Methamphetamine Overdose Research Articles

Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats

The roles of monoclonal antibody affinity and treatment time of (+)-methamphetamine-induced pharmacological effects in rats were studied using two anti-(+)-methamphetamine monoclonal antibodies. These studies tested the preclinical protective effects of monoclonal antibody antagonists in (+)-methamphetamine overdose and pretreatment scenarios. The higher affinity antibody (mAb6H4; K D = 11 nM for (+)-methamphetamine) more effectively antagonized (+)-methamphetamine-induced behavioral effects (distance and rearing) than the low affinity antibody (designated mAb6H8; K D = 250 nM) and had a longer duration of action. Both antibodies more effectively reduced (+)-methamphetamine effects in the overdose model than in the pretreatment model. (+)-Methamphetamine pharmacokinetic studies showed the mAb6H4 significantly reduced brain concentrations over time in both models. However, while mAb6H4 immediately reduced brain concentrations in the overdose model, it did not prevent the initial distribution of (+)-methamphetamine into the brain in the pretreatment model. Thus, anti-(+)-methamphetamine monoclonal antibody affinity and administration time (relative to (+)-methamphetamine dosing) are critical determinants of therapeutic success.

Methamphetamine overdose

Clinical Trauma Liaison Nurse • Emergency and Trauma Center • St. Joseph's Baptist Hospital • Tampa, Fla.

A Fatal Methamphetamine Overdose at the Site of a Clandestine Laboratory

Fatalities from methamphetamine overdose remain relatively rare despite its widespread abuse. A case history involving a fatal methamphetamine overdose at the site of a clandestine laboratory is presented. Evidence from the scene, a record of conversations relevant to the victim's state of intoxication prior to death as well as pathological and toxicological findings are reviewed.

Methamphetamine overdose

Methamphetamine overdose