Metal Incorporation Research Articles

Green synthesis and applications of mono/bimetallic nanoparticles on mesoporous clay: a review

Abstract Green nanotechnology comprises the use of natural sources such as plant extracts as both reducing and stabilizing agents thereby reducing the reliance on hazardous chemicals. Recent breakthroughs in nanotechnology involve the incorporation of various metals to create mono and bimetallic nanoparticles, catalyzing transformative shifts. However, concerns arise due to the environmental impact of traditional synthesis methods. An alternative approach focuses on biosynthesized metal nanoparticles using clay, specifically Bentonite, MMT (Montmorillonite) and Kaolinite as supportive materials, emphasizing the prevention of agglomeration with clay and the use of plant extracts. The integration of clay, especially Bentonite, MMT and Kaolinite enhances the stability and functionality. The review emphasizes mitigating environmental impact by reducing metal ions and explores the use of phytochemicals fro environmentally friendly nanoparticle synthesis. Incorporating clay minerals not only improves synthesis efficiency but also minimizes the ecological footprint. Future research is expected to focus on integrative approaches in plant nanotechnology, particularly in agriculture and broader plant science. The comprehensive review covers literature from 2015 to 2023, providing systematic and interpretative data, highlighting progress and potential in eco-friendly metal nanoparticles synthesis supported on clay minerals.

Production of monocyclic aromatic hydrocarbons by the catalytic pyrolysis of Moso bamboo at different ages and parts using Zn and Cr modified zeolite catalysts

Monocyclic aromatic hydrocarbons (MAHs) are important organic building blocks for the chemical industry, which can be produced by catalytic pyrolysis of biomass. The wide application of bamboo in Chinese industry generates a large amount of bamboo waste which can be utilized as the feedstock to produce MAHs. This study aimed to investigate the effect of bamboo age and bamboo part on the yield of the aromatics by using the Cr and Zn modified HZSM-5 as catalyst. The result showed that the incorporation of metals (Cr and Zn) enhanced the catalytic performance, and the incorporation of Zn was better than Cr. The highest MAHs content (38.67%) and total aromatic content (57.42%) were obtained with the catalyst of 3% Zn/HZSM-5 catalyst at temperature of 400 °C and duration time of 30 min. Younger age (1-year-old bamboo) and the outer skin of bamboo was better for the production of MAHs. This study provided a high value-added application approach for the waste Moso bamboo.

Tailoring Electrochemical Water Oxidation Activity from the Isostructural Series of Alkaline‐Stable Bimetallic Fe,Ni‐Azolate Metal–Organic Frameworks

AbstractIncorporating electrocatalytic active sites into the reticular framework allows for the design of novel catalytic structures promoting desired catalytic reactions with efficient mass transfer. However, to fully exploit the advantages of such a framework, it is crucial to ensure the electrochemical stability of the material. In this context, alkaline‐stable bimetallic MxNi2‐xCl2BTDD (M = Fe, Co) metal–organic frameworks (MOFs) are employed as electrocatalysts for alkaline water oxidation reaction (WOR) to understand the correlation between secondary metal incorporation and catalytic activity changes. For a specific Fe ratio within the MOF, the optimal catalytic activity is achieved at an overpotential of 315 mV at a WOR current density of 10 mA cm−2geo. Based on its well‐defined crystal structure and uniformly arranged metal nodes, which are not limited to specific facets, the cooperative electrocatalytic mechanism during the faradaic WOR process is investigated through operando Raman spectroscopy and density functional theory calculations. These results enable the interpretation of the electrochemical WOR mechanism based on MOF, providing a further fundamental understanding of electrocatalytic activity in bimetallic systems.

Effect of Sm dopant on electrocatalytic activity of AgNbO3 perovskite fabricated by sonication method for Oxygen Evaluation Reaction (OER)

Excessive reliance on fossil fuels causes a variety of difficulties and the use of efficient electrocatalysts material has exhibited significant attention for high electrocatalytic activity. Most transition metal oxide materials performance can be enhanced by the incorporation of metals for OER activity. This work presents the synthesis of samarium (Sm) doped silver niobium oxide (AgNbO3) was achieved using sonication techniques. An electrocatalyst, Sm-doped AgNbO3, has shown promising results for oxygen evolution reaction (OER) in alkaline medium with a significant increase in active sites, enhanced electrical conductivity and improved stability. The Sm-doped AgNbO3 electrocatalyst exhibits overpotential of 203 mV and Tafel slope of 35.22 mV dec−1 for OER activity at current densities of 10 mA cm−2. By utilizing, electrochemical surface area (ECSA), the Sm-doped AgNbO3 electrocatalyst exhibited higher ECSA values of 1009 cm−2 with a higher roughness factor of 2008.60. Further, observations of low charge transfer resistance value (Rct = 0.17 Ω) along with a durability of 50 h, indicate that this material is highly efficient and long-lasting as an electrocatalyst for energy conversion systems.

Polymer-Supported Heterogeneous Fenton Catalysts for the Environmental Remediation of Wastewater.

Materials based on polymer hydrogels have demonstrated potential as innovative Fenton catalysts for treating water. However, developing these polymer-supported catalysts with robust stability presents a significant challenge. This paper explores the development and application of polymer-supported heterogeneous Fenton catalysts for the environmental remediation of wastewater, emphasizing the enhancement of metal incorporation into catalysts for improved efficiency. The study begins with an introduction to the heterogeneous Fenton process and its relevance to wastewater treatment. It further delves into the specifics of polymer-supported heterogeneous Fenton catalysts, focusing on iron oxide, copper complexes/nanoparticles, and ruthenium as key components. The synthesis methods employed to prepare these catalysts are discussed, highlighting the innovative approaches to achieve substantial metal incorporation. Operational parameters such as catalyst dosage, pollutant concentration, and the effect of pH on the process efficiency are thoroughly examined. The catalytic performance is evaluated, providing insights into the effectiveness of these catalysts in degrading pollutants. Recent developments in the field are reviewed, showcasing advancements in catalyst design and application. The study also addresses the stability and reusability of polymer-supported heterogeneous Fenton catalysts, critical factors for their practical application in environmental remediation. Environmental applications are explored, demonstrating the potential of these catalysts in addressing various pollutants. The Conclusions offers future perspectives, underlining the ongoing challenges and opportunities in the field, and the importance of further research to enhance the efficacy and sustainability of polymer-supported heterogeneous Fenton catalysts for wastewater treatment.

Enhanced photocatalytic hydrogen generation using UiO-66(Zr) MOF with tailored modifications: A review

The utilization of UiO-66 MOF-based photocatalytic materials has achieved significant attention for their potential in hydrogen generation, owing to their remarkable stability and porous crystalline structure. Recent studies have disclosed enhanced light absorption capabilities in UiO-66 through both pre and post-synthetic modifications. These modifications also play a significant role in mitigating the recombination of photogenerated charge carriers by facilitating electron transfer in hybrid or derived materials. Designing of MOF-based modified improved photocatalyst includes, integration with other low band gap semiconductors, incorporation of noble metals as co-catalysts, surface engineering, inclusion of defects or introduction of heteroatom in the framework. MOF-COF hybridization, dye sensitization etc., further reinforced photocatalytic hydrogen yield. The above-mentioned comprehensive investigations have researched into aspects such as morphology, hydrogen generation efficiency, and the underlying mechanisms. It reveals that the creation of heterojunctions at interface channelizes the separation and smooth flow of electrons resulting in suppression of recombination reaction and favorable photocatalytic properties. The synergy between the components often results in enhanced performance. The present article provides a comprehensive review of modified UiO-66 MOF-based materials investigated for photocatalytic hydrogen generation.

Facile synthesis of flower-like NiCo/NiO–CoO surrounded by N-doped porous carbon derived from covalent organic framework for aqueous asymmetric supercapacitor

The persisting quest for improving charge density, electronic conductivity and cyclic stability of the electrode material in supercapacitor (SC) applications still demands intensive research and advancements. This study also aims the aforementioned pursuit with the construction of hybrid supercapacitor using mixed metal oxides with the incorporation of metal and supported with porous carbon to improve the charge density, electrical conductivity and cyclic stability, respectively. A covalent organic framework (COF) was synthesized and doped with nickel (Ni2+) and cobalt (Co2+) ions followed by carbonization at 1000 °C for 3 h to generate NiCo/NiO–CoO surrounded N-doped porous carbon (NPC) framework. The X-ray diffraction reveals that nickel considerably impacts the crystallinity of NiCo/NiO–CoO and the Raman spectroscopy revealed that the NiCo/NiO-CoO-NPC with an equal molar ratio of Ni2+ and Co2+ ions (NiCo/NiO-CoO-NPC-2) offered the highest degree of graphitization. The electron microscopic images showed the formation of flower-like morphology of NiCo/NiO-CoO-NPC-2 with a size of 250 nm and the greater number of flowers on NPC's surface could augment the electrochemical activity of the composite material. The NiCo/NiO–CoO-NPC-2 offered an attractive specific capacitance (Cs) of 845 F g−1 @ 1 A g−1 and preserves 93% capacity retention @ 10 A g−1 after 6000 charge-discharge cycles while exploited in SC application. The metal-free COF carbonized at 900 °C (CCOF-900) is utilized as the negative electrode with a Cs of 286 F g−1 @ 1 A g−1 for the construction of an asymmetric supercapacitor device and the NiCo/NiO-CoO-NPC-2//CCOF-900 device delivered efficient energy of 54 Wh kg−1 at a power density of 633 W kg−1.

Degradation of levofloxacin using electro coagulation residuals-alginate beads as a novel heterogeneous electro-fenton composite

The presence of levofloxacin (LEV) in aqueous solutions can pose health risks to humans, have adverse effects on aquatic organisms and ecosystems, and contribute to the development of antibiotic-resistant bacteria. This study aims to investigate the feasibility of using electrocoagulation residuals (ECRs) as a heterogeneous catalyst in the electro-Fenton process for degrading LEV. By combining electrocoagulation residuals with sodium alginate, ECRs-alginate beads were synthesized as a heterogeneous electro-Fenton composite. The response surface method was employed to investigate the optimization and influence of various operating parameters such as the initial concentration of LEV (10–50 mg/L), voltage (15–35 V), pH (3–9), and catalyst dose (1–9 g/L). The successful incorporation of iron and other metals into the ECRs-alginate beads was confirmed by characterization tests such as EDX and FTIR. By conducting a batch reaction under optimal conditions (initial LEV concentration = 20 mg/L, pH = 4.5, voltage = 30V, and catalyst dose = 7 g/L), a remarkable degradation of 99% for LEV was achieved. Additionally, under these optimal conditions, a high removal efficiency of 92.3% for total organic carbon (TOC) could be attained within 120 min and these findings are remarkable compared to previous studies. The results further indicated that the degradation of levofloxacin (LEV) could be accurately quantified by utilizing the first-order kinetic reaction with a 0.03 min−1 rate constant. The synthesized beads offered notable advantages in terms of being eco-friendly, simple to use, highly efficient, and easily recoverable from the liquid medium after use.

Highly Exothermic and Fast Mechanochemical Redox and Intercalation Reactions of V2O5 with Sodium Hydride.

Vanadium oxides exhibit promising characteristics for electrochemical energy storage, owing to their capability to switch between different oxidation states, in combination with the incorporation of alkali metals. Here, we report on a systematic investigation of the mechanochemical reduction of V2O5 with NaH. In contrast to conventional high-temperature synthesis methods, the mechanochemical reaction occurs already after a few minutes. We observed a mixture of different (sodium) vanadium oxides with vanadium oxidation states ranging from +III to +V. Remarkably, these highly exothermic self-propagating reactions occur even within a rudimentary pistil-mortar setup. Hereby, the hydride concentration has a greater effect on the final sample composition than the milling time. In general, higher percentages of sodium vanadates are formed instead of vanadium oxides, and the lower oxidation states of vanadium are accessible with increasing amounts of NaH. Theoretical calculations confirm these experimental observations and emphasize the central role of sodium vanadates, especially with vanadium in the +V oxidation state, in carrying out the observed exothermic reactions. This comprehensive study sheds light on the mechanochemical reduction of vanadium oxides and underlines their potential for further development of electrochemical energy storage systems.

Enhanced hydrogen adsorption-desorption reversibility found on NiAl alloy: A first-principles study

Improving the hydrogen storage performance of carbon-based materials via transition metals incorporation has been proved experimentally, where control over the hydrogen adsorption kinetics and hydrogen surface diffusion is the key. In this work, we proved theoretically via density functional theory (DFT) how such incorporation promotes better hydrogen storage performance in Ni-based materials supported on graphene, in which static and dynamic behavior of the system were modeled by plane-wave DFT and ab initio molecular dynamics (AIMD), respectively. In addition, the hydrogen storage materials Ni10Al3 and Ni13 supported on graphene, denoted as Ni10Al3/GP and Ni13/GP, are modeled to realize the experimental observation on Ni3Al alloy under high hydrogen pressure. It was found that the Ni10Al3/GP alloy system exhibited better properties in twofold: (1) increased hydrogen adsorption capacity through providing an additional site for H2 molecular adsorption, particularly on the Al atoms, and (2) enhanced hydrogen desorption at ambient conditions observed from reversible H2 adsorption at all coverages with barrierless migration energy. Therefore, the proof from the DFT point-of-view provides valuable insight into exploring other metal alloy systems that can provide additional sites for molecular hydrogen adsorption and improve hydrogen adsorbate mobility.

Study of the optoelectronic properties and the doping effect on different atoms of the CsSnBr3 supercell to absorb visible light: First-principles calculations

Lead-free halide perovskites are prototype materials-based solar cells and many other devices optoelectronic, that have exhibited high power conversion efficiencies, high absorption, and the most important thing is environmentally friendly. This paper presents detailed ab initio calculations of the structural, electronic and optical properties of inorganic perovskite CsSnBr3 by using the density functional theory (DFT) and the time-dependent density functional theory (TDDFT). The main objective of this work is to investigate the effects of Mn doped on the optoelectronic properties of CsSnBr3 supercell such as we have substituted the Cs atoms (Cs1−xMnxSnBr3) and Sn atoms (CsSn1−xMnxBr3) respectively by Mn transition metal atoms. The results show that the incorporation of Mn metal in the studied compound improves significantly the optoelectronic properties such that the band gap of CsSnBr3 is 0.546 eV becomes 0.208 eV after doping. The case of the doped samples are the more suitable choice for optoelectronic devices due to the high dielectric constant and a small gap energy, which shows a low recombination rate, and consequently, improves the device performance especially in the visible energy range (1.65–3.26 eV).

Evaluation of photocatalysis inactivation in indoor air purification of pathogenic microbes by using the different nanomaterials based on TiO2 nanomaterials

The photocatalytic technology for indoor air disinfection has been broadly studied in the last decade. Selecting proper photocatalysts with high disinfection efficiency remains to be a challenge. By doping with the incorporation of metals, the bandgap can be narrowed while avoiding the recombination of photogenerated charge. Three photocatalysts (Ag-TiO2, MnO2-TiO2, and MnS2-TiO2) were tested in photocatalytic sterilization process. The results revealed that Ag-TiO2 had the best antibacterial performance. Within 20 min, the concentration of Serratia marcescens (the tested bacteria) decreased log number of ln 4.04 under 640 w/m2 light intensity with 1000 µg/mL of Ag-TiO2. During the process of inactivating bacteria, the cell membranes of bacterial was destructed and thus decreasing the activity of enzymes and releasing the cell contents, due to the generation of reactive oxygen species (O2•– and •OH) and thermal effect. Spectral regulation has the greatest impact on the sterilization efficiency of MnO2-TiO2, which reduces the probability of photocatalytic materials being excited.

Enhanced visible-light-active MOF-based PbO photocatalyst for binary dye decolorization: A comprehensive study

Developing efficient and sustainable wastewater treatment technologies like photocatalysis is essential to combating global water pollution. Despite lead oxide's photocatalytic potential, its high recombination rate and low active sites restrict its application. In the current study, the first MOF-based PbO nanostructure has been successfully synthesized in a facile way. The as-synthesized sample, PbO/Aluminum fumarate metal–organic framework (PbO/AlFu), was characterized in multiple manners and applied to degrade mixtures of methyl green (MeG) and crystal violet (CV) dyes under visible light irradiation. The incorporation of AlFu metal–organic framework as a support for PbO significantly enhanced photo-degradation performance. This enhancement can be attributed to the increased visible light harvesting, adsorption capabilities facilitated by AlFu, and separation of photo-generated electron-hole pairs due to the formation of the step-scheme (S-scheme) heterojunction. Photocatalytic efficiencies and operational parameters were modeled and optimized respectively using the Box-Behnken design (BBD). Under optimized conditions, MeG and CV dyes were removed at 95.6 and 86.1 percent, respectively. •O2– and •OH radicals were identified as key contributors to the photo-degradation of both dyes. Kinetic studies revealed that photo-degradation of both dyes followed the Langmuir-Hinshelwood model, suggesting a surface-mediated reaction mechanism. PbO/AlFu demonstrated outstanding stability and reusability in five sequential photo-degradation cycles. The present findings highlight the potential of PbO/AlFu as a promising photocatalyst for wastewater treatment.

Potential Applications of Metal‐Doped Nanomaterials for Enhancing Solid‐State Hydrogen Storage

AbstractHydrogen energy is the primary replacement for fossil fuels in the future because of its advantages in terms of efficiency, cost‐effectiveness, and environmental friendliness. The fundamental issue with hydrogen, however, arises from its exceedingly low volumetric density; thus, developing efficient storage methods is critical to achieving a sustainable hydrogen economy. Hydrogen storage has demonstrated tremendous potential as a possible alternative for effective large‐scale storage. Due to their low cost, and high volumetric and gravimetric capacities, metal hydride‐based storage is considered the most prospective solid‐state storage material. Their low storage capacity nevertheless restricts their application effectively. Hence, the need to enhance the storage capacity by doping active metals becomes an interesting study area. With considerable success, metals, particularly transition metals, have been used to modify hydrides to improve their storage capacities. Owing to their strong and superior performance, active metals have demonstrated tremendous potential in increasing the performance of storage materials. This review critically examined recent developments in enhancing hydrogen storage characteristics through the incorporation of active metals. The preparation techniques for metal infiltration through different techniques, such as impregnation, ball/mechanical milling, and reflux were reported. The review describes significant advances in hydrogen storage characteristics due to metal doping and offers perspective recommendations for future research.

Regulating Phase Transition and Restraining Fe Distortion at High Potential Window via Rare Earth Metal Incorporation on O3‐Type Layered Cathodes

AbstractRapid capacity fading and structural collapse, along with other deep‐rooted challenges in the high‐voltage region, are insufficient to meet the requirements for commercial applications of O3‐type layered cathodes. Hereby, rare earth metal (RE) within the IIIB group are utilized as the robust dopants for O3‐NaNi1/3Fe1/3Mn1/3O2 (NFM) to achieve the purpose of reconstructing the crystal lattice and regulating the interlayer structure. The inactive RE3+ acts as a pillar, reinforces the TMO6 octahedron, and broadens the Na+ diffusion layer in the configuration of O‐Na‐O‐TM (RE)‐O‐Na‐O, giving rise to the enhanced crystal stability and accelerating the transmission of sodium ions. More impressively, the scandium incorporation is working as a “vitamin” that improves Ni/Fe redox reversibility, alleviating the irreversible P3‐O3’‐P3’ phase transformation and further restraining the disordered Fe migration into the neighboring Na layer, which is firmly validated by in situ X‐ray diffraction coupled with the synchrotron X‐ray absorption spectroscopy. Consequently, the as‐designed NFM‐Sc exhibits impressive rate capability (82.5 mAh g−1 at 10 C) and excellent cycle stability with 80.2% capacity retention after 500 cycles at the high voltage of 4.2 V. Given this, the elaborate work may shed new insight into the operational mechanism of rare metal through strategically regulating the structure for sodium‐ion batteries.

Robust Room Temperature Thermoelectric Performance of Mg3(Sb, Bi)2‐Based Alloys via Multivalent Mn Doping

Abstractn‐type Mg3(Sb, Bi)2 has excellent room temperature thermoelectric performance, which is, however, severely restricted by the negatively charged Mg vacancies that significantly deteriorate the carrier mobility. Herein, by manipulating the threshold solubility and defect formation energy of Mn, multivalent Mn is selectively introduced that synergistically promotes the carrier conduction according to different Mg chemical potentials; In Mg‐rich areas, interstitial Mn dominates which effectively reduces the migration and accumulation of Mg vacancies, while in Mg poor areas, interstitial Mn switches to substitutional sites that directly compensate for the negative charge. All the Mn centers possess Jahn–Teller inactive positions, leading to an ultra‐stable room temperature thermoelectric performance with a leading ZT up to 0.97. This work reveals the critical effect of multivalent and multifunctional transition metal incorporation in Mg3(Sb, Bi)2‐based alloys toward high room‐temperature thermoelectric performance.

A incorporation of metal into worm-like mesoporous silica materials for selective adsorption of MB in dyestuff

Worm-like mesoporous silica was synthesized using hydroxyethyl cellulose (HEC) as the template agent and sodium metasilicate as the silicon source (hereinafter referred to as HECMS). Different types of metal-doped adsorbents (namely Zr-HECMS-P, Fe-HECMS-P, and Al-HECMS-P) were prepared using the post-grafting method. The three adsorbents were used for the selective adsorption of methylene blue (MB) from an MB/methylene orange (MO) solution. Results showed that under acidic conditions, Fe-HECMS-P exhibited simultaneous adsorption of MB and MO, whereas Zr-HECMS-P and Al-HECMS-P preferably adsorbed MB. Zr-HECMS was determined to be the best adsorbent based on the evaluation results of the selective-adsorption effect of MB in different adsorption environments. Furthermore, different zirconium-silicon molar ratio samples were synthesized (The name is designated as Zr(0.01)-HECMS-P, Zr(0.02)-HECMS-P and Zr(0.04)-HECMS-P.). Results revealed that at pH = 3 and an initial MB concentration of 25 mg/L, Zr(0.01)-HECMS-P exhibited the best selective-adsorption performance for MB, reaching adsorption equilibrium in 2 h with a maximum removal rate of 97.8 %. The adsorption process followed a pseudo-second-order model, and the adsorption mechanism involved coordination and electrostatic action. In a simple binary system (MB + MO), the Zr(0.01)-HECMS-P adsorbent exhibited good selectivity for the MB dye. Finally, after five cycles of regeneration, the adsorption performance of Zr(0.01)-HECMS-P remains stable.

Structure–Activity Relationship and Stimuli-Responsiveness Behavior of Metallosupramolecular Polymers

The widespread discourse on the circular economy has fueled a growing demand for polymeric materials characterized by mechanical robustness, sustainability, renewability, and the ability to mend defects. Such materials can be crafted using dynamic covalent bonds, albeit rarely or more efficiently through noncovalent interactions. Metal–ligand interactions, commonly employed by living organisms to adapt to environmental changes, play a pivotal role in this endeavor. Metallosupramolecular polymers (MSPs), formed through the incorporation of metal–ligand interactions, present a versatile platform for tailoring physicochemical properties. This review explores recent advancements in MSPs achieved through the assembly of (macro)monomers via reversible metal–ligand interactions. Various strategies and pathways for synthesizing these materials are discussed, along with their resulting properties. The review delves into the stimuli-responsive behavior of coordination metal–ligand polymers, shedding light on the impact of the core employed in MSPs. Additionally, it examines the influence of parameters such as solvent choice and counter-ions on the supramolecular assemblies. The ability of these materials to adapt their properties in response to changing environmental conditions challenges the traditional goal of creating stable materials, marking a paradigm shift in material design.

Theoretical exploration of ternary nitrides for high-efficiency ferroelectric photovoltaics

Although nitride materials hold great functional promise, ferroelectric photovoltaic nitrides remain relatively rare within the scientific community. In this study, high-throughput calculations have been employed to explore and predict novel stable ternary nitrides characterized by both high photoelectric conversion efficiency and robust ferroelectric polarization. Notable candidates, including Mg2CrN3, Mg2MnN3, MgVN2, ZnVN2, and X2BiN3 (where X represents Mg, Ca, and Sr), are anticipated to exhibit remarkable ferroelectric photovoltaic properties, with a particular emphasis on efficiently harnessing visible light. The incorporation of early 3d transition metals and bismuth (Bi) elements within ternary metal nitrides is highlighted as a key strategy for achieving high ferroelectric photovoltaic efficiency. Furthermore, these ferroelectric nitrides demonstrate relatively high carrier mobilities, which are conducive to facilitating the transport of photogenerated carriers driven by ferroelectricity. This research offers a selection of promising ternary nitride candidates with substantial potential for application in the field of ferroelectric photovoltaics.

Nitroprusside and metal nitroprusside nano analogues for cancer therapy.

Sodium nitroprusside (SNP), U.S approved drug has been used in clinical emergency as a hypertensive drug for more than a decade. It is well established for its various biomedical applications such as angiogenesis, wound healing, neurological disorders including anti-microbial applications etc. Apart from that, SNP have been considered as excellent biomedical materials for its use as anti-cancer agent because of its behavior as NO-donor. Recent reports suggest that incorporation of metals in SNP/encapsulation of SNP in metal nanoparticles (metal nitroprusside analogues) shows better therapeutic anti-cancer activity. Although there are numerous reports available regarding the biological applications of SNP and metal-based SNP analogue nanoparticles, unfortunately there is not a single comprehensive review which highlights the anti-cancer activity of SNP and its derivative metal analogues in detail along with the future perspective. To this end, the present review article focuses the recent development of anti-cancer activity of SNP and metal-based SNP analogues, their plausible mechanism of action, current status. Furthermore, the future perspectives and challenges of these biomedical materials are also discussed. Overall, this review article represents a new perspective in the area of cancer nanomedicine that will attract a wider spectrum of scientific community.