In this article, we propose a new method of bias reduction in nonparametric regression estimation. The proposed new estimator has asymptotic bias order h 4 , where h is a smoothing parameter, in contrast to the usual bias order h 2 for the local linear regression. In addition, the proposed estimator has the same order of the asymptotic variance as the local linear regression. Our proposed method is closely related to the bias reduction method for kernel density estimation proposed by Chung and Lindsay (2011). However, our method is not a direct extension of their density estimate, but a totally new one based on the bias cancelation result of their proof.