Metastatic Adrenal Cortical Carcinoma Research Articles

Localization of Metastatic Adrenal Cortical Carcinoma with Ga-67

Data are limited on the localization of Ga-67 in primary or metastatic adrenal cortical carcinoma. We report the localization of Ga-67 to pathologically confirmed adrenal cortical carcinoma metastatic to the lung. A review of the literature revealed four patients have previously been reported to have metastatic adrenal cortical carcinoma detected on Ga-67 scan. Gallium imaging may be useful in the evaluation of patients with adrenal cortical carcinoma. SPECT imaging should further improve lesion resolution and localization.

5-Fluorouracil, doxorubicin, and cisplatin regimen in adrenal cortical carcinoma.

Five patients with metastatic adrenal cortical carcinoma were treated with a combination of 5-fluorouracil (5-FU), doxorubicin, and cisplatin. All patients had a nonhormone producing tumor. A large tumor burden made them unsuitable for mitotane treatment. Treatment could be evaluated in four patients. A complete remission was achieved in one patient and lasted for 38 months: this patient is still alive and free of disease. Furthermore, a minor response and a disease stabilization also were observed. Cardiotoxicity occurred in one patient and myelosuppression in another patient. This regimen appears to be an active combination for the treatment of metastatic adrenal cortical carcinoma.

Prolonged Survival Following Six Pulmonary Resections for Metastatic Adrenal Cortical Carcinoma: A Case Report

No AccessJournal of Urology1 Nov 1984Prolonged Survival Following Six Pulmonary Resections for Metastatic Adrenal Cortical Carcinoma: A Case Report D.A. Potter, C.A. Strott, N. Javadpour, and J.A. Roth D.A. PotterD.A. Potter More articles by this author , C.A. StrottC.A. Strott More articles by this author , N. JavadpourN. Javadpour More articles by this author , and J.A. RothJ.A. Roth More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)50007-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Prolonged Survival Following Six Pulmonary Resections for Metastatic Adrenal Cortical Carcinoma: A Case Report." The Journal of Urology, 132(5), p. 1061 © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 132Issue 5November 1984Page: 1061 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information D.A. Potter More articles by this author C.A. Strott More articles by this author N. Javadpour More articles by this author J.A. Roth More articles by this author Expand All Advertisement PDF downloadLoading ...

Multiple Thoracotomy Combined With Chemotherapy in Metastatic Adrenal Cortical Carcinoma: A Case Report and Review of the Literature

Multiple Thoracotomy Combined With Chemotherapy in Metastatic Adrenal Cortical Carcinoma: A Case Report and Review of the Literature

Metastatic Adrenal Cortical Carcinoma

CURRENTLY, there is a disagreement concerning the effectiveness of mitotane (o,p'-DDD) (1,1-dichloro-2-[o-chlorophenyl]-2-[p-chlorophenyl]-ethane) in the therapy for metastatic adrenal cortical carcinoma. Following the initial favorable report,¹measurable tumor response was observed in two large series in 34 %²and 61 %³of patients treated with this drug, and overall survival was prolonged when compared with an earlier group of untreated persons whose mean survival was 2.9 months. However, in another series,⁴survival was not improved. The following case is presented to illustrate a long-term remission of adrenocortical carcinoma and the effects that have been associated with the ingestion of more than 13 kg of mitotane. <h3>Report of a Case</h3> A 49-year-old woman was admitted to a hospital in November 1967 with hirsutism and masses in the left breast and abdomen. Roentgenograms disclosed metastases in the ribs and liver and downward displacement of the left kidney. Two 24-hour urine collections

Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy

Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy

Metastatic Adrenal Cortical Carcinoma: Biochemical Changes Accompanying Clinical Regression During Therapy with o,p'-DDD

Abstract A 7-year-old girl with a six-month history of increasing virilism, growth, and acne excreted supranormal amounts of urinary 17-ketosteroids (87.6 mg/24 h). ACTH stimulation and dexamethasone suppression studies indicated adrenal tumor. A large left adrenal carcinoma was removed. Metastases were not observed. Postoperatively, 24-h urinary ketosteroids remained supranormal (16 mg). Sudden fever, cough, and hemoptysis precipitated hospitalization 42 months later. Bilateral lung metastases, a mass in the right upper quadrant, virilism, advanced bone age, and supranormal 24-h urinary ketosteroids (166 mg) and hydroxysteroids (16 mg) were found. The patient received 240 g of o,p'-dichlorodiphenyl-dichloroethane (o,p'-DDD), whereupon the abdominal mass and lung lesions regressed and 24-h urinary ketosteroids and hydroxysteroids decreased. Since this treatment (which ended April, 1968) the patient has been maintained at home on 7.5 g o,p'-DDD/day and replacement therapy with 9-α-fluorohydrocortisone and cortisone acetate. Almost all signs and symptoms have disappeared and urinary steroids are normal.

Testosterone and Androstenedione Production Rates in Patients with Metastatic Adrenal Cortical Carcinoma

ABSTRACT Five women with functioning adrenal cortical carcinoma had increased testosterone blood production rates and plasma levels which ranged from high normal to 20 times normal. In a man with feminizing adrenal cortical carcinoma the plasma testosterone was low but the production rate was normal. The testosterone metabolic clearance rates were increased above normal in all 6 patients. In 3 with very large tumors the testosterone metabolic clearance rates were higher than previously observed in patients without neoplastic disease. It is postulated that the large tumors actively metabolized testosterone so as to increase its clearance from the blood compartment. In contrast to testosterone, both androstenedione plasma levels and production rates ranged from normal to very high but in only one patient was the metabolic clearance rate higher than normal. In one patient a major fraction of the plasma testosterone was derived from plasma androstenedione but in 2 others testosterone was either secreted or de...

EFFECT OF METOPIRONE IN A PATIENT WITH ADRENAL CORTICAL CARCINOMA.

ABSTRACT The effect of metopirone® (SU-4885)* in a patient with metastatic adrenal cortical carcinoma was studied. The intention was to depress the symptoms of Cushing's syndrome, due to a high glucocorticoid production by the carcinoma. The excretion of 17-KS, 17-KGS, 11-oxo(y)-17-OHCS and 11-desoxy-17-OHCS was followed for seven weeks. The steroid excretion was variable. The 11-oxo(y)-17-OHCS showed a significant decrease during treatment with SU-4885 for seven weeks. The ratio 11-oxo(y)-17-OHCS: 11-desoxy-17-OHCS fell from 1.7 to 0.1 during this period. The excessive glucocorticoid production of the metastatic adrenal carcinoma was suppressed as long as treatment continued. It was not possible to judge the clinical effect of SU-4885 because of the progressive nature of the disease.