Laser Direct Energy Deposition (LDED) is a highly precise additive manufacturing technique that enables the creation and repair of complex metal components by melting and depositing metal powders. This study comprehensively evaluates Ti-6Al4V alloy within the LDED framework, highlighting its performance relative to other metals such as stainless steel, Inconel, and aluminum alloys. Ti-6Al-4V, a titanium-based alloy known for its exceptional strength-to-weight ratio, fatigue resistance, and corrosion resistance, is scrutinized for its advantages and limitations in the LDED process. The research includes a detailed comparison of mechanical properties, thermal behavior, and cost-effectiveness of Ti-6Al-4V against other common LDED metals. Additionally, the study explores the impact of powder metallurgy techniques on the deposition quality and performance of Ti-6Al-4V, focusing on aspects such as powder production methods, particle size distribution, and alloying effects. Real-world applications and case studies from industries including aerospace, automotive, and medical engineering are examined to illustrate the practical advantages of Ti-6Al-4V. The paper concludes by identifying key challenges and opportunities associated with Ti-6Al-4V in LDED and offering recommendations for future research and practical applications. This comprehensive evaluation aims to enhance understanding of Ti-6Al-4V's role in LDED and guide its optimized use in advanced manufacturing contexts