Epilepsy, a prevalent neurological disorder characterized by disrupted brain activity, affects over 70 million individuals worldwide, as reported by the World Health Organization (WHO). The development of computer-aided diagnosis systems has become vital in assessing epilepsy severity promptly and initiating timely treatment. These systems enable the detection of epileptic seizures by analyzing the electrical activity in the EEG recordings of the patients. In addition, it helps doctors to choose suitable treatment by quickly determining the type, duration, and characteristics of seizures and increases the patient's quality of life. The proposed computer-aided diagnosis system in this study comprises three modules: preprocessing, feature extraction, and classification. The initial module employs a low-pass Chebyshev II filter to eliminate noise artifacts from signal recordings. The second module involves deriving feature vectors using Bispectrum Analysis, Empirical Mode Decomposition, Discrete Wavelet Transform, and Wavelet Packet Analysis. The third module employs the Artificial Neural Networks method for epileptic seizure detection. This study not only enables the comparison of feature extraction efficacy among Bispectrum Analysis, Empirical Mode Decomposition, Discrete Wavelet Transform, and Wavelet Packet Analysis techniques, but it also reveals that Bispectrum Analysis and Empirical Mode Decomposition yield the highest accuracy rate. The method achieves 100% accuracy in detecting epileptic seizures. Additionally, sensitivity analysis has been conducted to enhance the success of Discrete Wavelet Transform and Wavelet Packet Analysis methods and to identify significant features.
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