Design Method Research Articles

Homogeneous B0 coil design method for open-access ultra-low field magnetic resonance imaging: A simulation study

A multimodal brain function measurement system integrating functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) is expected to be a tool that will provide new insights into neuroscience. To integrate fMRI and MEG, an ultra-low-field MRI (ULF-MRI) scanner that can generate a static magnetic field (B0) with an electromagnetic coil and turn off the B0 during MEG measurements is desirable. While electromagnetic B0 coil has the above advantages, it also has a trade-off between size and the broadness of the magnetic field homogeneity. In this study, we proposed a method for designing a B0 multi-stage circular coil arrangement that determines the number of coils required to maximize magnetic field homogeneity and minimize the total wiring length of the coils. The optimized multi-stage coil arrangement had an external shape of 600 mm in diameter and a maximum height of 600 mm, with an aperture of 600 mm in diameter and 300 mm in height. The magnetic field homogeneity was <100 ppm over a 210 mm diameter spherical volume (DSV). Compared to a previous two coil pairs arrangement with the same magnetic field homogeneity, the diameter was 1/1.9 times smaller, indicating that the newly designed B0 coil arrangement realized a smaller size and wider magnetic field homogeneity.

Multi-Objective Optimization Design of Dynamic Performance of Hydrofoil with Gurney Flap

The horizontal axis tidal turbine, as a crucial device for capturing tidal energy, has gained significant attention because it has better energy efficiency performance. Enhancing the performance of foils, a vital part of tidal turbine blades, can significantly improve tidal turbine performance. Among numerous methods to enhance the foil performance, the Gurney flap has gained significant attention due to its avoidance of complex structural design. Currently, there is limited research on optimizing the design of Gurney flaps while considering the dynamic performance of foils. In this study, the S809 foil with a blade cross-section was selected as the research subject, a multi-objective optimization design platform was created by integrating a multi-objective optimization algorithm with Computational Fluid Dy-namics (CFD) numerical simulation techniques. The objective of this platform is to enhance the dynamic performance of the hydrofoil by optimizing the geometric structure of the Gurney flap. The improvement of dynamic lift and the size of the dynamic stall hysteresis loop are used as objective variables in this study to evaluate the hydrofoil’s dynamic performance. The optimal Latin hypercube design method is used in the optimization process to choose sample locations, and the Kriging approximation model is used to determine the relationship between the design variables and the objective variables. Meanwhile, the Non-Dominated Sorting Genetic Algorithm-II (NSGA-II) is used to create a multi-objective optimization platform for solving the optimization problem, and the optimized results are validated using CFD. Comparative validation results show that quantifying the dynamic performance during hydrofoil pitching oscillation and using the optimal Latin hypercube design method and Kriging approximation model for optimizing the Gurney flap structure is rational and accurate. This study explores the mechanism of the Gurney flap through in-depth CFD numerical simulations and finds that the Gurney flap affects the flow characteristics at the hydrofoil’s trailing edge, thereby influencing the performance. It increases the pressure difference between the pressure and suction surfaces, thus enhancing the hydrofoil’s lift. Finally, this article provides three recommended parameters to improve the dynamic performance of the hydrofoil. This research can serve as a reference for the application of Gurney flaps in tidal turbine blade design.

Multi-Objective Optimization Design of Dynamic Performance of Hydrofoil with Gurney Flap

The horizontal axis tidal turbine, as a crucial device for capturing tidal energy, has gained significant attention because it has better energy efficiency performance. Enhancing the performance of foils, a vital part of tidal turbine blades, can significantly improve tidal turbine performance. Among numerous methods to enhance the foil performance, the Gurney flap has gained significant attention due to its avoidance of complex structural design. Currently, there is limited research on optimizing the design of Gurney flaps while considering the dynamic performance of foils. In this study, the S809 foil with a blade cross-section was selected as the research subject, a multi-objective optimization design platform was created by integrating a multi-objective optimization algorithm with Computational Fluid Dy-namics (CFD) numerical simulation techniques. The objective of this platform is to enhance the dynamic performance of the hydrofoil by optimizing the geometric structure of the Gurney flap. The improvement of dynamic lift and the size of the dynamic stall hysteresis loop are used as objective variables in this study to evaluate the hydrofoil’s dynamic performance. The optimal Latin hypercube design method is used in the optimization process to choose sample locations, and the Kriging approximation model is used to determine the relationship between the design variables and the objective variables. Meanwhile, the Non-Dominated Sorting Genetic Algorithm-II (NSGA-II) is used to create a multi-objective optimization platform for solving the optimization problem, and the optimized results are validated using CFD. Comparative validation results show that quantifying the dynamic performance during hydrofoil pitching oscillation and using the optimal Latin hypercube design method and Kriging approximation model for optimizing the Gurney flap structure is rational and accurate. This study explores the mechanism of the Gurney flap through in-depth CFD numerical simulations and finds that the Gurney flap affects the flow characteristics at the hydrofoil’s trailing edge, thereby influencing the performance. It increases the pressure difference between the pressure and suction surfaces, thus enhancing the hydrofoil’s lift. Finally, this article provides three recommended parameters to improve the dynamic performance of the hydrofoil. This research can serve as a reference for the application of Gurney flaps in tidal turbine blade design.

Design Method of Freeform Surface Optical Systems with Low Coupling Position Error Sensitivity.

Freeform off-axis reflective systems are significantly more difficult to align and assemble owing to their asymmetric surface shapes and system structures. In this study, a freeform surface system design method with low coupling position error sensitivity (FCPESM) was proposed. First, we established a mathematical model of a reflective system when it was perturbed by coupling position errors and used the clustering-microelement method to establish the coupling error sensitivity evaluation function. The evaluation function was then applied to the design process of a freeform surface off-axis three-mirror optical system. The results showed that the FCPESM optical design method can significantly relax the assembly tolerance requirements of optical systems on the basis of ensuring image performance. In this study, the reflective system was perturbed by tilt and decenter simultaneously, and the disturbance mechanism of position errors on optical systems was further improved. Through this research, freeform surface systems with both image performance and error sensitivity can be obtained, which makes freeform off-axis reflective systems with better engineering realizability.

Knowledge-based heuristic optimisation technique for mm-wave 5G antenna

ABSTRACT This work presents a knowledge-based decision-making robust antenna design (KDRAD) method that employs a heuristic-optimisation technique for antenna design. The method is used to create and scale a single-element antenna to operate at multiple frequencies within the 5 G range. In this study, a low-profile planar four-element microstrip antenna of 14.8 mm × 14.8 mm × 0.508 mm gives simulated and measured impedance bandwidths of about 1.18 GHz (26.43–27.61 GHz) and 1.08 GHz (26.42–27.50 GHz), respectively, with a centre frequency of 27 GHz. The mm-wave planar four-port antenna has a maximum gain of 7.2 dBi; isolation of 33.2 dB; and multiple antenna matrices with minimal ECC (0.000000109), high diversity gain (10 dB) and channel capacity loss of 0.00110 bits/s/Hz.

Numerical investigation and design methods of the local buckling of WAAM stainless steel circular hollow section stub columns

3D printing is an advanced technology that has been used in biomedical and automotive engineering, and has raised a significant response in civil engineering. Wire and arc additive manufacturing (WAAM), a metal 3D printing technology, has prospective applications in steel construction because it can fabricate large-scale structural members at an acceptable cost and manufacturing efficiency. Fundamental studies are still urgently needed to realize its engineering application. However, due to the irregular geometric features, limited studies on the structural performance of WAAM components, particularly the numerical studies, have been carried out. To this end, a numerical investigation on the local buckling of WAAM stainless steel circular hollow section (CHS) stub columns under axial compression has been conducted and presented herein. The finite element (FE) models were established and validated against the existing experimental research. Parametric studies were subsequently carried out to broaden the cross-sectional resistance data pool using the developed FE models. The applicability of the cross-section design provisions specified in EN 1993-1-4:2006 + A2:2020, ANSI/AISC 370-21 and the continuous strength method (CSM) for the design of WAAM CHS was evaluated according to the experimental and FE results. Furthermore, a modified design method with improved accuracy was suggested.

Design of Adaptive Grippers for Fruit-Picking Robots Considering Contact Behavior

Adaptability to unstructured objects and the avoidance of target damage are critical challenges for flexible grippers in fruit-picking robots. Most existing flexible grippers have many problems in terms of control complexity, stability and cost. This paper proposes a flexible finger design method that considers contact behavior. The new approach incorporates topological design of contact targets and introduces contact stress constraints to directly obtain a flexible finger structure with low contact stress and good adaptability. The study explores the effects of design parameters, including virtual spring stiffness, volume fraction, design domain size, and discretization, on the outcomes of the flexible finger topology optimization. Two flexible finger structures were selected for comparative analysis. The experimental results verified the effectiveness of the design method and the maximum contact stress was reduced by about 70%. An adaptive two-finger gripper was developed. This design allows the gripper to achieve damage-free grasping without additional sensors and control systems. The adaptive and contact performances of the grippers with different driving modes were analyzed. Practical grasping tests were also performed, including evaluation of adaptive performance, stability, and maximum grasping weight. The results indicate that gripper 2 with flexible finger 2 excelled in contact stress and adaptive wrapping, making it well-suited for grasping unstructured and fragile objects. This paper provides valuable insights for the design and application of flexible grippers for picking robots, offering a promising solution to enhance adaptability while minimizing target damage.

New Strategies for Responding to SARS-CoV-2: The Present and Future of Dual-Target Drugs.

The 2019 coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in millions of deaths, posing a serious threat to public health and safety. Rapid mutations of SARS-CoV-2 and complex interactions among multiple targets during infection pose a risk of expiry for small molecule inhibitors. This suggests that the traditional concept of "one bug, one drug" could be ineffective in dealing with the coronavirus. The dual-target drug strategy is expected to be the key to ending coronavirus infections. However, the lack of design method and improper combination of dual-targets poses obstacle to the discovery of new dual-target drugs. In this Perspective, we summarized the profiles concerning drug design methods, structure-activity relationships, and pharmacological parameters of dual-target drugs for the treatment of COVID-19. Importantly, we underscored how target combination and rational drug design illuminate the development of dual-target drugs for SARS-CoV-2.

Research on the Optimization Method of Project-Based Learning Design for Chinese Teaching Based on Interference-Tolerant Fast Convergence Zeroing Neural Network

The system known as project-based learning, which is applied to specific courses without compromising the coverage of the necessary technical material, uses projects to drive knowledge. The plan and implementation of project-based learning in Chinese teaching as a major project, which embraces undergraduate creativity and places an emphasis on real-world, open-ended projects are discussed in this paper. In this paper, research on optimization method of project-based learning design for Chinese teaching based on optimized interference-tolerant fast convergence zeroing neural network (PBLD-ITFCZNN-BRO). It consists of three stages, import phase, main stage and evaluation stage. In the initial phase, the teacher separated the students to groups before the lecture to make sure that every group poses various traits, with some strong leadership skills and hands-on skills. The second phase of the PBL procedure helped transform what is primarily a passive learning environment (taking notes, listening, and sitting) into a more dynamic, student-centered, and interactive one. Students presented data, articulated their concepts, and then optimized their approaches to problem-solving during the evaluation step. The teachers concluded by summarizing. The performance of the proposed PBLD-ITFCZNN-BRO approach contains 15.26%, 20.42% and 21.27% greater accuracy, and 15.61%, 17.50% and 20.24% greater precision rate, compared with Investigation of Computer Network Technology on New Media Problem-Basis Learning Teaching Mode (CNT-PBLTM), PBL Model Basis application on Deep Learning in Physical Education Classroom Integrating Production with Education (PBL-DL-PEC), Interdisciplinary project-based learning: experiences with reflections from teaching electronic engineering at china (PBL-EEC) techniques, respectively.

Design of cold-formed high strength steel irregular octagonal hollow section columns

This paper presents experimental numerical investigations on the structural behaviour of cold-formed high strength steel irregular octagonal hollow section (OctHS) columns with both non-slender and slender cross-sections. An experimental programme, including material tests, measurements of initial global geometric imperfection, and pin-ended column tests, was first conducted. The key findings from the experimental programme are presented and discussed. Following the validation against the experimental results, the proposed finite element modelling methodology was established to replicate the test observations, and then was adopted to generate a boarder range of numerical results through parametric studies. The collected experimental and numerical data were used to evaluate the applicability of current structural steel design methods on the column buckling strength for irregular OctHS columns. Assessment results demonstrate that the design method adopted in Chinese code can provide accurate prediction, whilst modified design method adopted in Eurocode 3, considering the effect of steel grade on the column strength, has been proposed and shown to greatly enhance the prediction accuracy with improved consistency. The corresponding assessments on the design approaches adopted in American and Australian codes were also discussed.

A knowledge graph-aided decision guidance method for product conceptual design

In the fast-paced world of product design, businesses seek a competitive edge by swiftly addressing user requirements and developing precise solutions. Depending on diverse knowledge, conceptual design makes enterprises invest significantly in knowledge management. Following the philosophy of decision-based design, a knowledge graph-aided decision guidance method is proposed to streamline and enhance knowledge utilisation in product conceptual design. Firstly, the decision-making process in product conceptual design is modelled using the Concept-Decision-Knowledge (CDK) model, yielding the meta-model of CDK (mCDK). A data-augmented BERT-BiLSTM-CRF model is adopted to extract information from diverse data sources, forming a CDK knowledge graph (CDK-KG). A decision case for employing problem-solving knowledge configuration is generated to resolve specific design decision problems when new requirements arise. Validation of the method is demonstrated through a case study on the launch vehicle conceptual design of the first and second-stage separation system. The results indicate that the proposed method can automatically extract information from data resources to construct a knowledge graph. Furthermore, it can provide decision cases for design requirements through knowledge configuration, supporting decision-making.

Pengaruh Angin Terhadap Tata Letak dan Jumlah Sekrup Konstruksi Baja Ringan Berdasarkan SNI-7971- 2013

Light weight steel material has experienced rapid development in the construction. However, there are still many costruction failures on light weight steel, resulting in cost loss. The failure of light steel structures often occurs at the connections. The connection tool on milld steel is usually using a self-drilling screw. The research location is at Aceh One Stop Integrated Service and Investment Service Building (DPMPTSP) Aceh. The problem in this study is the placement and number of screws on the lightweight steel roof structure in the field which is carried out for each member according to the code, and the effect of wind load on the placement and number of screws on the lightweight steel roof structure. This study aims to determine the effect of the placement and number of screws on the lightweight steel roof structure. The scope of this research of problems including the placement and number of screws on the lightweight steel roof structure. The standars used in the design of light steel structures in this study is SNI 7971 2013 and the loading planning standars using SNI 03 1727 1989. Calculation steps using the LRFD method for steel structure design regulated in SNI 03 1729 2002. Based on the results, it is obtained that the number and placement of the screws in the field are different from those obtained in the calculation. From the calculations, it is obtained from the recapitulation, dead loads with a maximum value of 123.07 kg, live loads with a maximum load of 30.1 6 kg, and for compressed air and suction loads with a maximum load of 180 kg. the maximum design force value is 1241.33 kg and the screws bearing resistance value is 256.752 kg. the number of screws is obtained where the the value of the design force is divided by the value of the bearing resistance, on each member obtained 1screw, 2 screws, 3 screws, 4 screws, and 5 screws. Whilst it is found for each member in the field using 3 screws.

Discrete Adjoint Optimization Method for Low-Boom Aircraft Design Using Equivalent Area Distribution

This paper introduces a low-boom aircraft optimization design method guided by equivalent area distribution, which effectively improves the intuitiveness and refinement of inverse design. A gradient optimization method based on discrete adjoint equations is proposed to achieve the fast solution of the gradient information of target equivalent area distribution relative to design variables and to drive the aerodynamic shape update to the optimal solution. An optimization experiment is carried out based on a self-developed supersonic civil aircraft configuration with engines. The results show that the equivalent area distribution adjoint equation can accurately solve the gradient information. After optimization, the sonic boom level of the aircraft was reduced by 13.2 PLdB, and the drag coefficient was reduced by 60.75 counts. Moreover, the equivalent area distribution adjoint optimization method has outstanding advantages, such as high sensitivity and fast convergence speed, and can take both the low sonic boom and the low drag force of the aircraft into account, providing a powerful tool for the comprehensive optimization design of supersonic civil aircraft by considering sonic boom and aerodynamic force.

Communication and visual identity through system design:

The curricular unit of Project of the 3rd year of the Degree in Design and Graphic Production aims to apply the knowledge and methodologies acquired. The students are expected to de- velop a visual identity project for a cultural space surrounding the school called TOBIS. The identity of this multi-purpose space, equipped to host various events in areas such as cinema, theatre, music and exhibitions and others, must be based on a comprehensive communication project. Through a case study, we propose to analyse how the students understand and apply the systems design method in solving this challenge.

Tailoring Phonon Dispersion of a Genetically Designed Nanophononic Metasurface.

Phonon engineering at the nanoscale holds immense promise for a myriad of applications. However, the design of phononic devices continues to rely on regular shapes chosen according to long-established simple rules. Here, we demonstrate an inverse design approach to create a two-dimensional phononic metasurface exhibiting a highly anisotropic phonon dispersion along the main axes of the Brillouin zone. A partial hypersonic bandgap of approximately 3.5 GHz is present along one axis, with gap closure along the orthogonal axis. Such a level of control is achieved through genetically optimized unit cells, with shapes exceeding conventional intuition. We experimentally validated our theoretical predictions using Brillouin light scattering, confirming the effectiveness of the inverse design method. Our approach unlocks the potential for automated engineering of phononic metasurfaces with on-demand functionalities, thus leading toward innovative phononic devices beyond the limitations of traditional design paradigms.

Parameter Design Method for Destressing Boreholes to Mitigate Roadway Coal Bursts: Theory and Verification

Parameter Design Method for Destressing Boreholes to Mitigate Roadway Coal Bursts: Theory and Verification

Optimization of the Factors Affecting Biogas Production Using the Taguchi Design of Experiment Method

The present study analyzed the effect of temperature, pH, pre-treatment and mixing ratio on the anaerobic digestion process. The parameters during the anaerobic co-digestion of cow manure and food waste were then optimized using the Taguchi experimental design method. ANOVA was carried out to find the significant parameters which influence biogas production. Experimental tests were carried out at laboratory-scale reactors kept at different temperatures (28 °C, 35 °C, and 50 °C). The specific methanogenic performance (SMP) during anaerobic digestion at higher temperatures was characterized with the analysis of acetate, propionate, butyrate, hydrogen, glucose, and formate, and was validated with the literature. The improvement of biogas production with different pre-treatments, i.e., ultrasonic, autoclave, and microwave techniques, was also analyzed. The results showed that the reactor that was maintained at 35 °C showed the highest biogas production, while the reactor that was maintained at a lower temperature (28 °C) produced the lower volume of biogas. As the retention time increases, the amount of biogas production increases. Methanogenic activities of microorganisms were reduced at higher temperature conditions (65 °C). Biogas production increased by 28.1%, 20.23%, and 13.27% when the substrates were treated with ultrasonic, autoclave, and microwave, respectively, compared to the untreated substrate. The optimized condition for the highest biogas production during anaerobic co-digestion of food waste and cow manure is a temperature of 35 °C, a pH of 7 and a mixing ratio (CM:FW = 1.5:0.5). ANOVA showed that temperature is the most important input parameter affecting biogas production, followed by mixing ratio.

A novel biosorbent material from waste fish scales (Cyprinus carpio) for biosorption of toxic dyes in aquatic environments

AbstractPolluted water sources are a growing concern in our world today, with more and more of our precious freshwater sources becoming contaminated. Pollution can come from a variety of sources, such as industrial discharge, agricultural runoff, and even urban runoff. Several treatment technologies have been investigated, mainly for dye pollution from textile and industrial wastes. In this study, the biosorption of methylene blue dye from the water environment was examined utilizing a low-cost and biodegradable biomaterial. Waste fish scales modified with NaOH were used as biomaterial. The biosorption effect of methylene blue concentration and pH variables was optimized. SEM for the surface morphology of the biomaterial and FT-IR analyses for the detection of functional groups were performed. The characterization of methylene blue biosorption was conducted to fully understand its nature, including its kinetics, equilibrium, and thermodynamic works. It has been determined that the biosorption process conforms most closely to the pseudo-second-order kinetic model for its kinetic results and to the Langmuir isotherm for its equilibrium results. Based on the Langmuir isotherm data, the maximum capacity for biosorption (qmax) was found to be 344.82 mg g−1. The thermodynamic results showed that the process of biosorption of methylene blue on various surfaces is spontaneous and occurs via physisorption. Additionally, the experimental design method was utilized to determine the optimum conditions of the methylene blue biosorption process under various conditions. The maximum biosorption capacity was determined to be 102.367 mg g−1 at the optimal conditions. The potential of biosorbent derived from the waste fish scales is promising as a novel biosorbent material due to its unique surface morphology and high biosorption capacity.

An optimal combination of four active components in Huangqin decoction for the synergistic sensitization of irinotecan against colorectal cancer

BackgroundIrinotecan (CPT-11) is a first-line treatment for advanced colorectal cancer (CRC). Four components (baicalin, baicalein, wogonin, and glycyrrhizic acid) derived from Huangqin Decoction (HQD) have been proven to enhance the anticancer activity of CPT-11 in our previous study.ObjectiveThis study aimed to determine the optimal combination of the four components for sensitizing CPT-11 as well as to explore the underlying mechanism.MethodsThe orthogonal design method was applied to obtain candidate combinations (Cmb1-9) of the four components. The influence of different combinations on the anticancer effect of CPT-11 was first evaluated in vitro by cell viability, wound healing ability, cloning formation, apoptosis, and cell cycle arrest. Then, a CRC xenograft mice model was constructed to evaluate the anticancer effect of the optimal combination in vivo. Potential mechanisms of the optimal combination exerting a sensitization effect combined with CPT-11 against CRC were analyzed by targeted metabolomics.ResultsIn vitro experiments determined that Cmb8 comprised of baicalin, baicalein, wogonin, and glycyrrhizic acid at the concentrations of 17 μM, 47 μM, 46.5 μM and 9.8 μM respectively was the most effective combination. Importantly, the cell viability assay showed that Cmb8 exhibited synergistic anticancer activity in combination with CPT-11. In in vivo experiments, this combination (15 mg/kg of baicalin, 24 mg/kg of baicalein, 24 mg/kg of wogonin, and 15 mg/kg of glycyrrhizic acid) also showed a synergistic anticancer effect. Meanwhile, inflammatory factors and pathological examination of the colon showed that Cmb8 could alleviate the gastrointestinal damage induced by CPT-11. Metabolic profiling of the tumors suggested that the synergistic anticancer effect of Cmb8 might be related to the regulation of fatty acid metabolism.ConclusionThe optimal combination of four components derived from HQD for the synergistic sensitization of CPT-11 against CRC was identified.

EVALUASI TEKNIS KONSEP PADA DESAIN ALAT PENEBAR PUPUK BUTIRAN

The technique of spreading fertilizer on rice plants is an important part of equalizing land fertility. In general, farmers use their hands to spread granular fertilizer. The spreading process results in an irregular distribution of fertilizer and also takes a relatively long time. The aim of this research is to design a granular fertilizer spreader based on a technical evaluation of the concept. The Pahl and Beitz design method became a theoretical reference in finalizing the design of the granular fertilizer spreader form. Working drawings are prepared based on ISO standards using Solidwork 2018 software. Based on the results of the technical evaluation of the concept, the design of the granular fertilizer spreader is composed of thirty-three constituent components.