The oil and gas industry is actively developing in Russia and every year the pace of construction of various enterprises in this field is increasing. Metal structures are often used to erect production facilities, as they are characterized by high reliability, industriality, durability and quick erection. The frames of production buildings designed for the oil refining and petrochemical industry must retain their load-bearing capacity throughout the entire specified period of operation, ensuring the safety of people, equipment, materials and products. Such production facilities with a higher level of responsibility have special requirements to ensure their safety in the event of an accident. The design of these buildings considers situations in which the damaged structures must retain their load-bearing capacity or their failure must be compensated by other elements of the frame to avoid complete destruction of the building.The issues concerning the mechanisms of collapse occurring in industrial buildings when they are subjected to special loads, as well as the identification of their most vulnerable nodes, are poorly studied. There are still no unified concepts and reliable engineering calculation methods based on them, which can provide protection against progressive collapse of buildings and guarantee their stability. Nowadays, the solution of the issue of resistance of industrial buildings to progressive collapse, according to the guidelines laid down in the legislative base, entails huge costs and a large overconsumption of materials, which causes disputes about the correctness of the approach laid down in the regulatory framework and requires research to find new optimal solutions to strengthen structures.This paper studies the resistance to progressive collapse of steel frames of single-storey industrial buildings and evaluates the effectiveness of measures to improve the avalanche collapse resistance of such buildings.In the study the frames of single-span and multi-span industrial buildings are examined for their stability under special impacts, various cases of exclusion from the work of the building structures are analyzed and the most efficient measures to improve the stability of such buildings are proposed.