Disease prediction is an important aspect of modern medicine, which aims to diagnose disease early and provide appropriate treatment to patients. This research uses a hybrid approach that combines the RBF (Radial Basis Function) kernel algorithm with logistic regression to predict various diseases in medical datasets. This method is intended to improve prediction performance by exploiting the advantages of each algorithm. This research uses a dataset containing medical information about several diseases collected from the Kaggle dataset. First, the RBF kernel is applied to transform the data features into a more informative, non-linear representation. Then, the logistic regression model is used to make predictions based on the features that have been processed by the RBF kernel. In this research, the hybrid RBF (Radial Basis Function) method was proven to be superior in predicting multiple diseases. This method shows the highest accuracy of 0.9460, as well as excellent precision, recall, and F1-score values of 0.8680, 0.8097, and 0.8294, respectively. The advantage of the hybrid RBF method lies in its ability to capture complex patterns in data that other methods often cannot identify, as well as its ability to handle non-linear decision boundaries, which are a common characteristic in medical datasets. Keywords: Disease prediction, Hybrid approach, RBF kernel algorithm, Logistic regression, medical datasets