Fasting Method Research Articles

From weight loss to cancer treatment: Fasting as an adjuvant anticancer therapy

The number of studies that have been conducted on the possible benefits of different types of fasting or calorie restriction on cancer therapy, including the likelihood that these treatments lessen side effects, has been limited. However, the results are nevertheless promising. Chemotherapy’s adverse effects have led to a quest for options that reduce reliance on it. The susceptibility of tumorous cells to specific metabolites and nutrient deficiency is increasingly recognized as a key characteristic of the disease. This review delves into the data on various fasting methods and calorie restriction in rodents and humans, with a focus on biological adaptations that could potentially lower cancer risk or enhance cancer treatment results. We also emphasize recent scientific developments regarding the use of prolonged fasting and fasting-mimicking diets as a possible additional treatment for patients receiving immunotherapy or other treatments. This approach shows promise in enhancing treatment effectiveness, preventing resistance, and minimizing side effects. This study proposes that combining fasting and calorie restriction with chemotherapy, immunotherapy, or other therapies might be a potential technique to improve treatment efficacy, avoid resistance, and reduce adverse effects.

Effects of Intermittent Fasting on Weight Loss and Metabolic Health

Introduction and Purpose: Intermittent fasting (IF) has become a popular strategy for combating obesity and improving metabolic health. This dietary regimen alternates between periods of fasting and eating, aiming to enhance cellular health and increase longevity. With obesity rates doubling globally since 1990 and metabolic diseases on the rise, IF offers a potential solution by promoting metabolic benefits and reducing obesity-related conditions. Material and Method: This review examines various IF methods, including alternate-day fasting, the 5:2 diet, and time-restricted eating. The analysis focuses on the impact of these fasting methods on body weight, insulin sensitivity, and lipid profiles, based on a compilation of studies that explore the physiological effects and health outcomes associated with IF. Results: IF has shown to be effective in reducing body weight and improving metabolic parameters. Studies indicate significant benefits in insulin sensitivity and lipid profiles, with some variations across different IF protocols. Physiological insights reveal that IF leads to a metabolic switch from glucose-based to ketone-based energy, which plays a critical role in its effectiveness. Conclusions: Intermittent fasting appears to be a viable alternative to continuous calorie restriction for weight loss and metabolic enhancement. It not only aids in weight management but also offers additional health benefits such as improved insulin sensitivity and better lipid profiles. However, more long-term studies are needed to fully understand its benefits and potential risks. Future research should focus on optimizing fasting protocols and exploring their long-term effects on health and disease.

STUDY TO COMPARE FASTING GASTRIC VOLUME USING ULTRASOUND IN DIABETIC AND NON DIABETIC PATIENTS POSTED FOR ELECTIVE SURGERIES

Objective: To study the comparison of fasting gastric volume using ultrasound in diabetic and nondiabetic patients in elective surgeries. To compare the incidence of delayed gastric emptying in diabetic and nondiabetic after standard fasting guidelines Material and Methods: After institutional ethical committee approval, CTRI registration and patient consent, prospective study was conducted in 30 diabetic and 30 non-diabetic patients aged 30-60years of American society of anesthesiologists- physical status I-III having similar fasting intervals. Pre operatively, quantitative assessments of gastric antrum in supine and right lateral decubitus (RLD) positions were performed using curvilinear probe in accordance to standard gastric scanning. USG grade, cross-sectional area (CSA) of the antrum and gastric volume were calculated. The gastric antrum was classified as Grade 0, 1 or 2, signifying empty antrum, fluid in RLD position only and antral fluid in both supine and RLD positions, respectively. Results:The CSA of 2.35 ± 1.07 cm2 and 3.51 ± 1.4 cm2 in diabetic were significantly higher (P = 0.001) than 1.37 ± 0.32 cm2 and 2.19 ± 1.15 cm2 of control, in supine and RLD positions, respectively. GV was 3.85± 20.06 ml in control group and 6.5±23.51 ml in diabetic group. Conclusion: Diabetic patients have higher gastric antral cross-sectional area and gastric volumes as observed by gastric ultrasound than the non-diabetic patients. Reference - 1. Robinson M, Davidson A. Aspiration under anaesthesia: Risk assessment and decision-making. Contin Edu Anaesth Crit Care Pain. 201314:171–5. 2.Perlas A, Chan VW, Lupu CM, Mitsakakis N, Hanbidge A. Ultrasound assessment of gastric content and volume. Anesthesiology. 2009111:82–9. 3. Smith I, Kranke P, Murat I, Smith A, OSullivan G, Soreide E, et al. Perioperative fasting in adults and children: Guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 201128:556–69.

Effect of Ayambil (A Type of Jain Intermittent Fasting) on Plasma Glucose, Lipid Profile, Anthropometric and Psychological parameters: An Observational Study

The practice of voluntary abstinence from food and drink for 16 to 48 hours is known as intermittent fasting (IF). Jain Ayambil is, a type of intermittent fasting, where a special meal of boiled grains without spice, oil, milk, ghee, sugar, curd, fruits, or raw vegetables is taken once during the daytime. The aim of the study was to find out safety and its effect on plasma glucose, lipid profile, anthropometric and psychological parameters. We are reporting first ever scientific study on effect of Aymabil intermittent fasting on health parameters. The present study was carried out on 52 volunteers who did 9 days Ayambil fasting. Physical, and psychological assessment were done on the pre-fasting day (day 0), 4th day, and 9th day whereas biochemical examinations were carried out on pre-fasting (day 0) and 9th day of Ayambil fasting. Out of the total 52 participants (mean age of 52.77 ± 13.51 years), there were 28 (53.85%) females (51.54 ± 12.94) and 24 (46.15%) males (54.21 ± 14.30). A statistically significant reduction was observed for fasting blood glucose (p=0.002), HbA1c (p=0.002), body weight (p=0.001), BMI (p=0.001), diastolic BP (p=0.005), serum creatinine (p= 0.036), and a positive correlation was noted for Hamilton Depression Rating Scale (HDRS) (p=0.001) noted during Ayambil fasting. However, there was no significant change in lipid profile. Our findings suggest that Ayambil fasting is beneficial to metabolic, psychological, and holistic health with no health-related hazards. It is a safe fasting method and exploration of more clinical studies on this can open newer futuristic directions as one of the therapeutic options for a variety of clinical situations.

Effects of the periodic fasting-mimicking diet on health, lifespan, and multiple diseases: a narrative review and clinical implications.

Dietary restriction and fasting have been recognized for their beneficial effects on health and lifespan and their potential application in managing chronic metabolic diseases. However, long-term adherence to strict dietary restrictions and prolonged fasting poses challenges for most individuals and may lead to unhealthy rebound eating habits, negatively affecting overall health. As a result, a periodic fasting-mimicking diet (PFMD), involving cycles of fasting for 2 or more days while ensuring basic nutritional needs are met within a restricted caloric intake, has gained widespread acceptance. Current research indicates that a PFMD can promote stem cell regeneration, suppress inflammation, extend the health span of rodents, and improve metabolic health, among other effects. In various disease populations such as patients with diabetes, cancer, multiple sclerosis, and Alzheimer's disease, a PFMD has shown efficacy in alleviating disease symptoms and improving relevant markers. After conducting an extensive analysis of available research on the PFMD, it is evident that its advantages and potential applications are comparable to other fasting methods. Consequently, it is proposed in this review that a PFMD has the potential to fully replace water-only or very-low-energy fasting regimens and holds promise for application across multiple diseases.

A recommendation system for selecting intermittent fasting method to improve health in type 2 diabetes

A recommendation system for selecting intermittent fasting method to improve health in type 2 diabetes

Protocol For Intervention Study In Reducing Elevated Blood Pressure Through Intermittent Fasting.

To chart out a protocol for conducting an intervention-based study to compare the efficacy of intermittent fasting intervention and usual diet in reducing elevated blood pressure among working adults. The quasi-experimental study with single-blinded parallel groups will comprise subjects from two civil departments. The intervention group will be required to conduct 2 days of fasting and 5 days of ad libitum diet in a week, while the control group will follow the usual healthy lifestyle. The largest sample size will be taken to achieve a power of 80% and an alpha value of 5%. Based on the 30% attrition rate, the total sample size needed in the study will be 140 participants, with 70 in each of the two arms. This study will use SPSS 24 for statistical analysis. The study describes a unique protocol of intermittent fasting mimicking the Muslim Sunnah of fasting among people with elevated blood pressure. The findings will contribute to decrease blood pressure among those with elevated blood pressure. If proven to be effective, the intermittent fasting method would be useful for developing an effective programme to prevent elevated blood pressure among adults. The protocol will contribute to efforts to find whether or not intermittent fasting can improve elevated blood pressure as well as body weight, body mass index, waist circumference and nutrition status among adults. The study was registered with clinicaltrials.gov (NCT04953650).

Effects of Banxia Xiexin Decoction on apoptosis of interstitial cells of Cajal via regulation of MiR-451-5p: An in vivo and in vitro study

Ethnopharmacological relevanceBanxia Xiexin Decoction (BXD) is a traditional Chinese medical formula applied to gastrointestinal (GI) motility disorders. Previous studies showed that miR-451-5p was down-regulated in rats with GI motility disorders induced by gastric electrical dysrhythmia. Interstitial cells of Cajal (ICCs) are pacemakers for GI motility, while loss of ICCs is responsible for GI motility disturbance. Thus, the underlying interaction mechanisms for BXD regulating ICCs apoptosis via miR-451-5p remain to be explored. Aim of the studyIn this work, the main objectives were to examine the efficacy of BXD on ICCs via miR-451-5p both in GI motility disorders rats model and in vitro, as well as the potential contributions of SCF/c-kit signaling. Materials and methodsRats with gastric electrical dysrhythmia were established in male SD rats by using a single-day diet and a double fasting method (drinking diluted hydrochloric acid water during the period) for 4 weeks. The gastric slow wave (GSW) recording, RT-qPCR, and western blot were performed to examine the effects of BXD on ICCs apoptosis in rats with GED and miR-451-5p expression. In vitro assays included CCK-8, flow cytometry analysis, RT-qPCR, and western blot were applied to investigate the potential molecular mechanism of BXD on ICCs apoptosis via miR-451-5p. ResultsBXD promoted gastric motility, reduced ICCs apoptosis, and elevated miR-451-5p in GED rats. In addition, miR-451-5p was significantly up-regulated in ICCs after BXD treatment compared with that in ICCs with miR-451-5p inhibitor transfection. Meanwhile, high miR-451-5p expression with either BXD treatment or miRNA mimics enhanced ICCs proliferation and inhibit apoptosis. Moreover, overexpression of miR-451-5p can reverse G0/G1 arrest in ICCs by BXD treatment. Further, SCF and c-kit protein levels were detected to demonstrate that modulation of miR-451-5p by BXD treatment was involved in this signaling. ConclusionsThrough this study, we demonstrated that BXD could promote ICCs proliferation and inhibit apoptosis via miR-451-5p and may involve the modulations of SCF/c-kit signaling, thus suggesting a new therapy basis for GI motility dysfunction from the perspective of modulation of ICCs apoptosis by targeting miR-451-5p.

Effects of non-fasting molting on performance, oxidative stress, intestinal morphology, and liver health of laying hens.

Animal welfare concerns in laying-hen production facilities have necessitated research on alternative strategies for improving egg production and hen health. At present, most laying-hen facilities in China use the fasting method, but with international emphasis on animal welfare, scholars have begun to find ways to improve production efficiency while ensuring animal welfare standards are adhered to. Therefore, this study investigated the effects of non-fasting molting on production performance, oxidative stress, intestinal morphology, and liver health of laying hens. A total of 180 healthy 90-week-old Dawu Jinfeng laying hens with similar body weights and laying rates (76 ± 2%) were randomly divided into three groups, with five replicates per group and 12 hens per replicate. The hens in the experimental group (NF) were molted using the non-fasting method, the negative control group (C) was not treated with centralized molting, and the positive control group (F) was molted using the fasting method. The results showed that: (1) During the molting period, the laying rate in the NF group (10.58%) decreased and was significantly lower than that in the other two groups (P < 0.05). During the secondary laying peak period, the laying rate in the NF group was highest (89.71%); significantly higher than that in the C group (P < 0.05). (2) During the molting period, compared to the C group, the NF group showed a significant decrease and increase in the total antioxidant capacity (T-AOC) and superoxide dismutase (T-SOD) activity, respectively (P < 0.05). During the secondary laying peak period, the T-SOD activity of the NF group was significantly lower than that of the C group (P < 0.05). (3) During the molting period, the villus height (VH) and the ratios of VH to crypt depth (V/C) of the duodenum, jejunum, and ileum in the NF group were significantly lower than those in the C group (P < 0.05). At the secondary laying peak period, the jejunum V/C was significantly higher than that in the C group (P < 0.05), whereas in the duodenum and ileum it increased but not significantly (P > 0.05). (4) During the molting period, serum glutathione transaminase (AST) and glutathione alanine transaminase (ALT) activities were significantly higher (P < 0.05), and very low-density lipoprotein (VLDL) content and liver weight were significantly lower (P < 0.05) in the non-fasted and fasted groups. However, there was a low degree of liver injury (cell boundary still visible) in the NF group. At the secondary laying peak period, there was no significant difference (P > 0.05) in the indices among the three groups and the liver returned to normal. In summary, non-fasting molting can improve the production performance of laying hens in the later stages, ensure the welfare and health of animals, and provide a theoretical basis for the efficient production of laying hens.

The feasibility of implementing food-based dietary guidelines and food graphics in Ethiopia

This study aimed to test the acceptability, cultural appropriateness, consumers' understanding, and practicality of the Ethiopian food-based dietary guideline's messages, tips, and food graphics. A qualitative study design was applied with focus group discussions and key informant interviews. Four different participant groups were included: 40 consumers, 15 high-level nutrition experts, 30 frontline community health extension workers (HEWs), and 15 agriculture extension workers (AEWs) to incorporate different stakeholder perspectives. Data collection was conducted using 7 focus group discussions (FGDs) and 30 key informant interviews (KIIs). Collected data were coded and analyzed using QSR International NVivo V.11 software. Most of the study participants were highly interested in implementing the dietary guidelines once these guidelines are officially released. Based on the participants' views, most of the messages align with the current nutrition education materials implemented in the country except the messages about physical activity and alcohol intake. However, participants suggested defining technical terms such as ultra-processing, whole grain, safe and balanced diet in simpler terms for a better understanding. Practicality, affordability, availability, and access to the market were the major barriers reported for adherence to the guidelines. To be more inclusive of cultural and religious beliefs, findings show that the guideline should address fasting and traditional cooking methods. In conclusion, the dietary guidelines were well received by most stakeholders. They are thought to be feasible once feedback on wording, affordability, availability, and access is considered in the messages, tips, and graphic designs.

PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases.&#x0D; Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol.&#x0D; Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol.&#x0D; Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p &gt; 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment.&#x0D; Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol.&#x0D; Keywords: intermittent fasting, SGOT, paracetamol

Alternate day fasting and time-restricted feeding may confer similar neuroprotective effects during aging in male rats.

Age associated neurodegenerative changes are acknowledged to play a causative role in a majority of neurological diseases that accompany aging in organisms. To alleviate the deteriorative effects of aging in the brain, we investigated the effects oftwo types of intermittent fasting (IF) methods: alternate day fasting (ADF) and time- restricted feeding (TRF) in young (3months) and old (24months) in male Wistar rats comparing the results with age matched controls. The evaluation of biomarkers of oxidative stress showed significant decline in the old (ADF and TRF) groups in addition to up regulation in antioxidant levels. It was observed that ADF and TRF methods helped reduce ROS accumulation in the mitochondria and increased the activity of the electron transport chain complexes especially C-I and III. Gene expression analysis of autophagy genes like beclin and LC3B showed upregulated expression in ADF and TRF group. Sirtuin1 expression too significantly increased during fasting in both young and old groups showing fasting induced protection from aging. Histological analysis of sections of cerebral cortex and CA1 area provide evidence that fasting protected neurons against degeneration with age. Our results prompt us to conclude that the efficacy of these fasting methods ADF and TRF are reliable anti- aging strategies with respect to dietary restriction interventions. Moreover, both these methods compete closely in conferring protection from oxidative stress and inducing neuroprotective changes in brain of aged rats when compared to their young counterparts.

Discordance In Fasting And Postprandial Indices Of Glycemic Dysregulation In Individuals With Spinal Cord Injury

Fasting levels of glucose and insulin are routine clinical measures used to diagnose type-2 diabetes. However, individuals with spinal cord injury (SCI) often present with clinically normal fasting glucose but have impaired postprandial responses to a meal challenge. PURPOSE: We aimed to characterize the postprandial glycemic responses and assess the prevalence of glycemic dysregulation using fasting and postprandial indices in individuals with SCI. METHODS: Sixteen men with chronic SCI reported to the laboratory after an overnight fast to undergo either a 2-hour: oral glucose tolerance test (OGTT) using a 75-g (~300 kcal) glucose load (n = 8) or; a mixed meal tolerance test (MMTT, (1037 ± 148 kcal: 45% CHO, 37% fat, 18% PRO) (n = 8). Serial measurements of systemic glucose and insulin concentrations at baseline and in response to the OGTT/MMTT were converted into summary statistics: Insulin Resistance was estimated by the Homeostasis Model Assessment of Insulin Resistance (HOMA2-IR); whole body Insulin Sensitivity Index was estimated using methods described by Matsuda (ISIMatsuda). RESULTS: There were no differences between groups in age (p = 1.0), body mass index (p = 0.87), cardiorespiratory fitness (p = 0.26), fasting glucose (p = 0.53) or insulin (p = 0.19). In the MMTT group, 3 (38%) individuals were identified as prediabetic (fasting plasma glucose (FPG), 7.3 ± 0.9 mmol/L) and 0 individuals had impaired insulin resistance (HOMA2-IR, 1.05 ± 0.6). However, 5 (63%) individuals had impaired postprandial insulin sensitivity (ISIMatsuida, 2.2 ± 0.4). In the OGTT group, 2 (25%) individuals were prediabetic (FPG, 6.2 ± 0.2 mmol/L), 2 (25%) different individuals had impaired insulin resistance (HOMA2-IR, 3.2 ± 0.9), but 7 (88%) individuals had impaired postprandial insulin sensitivity (ISIMatsuida, 2.3 ± 0.9). CONCLUSIONS: In this small study, an OGTT identified more SCI participants with glucose dysregulation than MMTT. Postprandial measures of insulin sensitivity identified a greater proportion of SCI participants with impaired glycemic control and may have preferred utility in identifying individuals at high risk of diabetes. Future studies should compare and contrast the specificity and sensitivity of fasting and postprandial methods in this high-risk population.

Education of complementary and alternative medicine in adult education centers in Germany: aweb-based survey.

Adult education centers are an important part of health education worldwide. Our aim was to evaluate the courses offered by German adult education centers with regard to complementary medicine and nutrition. Asystematic web-based search was done for the websites of German adult education centers and courses were analyzed considering topics, scientific soundness, and qualification of instructors. Our search revealed 502 courses, 360 (71.7%) related to complementary and alternative medicine (CAM) and 176 courses on nutrition (35.1%). CAM courses most often presented methods with afocus on traditional Eastern medicine with yoga and similar mind-body practices (41.9%), traditional Chinese medicine (TCM; 13.3%), and ayurvedic medicine (11.4%). Content concerning nutrition mainly included controversial fasting methods like alkaline fasting, detox diets, and therapeutic fasting (43.8%), as well as Eastern traditional diets from TCM and ayurveda (21.7%). Most of the courses were given by non-medical practitioners (NMPs; 36.4%), while only very few physicians were engaged. There are substantial doubts on the scientific background of many courses offered for lay adult health education. Besides direct misinformation, many courses reinforce alternative and non-evidence-based notions in society. Adult education centers should reconsider the topics of their courses as well as the professional qualifications of the instructors.

Doppler and clinical characteristic of cephalgia in patients with arterial hypertension during intermittent fasting

There were examined 142 patients with recurrent headache (cephalgia) and arterial hypertension, a mean – 49.26±1.33 years, of whom 69 men, 73 women who used intermittent fasting (patients spent 24 hours without food, 1 time per week, four repetitions). The control group consisted of 32 people of comparable age without hypertension (n=32; mean age 51.0±1.99 years). The purpose of the study was to increase the effectiveness of diagnostic and therapeutic methods in patients with hypertension and headache by establishing the meaning and peculiarities of the influence of intermittent fasting on headaches, neck carotid and intracranial circulation. There were 51 (35.9%±4.03) patients aged 25-44 years’; 45-59 years – 42 (29.58%±3.83) patients; 60-75 years – 49 (34.51%±3.99) patients. It was found that the structural pathology of the main arteries of the head consisted mainly in the thickening of the intima-media from 0,8 to 1,4 mm in 62.7% at the age of 25-44 years; in 71,4% at the age of 45-59; in 51% at the age of 60-75 years. Local thickenings in the bifurcation zone from 1.5 mm without hemodynamically significant stenosis were found in 9.8% at the age of 24-44 years, in 28.6% at the age of 45-59 years and in 49% at the age of 60-75 years. Statistical differences in linear circulatory velocity between the control group and the group of patients were significant already at the age of 25-44 years, for peak systolic velocity in the internal carotid artery (78.03±4.67 vs. 61.0±2.54 in control, p&lt;0.05). At the age of 45-59 years, linear circulatory velocity affected all carotid and vertebral arteries, as in the group aged 60-75. The effect of intermittent fasting on aged hemodynamics consists mainly in changes of velocity of flow in arteries with better results in younger patients. Changes in the elastic-tonic characteristics of the main arteries of the head according to the index of resistance (index was 0.72±0.01 for common carotid artery and 0.63±0.01 after intermittent fasting in patients at the age of 25-44 years; 0.78±0.01 before and 0.67±0.01 after at the age of 60-75 years were revealed). The use of the intermittent fasting method caused mainly an increase in diastolic flow rates in the main arteries (with age dependences) and a decrease in systolic velocity in the age group 25-44 years. The pathophysiological interpretation of such changes is in the reducing the resistance, values of the main arteries of the head.

Hiperglikemia pada Pasien Diabetes Melitus Tipe 1 dan 2 yang Menjalani Puasa Ramadan : Laporan Kasus

Background: Ramadan fasting is an obligation for every Muslim, including Muslim patients who suffer from diabetes mellitus. The most common complication in diabetic patients when fasting is hypoglycemia, but in special conditions, hyperglycemia can also occur, and even emergency occurs in both type 1 and type 2 diabetes patients. Purpose: To know the hyperglycemia complications in type 1 and 2 diabetes mellitus in Ramadhan fasting Methods: Reported a case of inpatient diabetes mellitus 1 and 2 who underwent fasting during Ramadan and complications of hyperglycemia occurred in dr. Saiful Anwar Hospital (RSSA) Malang during the month of Ramadan Results: Both patients experienced hyperglycemia which was a response to an increase in response to hypoinsulinemia in type 1 diabetes and an increase in glycogenolysis in DM type 2. Conclusion: Hyperglycemia can occur in patients with type 1 and 2 DM who fast during the month of Ramadan

Siddha fasting in obese acute decompensated heart failure may improve hospital outcomes through empowerment and natural ketosis

BackgroundMorbid obesity (BMI > 35 kg/m2 with comorbid conditions) is present in 25 – 35% of acute decompensated heart failure (AHF) patients. Prevalence of HF increases with duration of morbid obesity from 30% at 15 years to over 90% at 30 years. There is a need to develop pragmatic therapies that address the unique physical and mental challenges faced by obese AHF patients. Siddha is 5,000 year old Tamil Medicine using yoga and mind-body methods towards higher consciousness. Hunger gratitude Experience (HUGE) is intuitive Siddha fasting method which may improve in-hospital AHF outcomes independent of weight reduction. Case summaryWe present 5 cases of morbidly obese patients with cardiorenal syndrome (CRS) that began intermittent fasting either during their AHF hospitalization or in the outpatient setting for refractory symptoms despite hospitalization. Initiation of fasting correlated with reduction of respiratory distress and edema as well as improvements in psychological wellbeing and functional capacity. DiscussionSiddha fasting mediates hemodynamic and anti-inflammatory effects through natural ketosis and psychological benefits through empowerment in AHF. Potential role of fasting in reducing myocardial workload, coronary steal, angina, volume overload, and CRS needs further study in cardiac patients.

Management application of feeding with different fasting methods in milkfish seeding (Chanos chanos)

Milkfish has a high market demand, the existence of consumption milkfish is influenced by the success of the nursery. This study aims to determine the effect of feeding different feeding methods on milkfish to milkfish. The research was carried out from September to October 2020 at the Hatchery and Aquaculture Technology Laboratory, Faculty of Agriculture, Malikussaleh University. The experimental research method used a non-factorial Completely Randomized Design (CRD) consisting of 4 treatments and 3 replications, namely A: Control (given daily feed), B: 1 day of fasting, 3 days of feeding, C: 2 days of fasting, 2 days of feeding feed, D: 3 days of fasting, 1 day of feed. The results showed that the feeding method of fasting was different with the best treatment found in treatment B, namely 1 day fasting, 3 days of feeding. Behavior, increased appetite, normal movement and normal metabolism, daily feed consumption of 1.23 grams, total feed consumption of 39.26 grams, length growth of 2.03 cm, weight growth of 3.06 grams, feed efficiency of 73.96%, Feed conversion was 1.35 and had a significant effect on survival, with treatment A having the highest survival, namely 87%.Keywords: Efficiency, Fasting, Feed, Growth, Milkfish

How Does Fasting Affect Cognition? An Updated Systematic Review (2013-2020).

The goal of this review was to provide an update on the literature examining how voluntary, temporary abstention from eating impacts cognitive function. We evaluated peer-reviewed articles published between August 2013 and January 2021 that assessed adults, included a measure of cognitive functioning with neutral stimuli, and compared individuals in a fasted state to individuals in a fed state (either within- or between-subject designs). Nineteen articles (21 studies) met inclusion criteria. Sample sizes, fasting methods, and tasks varied across studies. Review of studies indicated that fasting was associated with deficits in cognitive functioning; few studies indicated a benefit in cognitive functioning following a single voluntary fast. The heterogeneity and rarity of available studies limits the conclusions that can be drawn. Several crucial psychosocial and sociodemographic moderators remain unexplored. Recommendations for future work are discussed.

A influência do método estratégico jejum intermitente para o emagrecimento saudável: uma revisão

Baseado na elevada incidência de excesso de peso e obesidade em todo o mundo, dietas para emagrecimento são fortemente requisitadas pela população, a exemplo da dieta do jejum intermitente, que ganhou destaque ficando conhecida como uma “dieta da moda”. Dessa forma, objetivou-se realizar uma revisão na literatura sobre o jejum intermitente analisando seus possíveis benefícios e efeitos adversos. Para isso, foi conduzida uma busca bibliográfica nas bases de dados: PubMed, Google Acadêmico, MEDLINE e Periódicos CAPES. Foram incluídos nessa pesquisa apenas artigos que envolvessem seres humanos publicados em língua inglesa e portuguesa no período de 2007 a 2017. Ao final, foram encontrados 12 artigos de ensaios clínicos e/ou randomizados em humanos considerando 4 subclasses do método jejum intermitente. Todos os estudos analisados descrevem alterações nos parâmetros de composição corporal após intervenção em curto prazo. Novos estudos envolvendo seres humanos são necessários para avaliar eficácia, viabilidade e riscos à longo prazo.