Integrated Analysis Method Research Articles

Оценка мультипликативного влияния инвестиционных проектов Дальневосточного федерального округа на социально-экономическое развитие территорий

Approximately two thousand investment projects, which have already been financed at a cost of about 700 billion roubles, are being implemented in the Far Eastern Federal District. The effects from the implementation of these projects include the commissioning of about 270 enterprises and creation of over 40 thousand jobs. The paper aims to develop and test tools for estimating the multiplier effect of investment projects on the dynamics of regional development indicators. The integral analysis method was used to aggregate various multi-dimensional characteristics of selected projects into one synthetic indicator. As a result, a generalised ranking of investment projects was compiled to assess their combined contribution to regional development. The top-3 projects are: 1) Inaglinsky mining and processing plant (has the greatest economic effect estimated by the expected gross regional product increment of 252 billion roubles); 2) Vostochny Cosmodrome (is expected to create 4,000 new jobs); 3) Sakhalin GRES-2 (has a commercial effect estimated by the expected inflow of private investment in the amount of 432 billion roubles). A detailed study of Far Eastern investment projects in the coordinate space “regional efficiency — regional socio-economic development” allowed us to quantify their multiplicative contribution to socio-economic development of the regions. According to the ranking of investment projects in the Far Eastern Federal District, the largest projects, expected to show high quantitative results, have a multidirectional impact on the socio-economic indicators of the regions of operation. The research results can be used to develop national and regional support programmes for major investment projects to attract additional funding, establish a system of measures for maintaining a favourable investment climate in the region, as well as to create the necessary infrastructure.

Neurophysiological diagnosis and cerebroprotection in the case of brain injuries of medium severity in the remote period in soldiers of the joint forces operation (JFO)

Introduction. The problem of brain injury is important in the structure of general disability and mortality. Currently, highly effective methods of its treatment have been developed, the basis of which is aimed at reducing hypoxia of the brain structures, stimulating redox processes, and strengthening the utilization of oxygen and glucose. Since the severity of brain injuries is accompanied by cognitive and mental disorders, therefore, drugs to restore these functions in victims are of crucial importance. One of these neuroprotectors is citicoline, which is used in the case of lesions of the central nervous system of traumatic and vascular origin. The aim of the study. On the basis of observation of soldiers of the JFO, using modern methods of neurophysiological diagnostics, to study the peculiarities of changes in the electrical activity of the brain and to evaluate the type of reaction of the central nervous system to the effect of the drug citicoline in the case of a battle of medium severity in the remote period. Methodology and Methods. An analysis of the results of an electroencephalographic study of 31 soldiers of the JFO between the ages of 20 and 55 years with a brain injury of medium severity in the remote period. Using the method of integral quantitative analysis of the entire EEG pattern, coefficients were determined that reflected the ratio of spectral powers of all EEG bands, and changes in the coherence of EEG activity in all areas of both hemispheres of the brain were evaluated. Brain reactivity was assessed by changes in spectral power, integral coefficients in response to the administration of citicoline, the adequacy of its dose and the need for its correction. Results and Discussion. In soldiers of the JFO with a brain injury of medium severity in the remote period, the asymmetry of EEG activity was combined with changes in interhemispheric coherence indicators. Desynchronization of EEG activity was more pronounced in the central areas of the cortex. In response to the administration of citicoline, we received the following variants of brain reactivity: strengthening of the disorganization of EEG patterns, a conditionally favorable reaction of brain reactivity, a hyporeactive reaction, which was characterized by a decrease in disorganization of EEG patterns, and a favorable reaction of brain reactivity with the activation of normal EEG pattern rhythms. Conclusions. Choosing the right dose of a neuroprotector is a crucial moment for restoring the function of neurons and normalizing cortical-subcortical connections in the case of craniocerebral trauma of medium severity (cerebral contusions). For the normalization of EEG rhythms and cortical-subcortical connections, a daily dose of 1000 mg of citicoline was found to be the most optimal.

OPTIMIZATION OF THE TECHNOLOGICAL PARAMETERS OF THE HEAT RECOVERY SYSTEM OF A BOILER PLANT WITH THE AIR PROTECTION METHOD OF GAS WATER TRACTS

The results of a study of the efficiency and optimization of technological parameters of the heat recovery system of a boiler plant, in which the method of mixing part of the heated air into the flue gases after the heat recovery unit, is implemented. The essence of the air method is to increase the temperature and decrease the relative humidity of the resulting mixture, which reduces the amount of condensate on the walls of the exhaust ducts. A gas-consuming boiler plant with a heat recovery system for heating heat supply water is considered. To optimize the technological parameters of the system in the implementation of this method, a complex technique based on exergy analysis was used. The technique combines structural-variant methods and balance integral methods of exergy analysis. This allows you to determine the exergy, heat engineering and technological characteristics that are included in the criteria for evaluating the efficiency of heat recovery systems. Due to the small number of parameters required for the calculation, and the simplicity of the calculation and analytical methods for obtaining exergy characteristics, the technique is convenient for research. The accuracy of the results obtained is 0.3-0.5%. A block diagram of a boiler plant with a heat recovery system in the implementation of the mixing method is given. In the block diagram, input and output excretory flows between individual elements are identified. The criteria for evaluating the efficiency of heat recovery and the main technological optimization parameters have been selected. Based on the general system of exergy, thermal and material balance equations in accordance with the structural scheme, an exergy balance equation was compiled, from which exergy losses and heat-exergy efficiency criteria were determined. The optimal values in the heat exchanger heat output and the amount of mixed air, which correspond to the high efficiency of the system, are determined.

ЕКСЕРГЕТИЧНІ ДОСЛІДЖЕННЯ МЕТОДУ БАЙПАСУВАННЯ ДЛЯ ЗАХИСТУ ГАЗОВІДВІДНИХ ТРАКТІВ КОТЕЛЬНИХ УСТАНОВОК

The results of a study of the exergy efficiency of the method of flue gas bypassing, which ensures the prevention of condensate formation in the gas exhaust ducts of boiler plants, are presented. The block diagram of a heat recovery system with gas bypassing and the corresponding balance exergy equation are considered. The study was carried out using a complex methodology, including structural-variant and integral balance methods of exergy analysis. According to the results of the study, it was found that with an increase in the amount of bypassed flue gases, exergy losses decrease, and the values of the heat exergy criterion increase due to a decrease in the heat output of the heat recovery plant.

ANALYSIS OF EXERGY LOSSES IN HEAT RECOVERY SYSTEMS OF BOILER PLANTS WHEN IMPLEMENTING THE BYPASS METHOD TO PROTECT CHIMNEYS

The results of the analysis of exergy losses in the heat recovery systems of boiler plants during the implementation of one of the thermal methods of anticorrosion protection of gas exhaust ducts - the bypass method - are presented. Gas-consuming boiler plants with a heat recovery system for heating heat supply water are considered. The choice of a complex technique for the analysis of exergy losses in a heat recovery system with gas bypass is substantiated. The technique includes structural-variant and integral balance methods of exergy analysis and is effective due to the small number of parameters required for the calculation, the simplicity of the calculation and analytical methods for obtaining exergy characteristics, and the high accuracy of the results obtained. The principal and structural diagram of the heat recovery system in the implementation of the bypass method is given. In the block diagram, the input and output exergy flows between the individual elements of the heat recovery system are identified. According to the block diagram, an exergy balance equation was compiled, on the basis of which the exergy losses and the heat exergy efficiency criterion were determined. The exergy characteristics of the heat recovery system are given with an increase in the amount of bypassed gases and different values of the heat load of the heat recovery system. It is shown that the nature and extent of the impact of these parameters depend on the specified load. It has been established that an increase in the amount of bypassed gases at all values of the heat load of the heat recovery system leads to a decrease in exergy losses and the heat power criterion. The value of the heat load of the heat recovery system is determined, at which its exergy efficiency in the implementation of the bypass method is the highest.

Integrating whole genome sequencing, methylation, gene expression, topologically associated domain information in regulatory mutation prediction: A study of follicular lymphoma

A major challenge in human genetics is of the analysis of the interplay between genetic and epigenetic factors in a multifactorial disease like cancer. Here, a novel methodology is proposed to investigate genome-wide regulatory mechanisms in cancer, as studied with the example of follicular Lymphoma (FL). In a first phase, a new machine-learning method is designed to identify Differentially Methylated Regions (DMRs) by computing six attributes. In a second phase, an integrative data analysis method is developed to study regulatory mutations in FL, by considering differential methylation information together with DNA sequence variation, differential gene expression, 3D organization of genome (e.g., topologically associated domains), and enriched biological pathways. Resulting mutation block-gene pairs are further ranked to find out the significant ones. By this approach, BCL2 and BCL6 were identified as top-ranking FL-related genes with several mutation blocks and DMRs acting on their regulatory regions. Two additional genes, CDCA4 and CTSO, were also found in top rank with significant DNA sequence variation and differential methylation in neighboring areas, pointing towards their potential use as biomarkers for FL. This work combines both genomic and epigenomic information to investigate genome-wide gene regulatory mechanisms in cancer and contribute to devising novel treatment strategies.

Electrochemical Mineralization Kinetics of Metformin

Present work analyzes the kinetic study of mineralization during electro-oxidation on Ti/DSA (Ta2O5-Ir2O5) and combined electro-oxidation and electro-coagulation on stainless steel anode of an antidiabetic drug metformin hydrochloride (MET-HCl) in synthetic wastewater over a specific charge. Four different reaction orders (0.5, 1, 1.5 and 2) were tested using the integral analysis method by plotting TOC concentration terms over specific charges to determine the exact rate kinetics for the mineralization. The effect of applied current density was evaluated at 50 ppm of sodium sulphate as supporting electrolyte, and the effect of supporting electrolyte concentration was also assessed at a current density of 0.93 mA/cm2 in 50 ppm MET-HCl solution. As a result of (i) electro-oxidation experiments on MET-HCl, carried out on Ti/DSA anode, and (ii) combined electro-oxidation and electro-coagulation experiments carried out on stainless steel anode, based on the R-squared value of the mineralization curves, the first-order reaction rate was proposed.

Thermal-structural-optical integrated analysis method based on the complete equations of rigid body motion

Thermal-structural-optical integrated analysis method based on the complete equations of rigid body motion

Wavefront aberration sensitivity and integrated analysis method for spaceborne camera

Wavefront aberration sensitivity and integrated analysis method for spaceborne camera

Assessing the level of competitiveness of the insurance sector during economic crises: The example of Ukraine

In the context of the crisis in Ukraine, it is important to increase the competitiveness of the insurance sector as a measure of its stability and dynamism under various scenarios of economic development. The purpose of this paper is to assess the competitiveness of the insurance sector and determine the impact on its level of factors caused by economic crises. Using the method of integrated analysis, the index of competitiveness of the insurance industry is built, which considers the number of businesses, employment, sales, capital investment in the industry, insurance sector performance, share of profitable enterprises, and profitability of the insurance sector in Ukraine for 2012–2020. The results showed that the impact of the 2014–2015 crisis due to endogenous factors, namely political instability in the country and the devaluation of the hryvnia, led to a significant reduction in the competitiveness index of the insurance sector. At the same time, during the pandemic, the insurance sector is stabilized, as evidenced by the growth of sales and the share of profitable enterprises, as well as increasing profitability of insurance activities. The competitiveness index did not change significantly during the pandemic. To analyze the dependence of the integrated indicator of the competitiveness of the insurance sector on economic fluctuations during the crisis, regression equations are constructed. It is proved that the greatest impact on the competitiveness index of the insurance sector in times of crisis is exerted by changes in employment and the amount of capital investment.

Testing the integral suspension pressure method for soil particle size analysis across a range of soil organic matter contents

Testing the integral suspension pressure method for soil particle size analysis across a range of soil organic matter contents

Fluid-Structure Interaction Analysis of Aircraft Hydraulic Pipe with Complex Constraints Based on Discrete Time Transfer Matrix Method

Fluid-structure interaction (FSI) is prevalent in aircraft hydraulic pipes due to high-pressure fluid pulsation, complex pipe path routing and boundary constraints, which pose a serious threat to the safety and reliability of the aircraft hydraulic system. This paper focuses on the FSI response of aircraft hydraulic pipes with complex constraints. A comprehensive fourteen-equation model for describing the FSI of pipe conveying fluid with wide pressure and Reynolds number range is proposed. The excitation models and complex boundary constraints of liquid-filled pipes are established. Moreover, based on the transfer matrix method (TMM), combined with the time discreteness and analytical integral method, a discrete time transfer matrix method (DTTMM) for solving the FSI fourteen-equation model in time domain is presented. Then, the numerical solution and experiment of an ARJ21-700 aircraft hydraulic pipe with complex constraints is carried out with four working conditions. The obtained results verify the correctness of the proposed model and solution method, and reveal the universal laws of the FSI response about aircraft hydraulic pipes, which can also provide theoretical and experimental references for modeling, solutions and verification in the FSI analysis of pipe conveying fluid.

Improving membrane filtration performance through time series analysis

For ultrafiltration, and membrane filtration more generally, the quantitative determination of the modes of fouling remains a subject of great interest. Herein an integral method for determining the modes from a time series of volumetric flux Jleft(tright) is given and illustrated with previously published filtration data of bergamot juice (Ruby-Figueroa et al (J Membr Sci 524:108-116, 2017)). The integral method of fouling analysis has the potential to become the cornerstone of a robust empirical process. In addition to determining, in a clear-cut manner, the point at which there is a switch from one mode to another, the robust methodology yields characteristic Jleft(tright) equation for each mode that are an excellent fit to the data. The emphasis is upon the creation of a robust methodology which is best viewed as being a semi-empirical method that is indicative of the modes of fouling. For the example chosen, the initial 4 L/m2 generates some pore blocking after which the main mode of fouling is cake build-up. The variation of overall resistance with time is also informative and analysis of this series was used to check the result for the initial phase of fouling as determined from the time series of volumetric flux. A comparison against the ARIMA (Autoregressive integrated moving average) method, which has never been previously undertaken, is given herein. The integral method of fouling analysis was found to be superior, in part because of the quality of fit to the data and in part because it enables one to establish whether the initial fouling is different in character from the subsequent fouling. Having this information can improve membrane selection and overall membrane filtration performance.

Deactivation kinetics of γ-Al2O3 catalyst in methanol dehydration to dimethyl ether

The kinetics of deactivation of γ-alumina catalyst in dehydration of methanol to dimethyl ether (DME) was studied using integral method of analysis. A power-law rate expression was used for dehydration reaction and an independent kinetics for catalyst deactivation. Catalytic test runs were performed in a fixed-bed integral reactor in the temperature range of 250–300 °C under kinetically controlled reaction conditions. A second-order independent deactivation kinetics was found to fit experimental conversion-time data accurately. The activation energies of the main reaction and catalyst deactivation were obtained as 121 and −85 kJ/mol, respectively. The apparent negative value of the latter was attributed to a predominant deactivation mechanism via exothermic reversible partial hydration of active γ-alumina phase to the less active boehmite. At higher reaction temperatures, however, this mechanism is ceased at the expense of irreversible sintering of alumina crystallites.

Clinician responses to cannabis use during pregnancy and lactation: a systematic review and integrative mixed-methods research synthesis.

Perinatal cannabis use is increasing, and clinician counselling is an important aspect of reducing the potential harm of cannabis use during pregnancy and lactation. To understand current counselling practices, we conducted a systematic review and integrative mixed-methods synthesis to determine "how do perinatal clinicians respond to pregnant and lactating patients who use cannabis?" We searched 6 databases up until 2021-05-31. Eligible studies described the attitudes, perceptions, or beliefs of perinatal clinician about cannabis use during pregnancy or lactation. Eligible clinicians were those whose practice particularly focusses on pregnant and postpartum patients. The search was not limited by study design, geography, or year. We used a convergent integrative analysis method to extract relevant findings for inductive analysis. Thirteen studies were included; describing perspectives of 1,366 clinicians in 4 countries. We found no unified approach to screening and counselling. Clinicians often cited insufficient evidence around the effects of perinatal cannabis use and lacked confidence in counselling about use. At times, this meant clinicians did not address cannabis use with patients. Most counselled for cessation and there was little recognition of the varied reasons that patients might use cannabis, and an over-reliance on counselling focussed on the legal implications of use. Current approaches to responding to cannabis use might result in inadequate counselling. Counselling may be improved through increased education and training, which would facilitate conversations to mitigate the potential harm of perinatal cannabis use while recognizing the benefits patients perceive.

Industry Solution Adaptability

The spectrum of changes that enterprises need to deal with varies from simple continuous adjustments of the product portfolio in response to evolving customer preferences, to complete overhauls of the business and operating model in response to disruptive trends. Many research fields and practitioner disciplines have produced analysis and engineering approaches that can help enterprises to assess and prepare for the impact of changes from this spectrum. However, they have partial scopes and consequently limited integration. By selecting, slightly extending and integrating existing approaches, this paper introduces a ‘simple enough’ integrated solution model and a ‘simple enough’ integrated analysis and engineering method that covers the full spectrum of changes.Our focus is the large, complex enterprise that operates in a specific industry and performs information processing at scale. The research is intended to provide methodical support to practitioners with a responsibility for shaping solutions. Our proposal is the result of initial experiences in practice that instilled the research theme, application in a large-scale industry project, focused collaborative research that joined researchers and academia, and ongoing applications and experiences in practice. The solution model and the analysis and engineering method that we propose support three types of adaptability: a) foundational adaptability produces full new business model and operating model parts, b) transitional adaptability extends the current business model and operating model and adds additional configurability, and c) routine adaptability is managed within the configurability of individual operating model components that need to be designed with sufficient bandwidth. A business configuration center is proposed as a key constituent that manages the differences in underlying technology, and that allows to perform integrated, technology agnostic administration of an industry solution.

Chemical Plant Explosion Accident (Cause) Analysis Using AcciMap and FRAM

To prevent accidents in chemical plants, it is important to identify the root cause of the accident and suggest countermeasures. When accident factors are known, eliminating the cause of the accident can increase its prevention. The number of factors, including social factors, in addition to human factors, is increasing. When analyzing the cause of an accident when it is complex, advanced, and the connection between processes is high, there is a growing need to approach it with an integrated system analysis method related to the organization, along with a sequential approach to determine the direct cause of the accident. Several countries have introduced and applied techniques for integrated analysis of accidents from a systematic viewpoint, such as AcciMap and the functional resonance accident model (FRAM) that were developed around 2000. However, it remains difficult to find cases or research results applied in Korea. In this study, accidents in Korean chemical factories are analyzed using systematic accident analysis techniques, and a plan to utilize systematic analysis techniques for future accident investigations is developed.

Integrative analysis methods for spatial transcriptomics.

Integrative analysis methods for spatial transcriptomics.

Longitudinal integral response deformation method for the seismic analysis of a tunnel structure

Longitudinal integral response deformation method for the seismic analysis of a tunnel structure

A Recursive Legendre Polynomial Analytical Integral Method for the Fast and Efficient Modelling Guided Wave Propagation in Rectangular Section Bars of Orthotropic Materials

Ultrasonic guided waves are widely used in non-destructive testing (NDT), and complete guided wave dispersion, including propagating and evanescent modes in a given waveguide, is essential for NDT. Compared with an infinite plate, the finite lateral width of a rectangular bar introduces a greater density of modes, and the dispersion solutions become more complicated. In this study, a recursive Legendre polynomial analytical integral (RLPAI) method is presented to calculate the dispersion behaviours of guided waves in rectangular bars of orthotropic materials. The existing polynomial method involves a large number of numerical integration steps, and it is often computationally costly to compute these integrals. The presented RLPAI method uses analytical integration instead of numerical integration, thus leading to a significant improvement in the computational speed. The results are compared with those published previously to validate our method, and the computational efficiency is discussed. The full three-dimensional dispersion curves are plotted. The dispersion characteristics of propagating and evanescent waves are investigated in various rectangular bars. The influences of different width-to-thickness ratios on the dispersion curves of four types of low-order modes for a rectangular bar of an orthotropic composite are illustrated.