Metastatic Crohn's Disease Research Articles

Metastatic Crohn′s disease

Crohn's disease, first described in 1922, is characterized by segmental granulomatous inflammation of the intestinal tract and frequently involves the cutaneous tissues as well. Cutaneous Crohn's disease (CCD) is synonymous with metastatic Crohn's disease (MSD). A case of CCD, without any gastrointestinal involvement is reported for its rarity.

Pozajelitowa skórna choroba Leśniowskiego-Crohna (przerzutowa choroba Leśniowskiego-Crohna)

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Rożalski M. Extraintestinal Crohn's disease (metastatic Crohn's disease). Dermatology Review/Przegląd Dermatologiczny. 2014;101(5):418-422. doi:10.5114/dr.2014.46074. APA Rożalski, M. (2014). Extraintestinal Crohn's disease (metastatic Crohn's disease). Dermatology Review/Przegląd Dermatologiczny, 101(5), 418-422. https://doi.org/10.5114/dr.2014.46074 Chicago Rożalski, Michał. 2014. "Extraintestinal Crohn's disease (metastatic Crohn's disease)". Dermatology Review/Przegląd Dermatologiczny 101 (5): 418-422. doi:10.5114/dr.2014.46074. Harvard Rożalski, M. (2014). Extraintestinal Crohn's disease (metastatic Crohn's disease). Dermatology Review/Przegląd Dermatologiczny, 101(5), pp.418-422. https://doi.org/10.5114/dr.2014.46074 MLA Rożalski, Michał. "Extraintestinal Crohn's disease (metastatic Crohn's disease)." Dermatology Review/Przegląd Dermatologiczny, vol. 101, no. 5, 2014, pp. 418-422. doi:10.5114/dr.2014.46074. Vancouver Rożalski M. Extraintestinal Crohn's disease (metastatic Crohn's disease). Dermatology Review/Przegląd Dermatologiczny. 2014;101(5):418-422. doi:10.5114/dr.2014.46074.

Metastatic Crohn's disease in genital and perianal area preceding 11 years intestinal Crohn's disease

Metastatic <scp>C</scp>rohn's disease in genital and perianal area preceding 11 years intestinal <scp>C</scp>rohn's disease

Cutaneous Crohn's disease treated with infliximab and 4 years of follow up

Metastatic Crohn's disease (MCD) is a rare, non-contiguous cutaneous manifestation of Crohn's disease. To date, there have been only four reports in the literature of an effective treatment of this condition with infliximab and there are no long-term follow-up studies on adult MCD patients treated with infliximab. We present a case of MCD treated with infliximab with 4.5 years of follow up.

Penile Crohn's disease resolved by infliximab

Crohn's disease is a chronic relapsing, granulomatous, and inflammatory bowel disorder. Variable extra-intestinal manifestations may occur, which include erythema nodosum, erythema multiforme, pyoderma gangrenosum, and other non-specific skin lesions. Here, we present a case of metastatic penile Crohn's disease without scrotal involvement, which was initially approached as a balanoposthitis with penile cellulitis, and completely treated with infliximab infusion in a short time.

Anti-tumor necrosis factor-α induced systemic lupus erythematosus in a patient with metastatic Crohn's disease—what is the role of anti-TNF antibody?

Biological therapies are supposed to trigger the development of autoimmune diseases. We report a case of a 27-year old woman presenting with drug induced systemic lupus erythematosus (SLE) associated with infliximab therapy. The development of paradoxical inflammation in immune-mediated inflammatory diseases patients treated with anti TNF-α suggests that an unknown inflammatory pathway may be provoked by inhibiting TNF-α. We suppose that in our case a cross reactivity between anti-infliximab antibodies and autoantibodies may lead to the development of TNF-induced immune disease.

Isolated penile lymphedema in an adolescent male: A case of metastatic Crohn's disease

ObjectiveMetastatic Crohn's disease is a rare and complex inflammatory condition distinguished by cutaneous granulomatous lesions outside the gastrointestinal tract. Genital involvement is rare; with less than 10 cases reported involving isolated penile lymphedema. Here, we present a case of isolated lymphedema of the penis as a consequence of extra-intestinal Crohn's disease. Case reportThe patient is an 18-year-old African American male with a complex history of inflammatory bowel disease, who initially presented with a chief complaint of 6 weeks of swelling of his penis at age 13. A modified circumcision and lymphangectomy of the penis were performed; histopatholgy demonstrated a granulomatous infiltrate and interstitial edema of the distal penis. ConclusionSurgical intervention is an applicable therapeutic alternative and last-line therapy for treatment of isolated penile lymphedema in select patients with appropriate pathology, and can be a suitable adjunct to medical management in these cases.

Enfermedad de CROHN metastásica: respuesta a intensificación de tratamiento con adalimumab

Inflammatory bowel disease is accompanied by extraintestinal manifestations in a high percentage of patients. Cutaneous lesions are the second most prevalent of these manifestations, and within these, metastatic Crohn's disease is one of the least common, being the least frequent specific cutaneous manifestation of Crohn's disease. This entity includes cutaneous and subcutaneous lesions with a non-caseating granulomatous appearance on histological analysis identical to that of Crohn's disease. These lesions are not found adjacent to the digestive tract. Due to the low prevalence of these manifestations, conclusive trials on the treatment of choice have not been performed and there is no well-defined therapeutic strategy. Distinct therapies with varying results have been reported.We report the case of a female patient with longstanding and complex Crohn's disease who developed metastatic cutaneous manifestations while receiving adalimumab. The cutaneous manifestations responded well to dose intensification of this drug. A review of the literature is provided.

Cutaneous metastatic Crohn disease of the leg

Cutaneous metastatic Crohn disease of the leg

Metastatic Crohn Disease: A Rare Cutaneous Entity

Metastatic Crohn disease is a rare cutaneous disorder characterized by noncaseating, granulomatous skin lesions present at sites anatomically separate from the gastrointestinal tract. It is the least common dermatologic manifestation of Crohn disease, and the differential diagnosis includes numerous similarly appearing, granulomatous skin entities. Males and females appear to be equally affected, and children tend to present with clinical lesions different from those of adults. An integration of clinical information, microscopic findings, and ancillary studies is necessary to accurately diagnose this rare cutaneous disease. Our objective is to review the clinical features, histopathologic characteristics, suggested pathogenesis, differential diagnosis, and current therapeutic options of metastatic Crohn disease.

Surgical management of gluteal metastatic cutaneous Crohn's disease

Metastatic cutaneous Crohn's disease is a rare entity first described by McCallum et al. in 1976. It is diagnosed when histologically characteristic granulomata are seen at a site not contiguous with inflammatory disease in the gastrointestinal tract. We herein report presentation, diagnosis and management of a 28year old lady with disabling, symptomatic cutaneous Crohn's of the buttocks and natal cleft refractory to Infliximab therapy. To the best of our knowledge only four other adult cases have been reported in the literature of metastatic cutaneous Crohn's disease of the buttock area distant from a flexure or area of skin apposition. The differential diagnosis in this case was Hidradenitis Suppurativa. A good cosmetic result and excellent symptom control were achieved with extensive debridement, wide local excision, vacuum assisted closure and delayed skin grafting.

Metastatic cutaneous Crohn’s disease of the face

Metastatic cutaneous Crohn's disease is one of the most uncommon cutaneous extraintestinal manifestations. The face is the rarest location, with only eight cases described in the literature. We report a rare case of a young man with Crohn's disease and two granulomatous lesions on the face in a nodular form. To the best of our knowledge, this is the first report of metastatic Crohn's disease of the forehead with the features of nodules. A review of the literature concerning metastatic Crohn's disease is also provided.

Poster 481 Metastatic Crohn Disease Manifesting as Skin Ulcerations in a Stroke Patient With Quadriplegia: A Case Report

Poster 481 Metastatic Crohn Disease Manifesting as Skin Ulcerations in a Stroke Patient With Quadriplegia: A Case Report

Metastatic Crohn’s disease of the penis: two cases

Metastatic Crohn's disease is a rare inflammatory process that is non-contiguous from the bowel. It can affect the penis and is variable in presentation and onset in relation to bowel symptoms. It has been treated with oral, topical, systemic, and surgical therapies. We describe our experience with two cases of penile metastatic Crohn's disease and their management in comparison with other cases described in the literature. Both our patients were of the lymphoedematous type and had sexual and voiding dysfunction. They were treated with topical and intra-lesional steroids and circumcision after unsuccessful systemic treatments.

Metastatic Crohn disease: Clearance with metronidazole

Metastatic Crohn disease: Clearance with metronidazole

Cutaneous metastatic Crohn disease: A rare case report and review

Cutaneous metastatic Crohn disease: A rare case report and review

Chronic linear ulcerations of the inguino-crural and buttocks folds

Vulvo-perineal Crohn's disease is a rare condition either when it is isolated or associated with digestive manifestations. In the former condition named metastatic Crohn's disease, it may constitute a diagnostic challenge and may be confused especially with other infectious or inflammatory disorders. We report a case of vulvo-perineal Crohn's disease in a 46-year-old woman. A 46-year-old woman was diagnosed with a vulvo-perineal Crohn's disease without digestive involvement. There was a chronic edema of the vulva with linear ulcerations on the inguino-crural regions and the buttocks fold, of 3 years. Treatment with metronidazole (1 g/day for 6 months) led to almost complete healing of the ulcerations with a sustained result. Physicians must be aware of the diverse manifestations and confusing presentations of vulvo-perineal Crohn's disease.

Metastatic Crohn Disease

Cutaneous Crohn disease is an uncommon but important granulomatous disorder of the skin. We present a case of metastatic Crohn disease and review the differential diagnosis of cutaneous granulomatous disorders including orofacial granulomata, sarcoidosis, foreign body granulomata, necrobiotic disorders, and fungal infections of the skin.

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with systemic diseases that impact the patient's overall prognosis. In this update, we offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions that have implications for systemic disease: granuloma annulare, annular elastolytic giant cell granuloma, necrobiosis lipoidica, methotrexate-induced accelerated rheumatoid nodulosis, necrobiotic xanthogranuloma, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, palisaded neutrophilic granulomatous dermatitis, sarcoidosis, and metastatic Crohn disease. Recent clinical, epidemiologic, and laboratory studies have shed some light on these diseases, the association of these conditions with systemic disorders, and their overall prognoses.

Enfermedad de Crohn metastásica

Metastatic Crohn's disease is a granulomatous cutaneous lesion that appears in patients with Crohn′s disease and is located in any skin area, separated from the lesions in the gastrointestinal tract. This entity is characterized by its heterogeneous behavior, both in its localization and clinical expression and in its effect on patients’ quality of life. Histology is essential for diagnosis and shows non-caseating granulomas. There are no treatment guidelines and various therapeutic strategies have been employed, with variable response. In most patients, treatment with biological agents is highly effective. We describe three cases of metastatic Crohn's disease with the aim of analyzing the characteristics of this entity, which should always be included in the differential diagnosis of skin lesions in patients with Crohn's disease. A literature review is also provided.