The phytoremediation is a significant natural clean-up process for removal of heavy metals from wetland saline soils (WS) for the sustainable environmental pollution control. Therefore, the phytoremediation potential of Typha domingensis (southern cattail) and Phragmites australis (common reed) has been evaluated for absorption and accumulation of salts and heavy metals growing at two sites of WS samples coded as BS1 and BS2 (“BS” the soil that is not adjoining to root of plants) in Hyderabad Sindh, Pakistan. The three parts (root, stems, and leaves) of both Plants were obtained from several of locations oxidized the matrices of each part of plants and the corresponding soil samples using acid mixture. A variety of techniques were used to identify the metals by atomic absorption spectrometry. The average values of heavy metals, Co, Cd, Cr, Cu, Pb, and Zn in BS1 and BS2 were found to be (8.53, 14.4, 8.88, 64.3, 13.3, and 142) and (12.4, 18.2, 13.6, 89.4, 14.4, and 124) µg/g, respectively. The data of bioconcentration (BCF) and translocation factors (TF) of the research showed that the studied halophytes showed a high accumulation potential (> 1) for heavy metals from WS. The metal content in plants and rhizospheric soil have a strong relationship (p < 0.01). The screening data based on classical methods and GC–MS indicated that the studied phyto extractants have many phytochemicals. These phytochemicals may have the capability to accumulate heavy metals from contaminated soils. The roots and their rhizospheric soil (RS1 and RS2) have a highly significant relationship of accumulation potential with the selected heavy metals (RS is soil adjoining to roots of plants) (p < 0.01). These halophytes are able to remove heavy metals directly from salty metal-contaminated soil in wetland environments.