The chiroptical response of most naturally occurring chiral materials is generally very weak, which discourages further studies and limits applications. Recently, chiral plasmonic structures have received significant attention because of their large chiroptical response. Note that the interaction between the constituents is extremely important and indispensable to the chiroptical response in a chiral plasmonic system. Here, we extend the study of chiroptical response concerning the interaction between the constituents to a strong plasmon coupling regime based on the dimer of twisted metal nanorods. To this end, we realize the fabrication of twisted nanorods with a small gap size of ∼15 nm to ensure that we can observe the separated hybridized modes generated by the plasmon coupling between the twisted nanorods. The dependence of the plasmon coupling and dissymmetry factor on the gap size and twisted angle clearly demonstrates that the plasmon coupling followed by the hybridization strongly enhances the chiroptical response. The dissymmetry factor of the experimentally optimized structures reached values of up to ∼1.03, which is much larger than other nano-plasmonic systems of the same order of dimension. Furthermore, the chiroptical response, as well as the plasmon coupling, is very sensitive to the configuration of the structure, which means that they are precisely controlled by tuning the gap size and twisted angle. Our study that is based on the plasmon coupling provides a further understanding of the study of chiroptical response and will assist in the future design and improvement of chiral plasmonic structures for metamaterial applications.