Introduction. The metallurgical enterprises of the city of Lipetsk are city-forming and provide the main anthropotechnogenic burden on the health of the population. The priority of preserving the health of the population determines the importance of studying the determinants of the environment on the health of the population and creates conditions for the organization of scientific research, which are aimed at developing scientifically based recommendations to reduce this process. The purpose of the study is to identify the features of the formation of the prevalence of non-communicable diseases in an industrial centre with a developed metallurgical industry. Material and methods. We used the data of the regional information fund concerning the state of the human environment and public health, the materials of the consolidated volume of maximum permissible emissions (MAE) of the city of Lipetsk, and statistical data. The comparative non-carcinogenic hazard indices and the assessment of mass non-communicable morbidity thresholds were calculated. Results. The analysis showed that as a result of the implementation of environmental measures at the city’s enterprises, there was a significant decrease in the level of atmospheric pollution. Positive changes in the habitat state are confirmed by the incidence rate for individual nosological units. A conjugated analysis of the indices of comparative non-carcinogenic hazard and morbidity made it possible to establish a threshold for mass non-infectious morbidity by nosology for the adult population and children. Discussion. The incidence rate has also dropped significantly. The improved quality of atmospheric air has erased the apparent dependence of the level and structure of morbidity from the impact of metallurgical production alone. Conclusion. Despite the decrease in emissions from stationary sources due to technological re-equipment, the implementation of environmental measures, and the incidence of many nosologies, many problems remain unsolved.