algorithm, the steps for calculating the system steady-state availability are presented. In the case of unknown parameters for repair time and retrial time, the Bayesian estimator of the steady-state availability under the squared error loss function and highest posterior density (HPD) confidence interval are obtained. In numerical simulation, the system reliability inference is realized by using the Monte Carlo (MC) method, and the validity of the inference method is analyzed.