Metastatic Ameloblastoma Research Articles

Ameloblastic Carcinoma of the mandible

Odontogenic carcinomas are rare lesions arising from dental embryogenic residues and have been designated by a variety of terms like malignant ameloblastoma, ameloblastic carcinoma, metastatic ameloblastoma or primary intra-alveolar epidermoid carcinoma. Ameloblastic carcinoma combines the histological features of ameloblastoma with cytological atypia, even in the absence of metastasis. The lesion has been reported to arise either from the odontogenic cyst or the ameloblastoma. Majority originate de novo and the remaining are malignant transformation of an ameloblastoma.

Metastatic Ameloblastoma to the Cervical Lymph Nodes: A Case Report and Review of Literature

Ameloblastomas make up 1% of all tumors found in the oral cavity.1 They occur 80% of the time in the mandible, and 20% of the time in the maxilla.2-5 Ameloblastomas are benign tumors that are locally aggressive. Recurrence rates have been reported as high as 50% to 72%, depending on treatment modality.1 Malignant ameloblastoma is defined as a histologically benign-appearing ameloblastoma with metastasis.2 Metastasis most commonly occurs in the lungs (75% to 88% of cases) and lymph nodes (15% to 27% of cases), but is also seen in the liver, brain, bones, kidneys, and intestines.

Malignant ameloblastoma metastasis to the lung: a case report

Ameloblastoma is an odontogenic tumor, usually benign, which rarely metastasizes to distant organs. The case of a 27-year-old white woman is described, who presented a metastatic pulmonary ameloblastoma 7 years after the removal of a mandibular ameloblastoma. She presented no pulmonary symptoms, but a lung nodule was found in a chest x-ray during a routine check-up for job admission. Computed tomography (CT) revealed a 2-cm well-defined solitary round nodule without calcifications, leading to the hypothesis of a metastatic tumor. Clinical and CT investigation confirmed no ameloblastoma recurrence in the jaw and no other primary tumor. The diagnosis of metastatic ameloblastoma was confirmed by microscopic evaluation of the pulmonary nodule.

高カルシウム血症を呈した肺転移悪性エナメル上皮腫の１例

The patient was a 51-year-old woman. She was referred to the Department of Respiratory Medicine at our hospital because of a persistent cough. Our department was consulted about a mandibular ameloblastoma in relation to the treatment of her pulmonary lesions. She had suffered from ameloblastoma of the right side of the mandible had undergone enucleation at another hospital in December 1975. Subsequently, a total of 5 operations for ameloblastoma of the mandible were performed over the course of 12 years. Lung metastasis was found in February 2001. In addition, the patient had hypercalcemia probably due to an elevated circulating level of parathyroid hormone-related protein (PTHrP) caused by the metastatic ameloblastoma. We report a rare case of pulmonary metastatic malignant ameloblastoma with hypercalcemia due to PTHrP production.

Metastatic malignant ameloblastoma responding to chemotherapy with paclitaxel and carboplatin

We report an unusual case of metastatic ameloblastoma, involving lung and pleura. that repeatedly responded to systemic treatment with paclitaxel and carboplatin. suggesting principle chemosensitivity of this rare disease.

Pulmonary metastasectomy in the treatment of recurrent ameloblastoma of the maxilla and mandible: a case report

Ameloblastoma is an aggressive benign tumor with frequent local recurrences. Although histologically benign, it occasionally metastasizes to many organs, most commonly to the lungs. The metastasis develops after multiple recurrences and many unsuccessful attempts at removal of the tumor. When distant metastasis occurs, the prognosis is poor and there is no effective treatment. A case of metastatic ameloblastoma of the mandible and maxilla is reported which was treated with pulmonary metastasectomy. The treatment options are discussed in relation to the literature.

Ameloblastoma. Cytologic findings and literature review.

To define and elaborate the cytomorphologic features of primary and metastatic ameloblastoma (ABL) on fine needle aspiration (FNA) and to discuss the differential diagnosis with closely related entities and review the cytologic literature on the subject. A retrospective study consisting of five cases of ameloblastomas, primary in the mandible (n = 3) and metastases (n = 2), diagnosed by FNA cytology with appropriate cytohistologic correlation, was done. Smears were stained with the Diff-Quik and Papanicolaou methods. Hematoxylin and eosin-stained sections of paraffin block as well as sections from the surgically resected specimens were also reviewed. The smears were hypercellular and occasionally showed tissue fragments of basaloid cells with peripheral palisading. A distinct, two-cell population was seen, consisting of small, hyperchromatic, basaloid-type cells and scattered larger cells with more open chromatin. Occasional fragments of mesenchymal cells with more elongated nuclei and ample, clear cytoplasm were also noted. Malignant cases that metastasized showed prominent cytologic pleomorphism, cellular crowding with molding and a high mitotic/karyorrhectic index. In the right clinical setting and with proper radiologic evidence, the cytologic features of primary and metastatic ameloblastoma are unique. Diagnostic problems may arise when these lesions are pleomorphic and frankly malignant, especially at metastatic sites, such as the lung. FNA, therefore, is a valuable diagnostic tool in the initial diagnosis and follow-up of patients with a history of ameloblastoma.

Mandibular ameloblastoma metastatic to the cavernous sinus

A 37-year-old woman presented with diplopia caused by a metastatic mandibular ameloblastoma to the cavernous sinus and subsequent spread to the orbit. Initial treatment consisted of local curretage and two local recurrences occurred prior to the cavernous sinus metastasis nine years after presentation. Although considered a benign tumor, ameloblastoma may metastasize despite a benign histologic appearance. Since metastases most often occur after multiple local recurrences, initial radical surgery should be performed.

Pulmonary Metastatic Disease in Ameloblastoma

Ameloblastoma is a rare disease of odontogenic origin with indeterminate metastatic potential. The first site of metastatic disease is usually the lung. We report aggressive surgical treatment of a patient with bilateral disease with five subsequent recurrences. A review of the literature suggests that in the absence of effective chemotherapy or radiation, surgery should be considered the treatment of choice for metastatic ameloblastoma confined to the lung.

エナメル上皮腫にきわめて類似した組織像を呈した顎下部腫りゅうの１例

An unusual case is presented of ameloblastoma arising in the submandibular region.A 50-year-old, Japanese woman. Complained of a movable, nontender mass, approximately 40 mm in diameter, in her right submandibular region. The onset of this lesion was at age 18. During the past 32 years fluid contained in this lesion occasionally was aspirated by puncture needle as treatment.Histopathology of this lesion revealed multilocular cystic tumor showing Ishikawa's Type RE ameloblastoma-like parenchyma with fibrous stroma in the lymph node. These findingssuggested that the lesion was metastatic ameloblastoma, i. e., especially malignant ameloblastoma. However, careful clinical examination failed to find the presence of the primary tumors, such as ameloblastoma of the jaw, basal cell carcinoma, squamous cell carcinoma, and craniopharyngioma.The differential diagnosis and pathogenesis of this lesion was discussed.

Metastatic ameloblastoma of the skull

A rare case of a metastatic ameloblastoma of the skull in a 29-year-old woman is reported. An ameloblastoma of the left mandible underwent histological malignant transformation following repeated operations and eventually metastasized to the left temporoparietal region of the skull. The skull tumor showed osteolytic change and marked vascularity in roentgenological examinations. It was removed totally. The histological findings were similar to those of the tumor of the left mandible. The route of the metastasis was considered to be via the left external carotid artery.

Ameloblastoma of the mandible with pulmonary metastasis.

A patient with ameloblastoma of the mandible with histologically confirmed pulmonary metastases 9 years after onset of tumor is described. The effectiveness of three chemotherapeutic agents (cyclophosphamide, methotrexate, Adriamycin), each given alone intravenously, were evaluated. Marked symptomatic improvement was noted with Adriamycin therapy. Ten previous cases of metastatic ameloblastoma are reviewed. The incidence of metastases cannot be predicted on the basis of histology. Three commonly discussed modes of metastasis are via hematogenous and lymphatic routes and the unusual mechanism of aspiration of tumor cells.

Mandibular ameloblastoma with intracerebral and pulmonary metastasis

Summary A case in which a 52-year-old woman with a 23-year history of ameloblastoma was unsuccessfully treated by multiple local surgical excisions, a hemimandibulectomy 15 years prior to death, and finally chemotherapy is reported. This patient had widespread soft-tissue recurrence in the left neck, intracranial extension, and multiple parenchymal metastases. Evidence of vascular invasion was present. This represents the eighth reported case of metastatic ameloblastoma and the third case of combined pulmonary and intracerebral extension.