In this study, the erosion characteristics of eutectic high entropy alloy under the liquid–solid two-phase flow is investigated by a coupled numerical-experimental method, in order to reveal the intrinsic relationship between microscopic erosion mechanism (experimental test) and the related particle-fluid-surface interaction (CFD modelling). Furthermore, instead of the common relation between average erosion rate and mainstream flow velocity, the relationship between local erosion distribution and local particulate flow characteristics is clarified. The erosion rate and erosion pattern match well between the experiment and simulation. The results demonstrate that NiCoCrFeNb0.45 exhibits superior anti-erosion performance when compared to other widely used equipment metals. The erosion profile agrees well with the shape of surface velocity distribution, indicating a close relationship between surface erosion behaviour and flow characteristics. In particular, the erosion pattern at a normal angle appears as a symmetric ring due to the flow stagnation phenomenon, with slight erosion damage in the centre area and severe erosion in the surrounding, whereas the erosion profile at an oblique angle displays an elliptic shape, with severe erosion damage in centre. Notably, the primary erosion mechanism varies dramatically in different surface regions, induced by the various impact velocities and angles associated with the corresponding changes in the flow field. This study provides a deeper understanding of erosion behaviour in terms of the interrelationship among the material mechanical properties, particulate flow field and particle-surface impingement behaviour.