Scour erosion around monopile foundations significantly impacts the structural integrity and operational performance of offshore wind turbines (OWTs). To deal with this problem, this paper proposes an innovative unsupervised data-driven methodology to detect foundation scour in OWTs. The proposed method employs acceleration data collected from the tower. A numerical model of the NERL 5 MW OWT installed in medium-dense sand is developed using OpenFAST software. The study employs the novelty detection method, where only data obtained from the healthy conditions are used for training and establishing a base model. In addition, the influence of operational conditions, e.g. different wind and wave parameters is also evaluated. The process consists of three steps: (a) data pre-processing to extract time domain features and isolate environmental variations, (b) training an unsupervised anomaly detection algorithm by employing the extracted features and (c) conducting real-time anomaly detection to assess the scour damage. The study results highlight the robustness and efficiency of the proposed method in detecting scour damage around monopiles under different environmental conditions. Keywords: Monopile, scour, unsupervised, Machine learning, damage detection, SHM.