Since the structural vibration deformation of a large antenna under wind disturbance leads to the pointing deterioration, an adaptive anti-wind disturbance system was presented by Liang et al. (Int. J. Antennas Propag., Article ID 2015341, 2019). To further improve the vibration suppression performance, this paper presents a locations-optimization algorithm of multiple cable-drivers for the anti-wind disturbance system. First, according to the spatial geometric relationship among the antenna structure, single slide track, four cables and drivers, the feasible domain of the drivers is determined. Next, the separate optimization method, and the joint optimization method for the locations of the four drivers are proposed, respectively. Finally, the simulation implementation of a 7.3 m antenna under various wind conditions is used to compare the joint optimization method and the separate optimization method.