Metal Complexes Of Derivatives Research Articles

Synthesis, spectral, antioxidant, in vitro cytotoxicity activity and thermal analysis of Schiff base metal complexes with 2,2′-Bipyridine-4,4′-dicarboxylic acid as co-ligand

The Schiff base ligand (H2L1) [H2L1 = (E)-2-hydroxy-N'-((2-hydroxynaphthalen-1-yl)-methylene) benzo hydrazide] and its metal (II) complexes of molecular formula [Co(H2L1)(L2)], [Ni(H2L1)(L2)], [Cu(H2L1)(L2)], [Zn(H2L1)(L2)], [Cd(H2L1)(L2)], where, L2 = 2,2′-Bipyridine-4,4′-dicarboxylic acid as co ligand were synthesized and characterised using various analytical techniques. Based on spectral analysis, the complexes are found to be square pyramidal and also the coordinating sites of the complexes are azomethine nitrogen, two phenolic oxygen from Schiff base ligand (H2L1) and two nitrogen from 2,2′-Bipyridine-4,4′-dicarboxylic acid. The antimicrobial activity of the ligand and complexes was determined by testing them against bacterial pathogens and fungal strains. All the synthesized complexes were more active than the free chelate against the tested microorganisms. According to our findings, the antioxidant activity of complexes by the DPPH method is concentration-dependant and better than the free ligand H2L1. Compared to the therapeutically utilised Sorafenib (Nexavar), the metal complexes and its H2L1 ligand displayed stronger cytotoxicity against the human breast cancer MCF -7 cell lines. The [Co(H2L1)(L2)] complex showed promising anticancer activity with IC50 3.5 μg/mL. Cell death is due to apoptosis in MCF-7 cells and the formation of ROS by the Schiff base ligand H2L1 and its derived metal complexes.

A Short Review: Chemistry of Curcumin and Its Metal Complex Derivatives

This review covers recent progress in the synthesis of curcumin and the bioactivity of semisynthetic and synthetic analogs of curcumin. The review also shows how curcumin is a useful intermediate for the synthesis of more complex organic molecules; historical perspective; the process of preparing the metal complexes and characterization the produced complexes using various spectral and other techniques; shows the importance of curcumin and its derivatives for their potential applications in medical devices and broad-spectrum of medical application such as antibiotic ointment, alternative therapeutics, antifungal, and antibacterial activities.

Review article-Amalgamation, scrutinizing, and biological evaluation of the antimicrobial aptitude of thiosemicarbazide Schiff bases derivatives metal complexes

The initial report, there has been a tremendous development of Schiff base ligands and their metal complexes which Since have captured the attention of researchers owing to an increasing number of applications of these compounds to a variety of fields. Thiosemicarbazones owing to their unique characteristics including multiple bonding modes, application as bioinorganic processes because of N, O, and S as donor atoms, excellent complexing ability, and broad-spectrum biological activities with minimum toxicity owing to –N-C = S moiety. The Schiff bases ligands have structural similarities with natural biological systems that’s why metal complexes of Schiff bases derivatives have been applied for catalytic activities and biological studies. Literature supported the practical employment of Schiff bases metal complexes in the area of material science to biological sciences Therefore, the review summarized the amalgamation, scrutinizing and substantiating the antimicrobial aptitude of thiosemicarbazide derivatives of Schiff Bases metal complexes.

Amalgamation and Scrutinizing of Leucine Derivatives Schiff Bases Complexes as Antimicrobial Agent.

The enhanced applications of Schiff bases metal complexes of amino acid derivatives have captured the attention of researchers for the synthesis of leucine derivatives of Schiff bases metal complexes. Amino acids are considered to be essential part of food supplements as well as derivatives of Schiff bases in coordination chemistry due to their donor ability. The leucine derivatives Schiff bases ligand have been synthesized by condensation reaction between amine of leucine with aldehyde or ketone bearing molecules attached with them. These complexes were characterized by different spectroscopic tools in order to confirm their structural geometries. The structural geometries are considered to be very important in order to improve the antimicrobial potential of leucine derivative metal complexes. By taking into account the antimicrobial potential of titled compounds, a comprehensive review of leucine derivatives of Schiff bases metal complexes has been compiled.

Octakis(Carboxyalkyl-Thioethyl)Silsesquioxanes and Derived Metal Complexes: Synthesis, Characterization and Catalytic Activity Assessments

Octakis(Carboxyalkyl-Thioethyl)Silsesquioxanes and Derived Metal Complexes: Synthesis, Characterization and Catalytic Activity Assessments

Novel polymeric metal complexes of salicylaldehyde schiff base derivative being used for dye sensitizer

For studying the effect of metal complexes used as auxiliary electron acceptors of dye sensitizers in dye sensitized solar cell (DSSC) on photovoltaic performance, four polymeric metal complexes, which adopt 1,4-dioctyloxy-2,5-dibromobenzene or thienylbenzo-[1,2-b:4,5-b']-dithiophene (BDTT) as electron donor (D), salicylaldehyde schiff base derivatives as auxiliary acceptor (A), 8-hydroxyquinoline derivative as π bridge and acceptor (A), were designed, synthesized and characterized. The influence of different donor and metal complexes of the four dye sensitizers on performance were discussed by determining their thermal, photophysical, electrochemical and photovoltaic properties. The DSSC devices based on the four polymeric metal complexes PBDTT–SF–Cd, PBDTT–SF–Cu, PPV-SF-Cd and PPV-SF-Cu exhibited a short-circuit photocurrent density (Jsc) of 14.94 mA cm−2, 14.86 mA cm−2, 10.23 mA cm−2 and 9.80 mA cm−2 as well as acquired power conversion efficiency (PCE) of 8.59%, 8.45%, 5.29% and 4.77% respectively under the AM 1.5 irradiation (100 mW cm−2). Both Jsc and PCE value of the four polymeric metal complexes are in a decreased order. The phenomenon is attributed to not only the variable strength of coordination bond formed between metal ion and ligand, which can be affected by the radius and charge number of metal ion, but also the better electron-donating ability of BDTT. In common charge number, bigger radius of metal ion will cause more powerful coordination bond as well as greater electron-withdrawing ability of auxiliary acceptor and charge-transfer ability between donor and acceptor. This work provides a distinctive perspective for the design of D-A-π-A motif complexes in DSSC application.

Synthesis and Characterization Some Transition Metal Complexes of New Ligand Chalcone-Azo Derivatives from P-methoxy-4, 5-diphenyl Imidazole and Study Biological Effect of Pd(II) Complex

This paper explained synthesis of new ligand 1-(4-((4,5-bis (4-methoxy phenyl)-1H-imidazol-2-yl)diazenyl)phenyl)-3-(4-bromophenyl)prop-2-en-1-one (LBr), this ligand coordinates with (Co, Ni, Cu, Zn, Hg and Pd)(II) in mole ratio (1:2), the ligand characterized by numerous spectroscopic techniques such (UV-Visible, H-NMR, Mass, IR, C.H.N), while its complexes characterized by (UV-Visible, IR, C.H.N., electrical molar conductivity and magnetic susceptibility). The results of this study proposed an Octahedral geometry for all complexes excepting Pd(II) complex was square planer antitumor activity against breast cancer line (MCF-7) was gauged using Pd(II)complex, which has been shown selective cytotoxicity destroying cancer cells, this decides Pd(II) complex could be used to create anti-cancer medication in the forthcoming after compered between ligand has been prepared and this complex in cytotoxic effects.

Novel metal complexes of pyridineimine derivative used as auxiliary electron acceptor of D-(A-π-A)2 motif dye sensitizer: synthesis and photovoltaic application

Novel metal complexes of pyridineimine derivative used as auxiliary electron acceptor of D-(A-π-A)2 motif dye sensitizer: synthesis and photovoltaic application

Synthesis and anticancer activity of Pt(II) complexes of spiro-5-substituted 2,4-dithiohydantoins

Despite the widely studied anticancer activity of metal complexes of various hydantoin derivatives, reports on biological properties of dithiohydantoin complexes are limited to only few. Main challenge is determination of their structure, since no crystallographic data are available for metal complexes of dithiohydantoins. Herein, we describe the synthesis and structure of Pt(II) complexes of two spiro-5-(2,4-dihiohydantoins) with large and potentially intercalating aromatic rings, namely 3′,4′-dihydro-2H,2′H,5H-spiro[imidazolidine-4,1′-naphthalene]-2,5-dithione and spiro-(fluorene-9,4′-imidazolidine)-2′,5′-dithione. The anticancer activity of all compounds were tested against HL-60, BV-173, and K-562 tumor cell lines. Single-crystal X-ray analysis was performed for the spiro-(benzocyclohexane-4′-imidazolidine)-2′,5′-dithione, whereas all other compounds were characterized by integrated approach of spectroscopic (IR and solid-state NMR) and theoretical (DFT) studies. The analysis of the data suggested Pt2L4 composition of the complexes with bridging N^S coordination of four ligand molecules and two Pt(II) centers of square planar geometry. Polymeric structure in the solid state was also presumed. The complexes showed modest to moderate anticancer activity as compared to cisplatin and the chronic myeloid leukemia derived BV-173 proved to be the most responsive tumor model.

A Study on Camphor Derivatives and Its Applications: A Review

Natural compounds are the prominent sources for the synthesis of abundant biologically active substances in medicinal chemistry. Camphor exists in two enantiomeric forms i.e., R and S, or both, which are readily obtainable. Camphor is a small molecule with chirality property that binds to some active site, together with its low cost and convenience to transform into synthetically useful derivatives and one of the most important monoterpenoids widely spread in plants and has been used as starting material for the various camphor based derivatives which exhibit several biological activities include antimicrobial, antiviral, antioxidant, analgesic and anti-cancer. Many of those simple derivatives are commercially available in the form of camphor sulfonic acid or ketopinic acid that can be easily be produced from camphor. This compound is primarily used as a chiral starting material in the enantiospecific synthesis of natural products is because of its available methods for the direct or indirect introduction of functionality at C-3, C-5, C-8, C-9, and C-10 carbon atoms. In this study, heterocyclic compounds derived from camphor are arranged in different groups as Camphor-Derived Simple Heterocycles, Fused Camphor-Derived Heterocycles, Spiro Camphor-Derived Heterocycles, Ring Expanded Camphor-Derived Heterocycles and Camphor derived metal complexes. This study summarizes the transformations of camphor and its derivatives along with their biological activities.

Medicinal chemistry of anthranilic acid derivatives: A mini review.

Anthranilic acid and its analogues present a privileged profile as pharmacophores for the rational development of pharmaceuticals deliberated for managing the pathophysiology and pathogenesis of various diseases. The substitution on anthranilic acid scaffold provides large compound libraries, which enable a comprehensive assessment of the structure activity relationship (SAR) analysis for the identification of hits and leads in a typical drug development paradigm. Besides, their widespread applications as anti-inflammatory fenamates, the amide and anilide derivatives of anthranilic acid analogues play a central role in the management of several metabolic disorders. In addition, these derivatives of anthranilic acid exhibit interesting antimicrobial, antiviral and insecticidal properties, whereas the derivatives based on anthranilic diamide scaffold present applications as P-glycoprotein inhibitors for managing the drug resistance in cancer cells. In addition, the anthranilic acid derivatives serve as the inducers of apoptosis, inhibitors of hedgehog signaling pathway, inhibitors of mitogen activated protein kinase pathway, and the inhibitors of aldo-keto reductase enzymes. The antiviral derivatives of anthranilic acid focus on the inhibition of hepatitis C virus NS5B polymerase to manifest considerable antiviral properties. The anthranilic acid derivatives reportedly present neuroprotective applications by downregulating the key pathways responsible for the manifestation of neuropathological features and neurodegeneration. Nevertheless, the transition metal complexes of anthranilic acid derivatives offer therapeutic applications in diabetes mellitus, and obesity by regulating the activity of α-glucosidase. The present review demonstrates a critical analysis of the therapeutic profile of the key derivatives of anthranilic acid and its analogues for the rational development of pharmaceuticals and therapeutic molecules.

Control of Metal Content in Polystyrene Microbeads Prepared with Metal Complexes of DTPA Derivatives

Mass cytometry (MC) is an emerging analytical technique in which an inductively coupled plasma time-of-flight mass spectrometer is employed to analyze the signals of isotopic labels on cell and mic...

Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity

In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn(L)2(TsO)2]2DMF (1), {[Cd(L)(NO3)2H2O)]DMF}n (2) (where L = 4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectroscopic methods. In addition, the structure of the complexes (1 and 2) was confirmed by single-crystal X-ray analysis. Complex 1 has a discrete monomeric structure where L acts as a bidentate agent coordinating the zinc(II) atom through pyridine nitrogen and thiazole nitrogen, while complex 2 consists of polymeric {[Cd(L)(NO3)2H2O)]DMF}n chains in which cadmium(II) atoms are linked by the bridging ligand. The in vitro antimicrobial and antitumor activities of the ligand and complexes (1 and 2) were evaluated against seven pathogenic bacterial strains and four human cancer cell lines, and the results showed that some compounds had absolute specificity for certain bacterial strains or cancer cell lines, which thus implied a good application prospect in pharmaceutical use.

Synthesis, spectroscopic characterization, dyeing performance and corrosion inhibition study of transition metal complexes of a novel azo derivative formed from 2-aminothiophene

Abstract A novel bi-heterocyclic azo derivative is synthesized by the diazo-coupling reaction of 2-amino-3-carbethoxy-4,5-dimethylthiophene and 2-amino-4-phenylthiazole and its ligational behaviour towards Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) salts is investigated. The complexes are characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility measurements, UV-Visible, IR and 1H NMR spectral data. Spectral data have indicated that the ligand is coordinated to the metal ion in a neutral bidentate manner. On the basis of electronic spectral data and magnetic susceptibility measurements, suitable geometry is proposed for each complex. Thermogravimetric studies of copper(II) complex are used to characterize the complex. The dyeing performance of the azo derivative and its metal complexes is examined on silk fabric. The corrosion inhibition efficiency of the ligand and its metal complex in 0.5 M H2SO4 for mild steel coupons is monitored by weight-loss and open circuit potential measurements .

Concentration‐Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin**

Metal chelates targeted to amyloid peptides are widely explored as diagnostic tools or therapeutic agents. The attachment of a metal complex to amyloid recognition units typically leads to a decrease in peptide affinity. We show here that by separating a macrocyclic GdL chelate and a PiB targeting unit with a long hydrophobic C10 linker, it is possible to attain nanomolar affinities for both Aβ1-40 (Kd =4.4 nm) and amylin (Kd =4.5 nm), implicated, respectively in Alzheimer's disease and diabetes. The Scatchard analysis of surface plasmon resonance data obtained for a series of amphiphilic, PiB derivative GdL complexes indicate that their Aβ1-40 or amylin binding affinity varies with their concentration, thus micellar aggregation state. The GdL chelates also affect peptide aggregation kinetics, as probed by thioflavin-T fluorescence assays. A 2D NMR study allowed identifying that the hydrophilic region of Aβ1-40 is involved in the interaction between the monomer peptide and the Gd3+ complex. Finally, ex vivo biodistribution experiments were conducted in healthy mice by using 111 In labeled analogues. Their pancreatic uptake, ∼3 %ID g-1 , is promising to envisage amylin imaging in diabetic animals.

Front Cover: Concentration‐Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin (Chem. Eur. J. 6/2021)

Front Cover: Concentration‐Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin (Chem. Eur. J. 6/2021)

Concentration-Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin*.

Invited for the cover of this issue are Jean-François Morfin and Éva Tóth at the CNRS in Orléans, and their collaborators from University of Debrecen, University of Coimbra and Université de Toulouse. The image depicts that when an amphiphilic compound is intravenously injected, monomer, pre-micellar and micellar forms can co-exist in the blood and have different affinities for amyloid peptides. Read the full text of the article at 10.1002/chem.202004000.

Metal Complexes of acetohydrazide Derivative: Characterization, and Antimicrobial Activity Study

A novel derivative of 2,3-disubstituted quinazolin4(3H)-ones has been produced as of p-methoxybenzoylchloride and anthranilic acid, this prepared compound was used to produce a stable complexes. The ligand and complexes were isolated from the reaction in the solid form and characterized by FT-IR, UV-Visible, TLC, 1H NMR data and some physical measurements. Magnetic susceptibility data coupled with electronic spectra suggested octahedral structure of the complexes. The ligand and complexes were also employed with various bacterial. The products exhibited that the metal complexes have larger antimicrobial activities than ligand.

Nano metal-complexes of theophylline derivative: synthesis, characterization, molecular structure studies, and antibacterial activity

The new divalent nano metal-complexes of Zn(II), Mn(II), and Fe(II) with new ligand derivate from theophylline were synthesis by ultrasonic sonication method. This method was applied to produce smaller, narrow distributed nanoparticles and without any aggregations. The nanocomplexes and new ligand (L) were diagnosed by different Physico-chemical studies as Analysis of elements (C.H.N), Measuring conductivity, FT-IR spectra, 1H NMR spectra, UV-Vis spectra, flame atomic absorption (FAA), and their microbial activities. The spectroscopic data of the nanocomplexes suggest their 2:1 (L: M) complex structures of Mn(II), Fe(II), and 1:1 (L: M) complex structure of Zn(II). Also, the spectroscopic studies suggested the octahedral structure for Mn(II) and Fe(II) ions and tetrahedral structure for Zn(II) ion. All spectroscopic data propose that new ligand act as a bidentate ligand with its metal ions. The size and morphology of nanocomplexes measured by TEM were in range (14-18) nm. The bacterial activity was checked with the synthesized ligand and nanocomplexes. Activities show that the nano complexes are more promising than their new ligand for microbial activities.

Synthesis, spectral and thermo-kinetics explorations of Schiff-base derived metal complexes

AbstractSchiff-base ligand, 2,6-bis(benzimino)-4-phenyl-1,3,5-triazine (L), and its transition metal complexes of Co(ii), Ni(ii), and Cu(ii) were synthesized by refluxing the reaction mixture and its analytical, spectral, and thermogravimetric characteristics were explored by various techniques: AAS, FT-IR, UV-vis, TG-DTG, CHNS/O, and VSM. It was observed that all the metal containing complexes are non-electrolytic, mononuclear, and paramagnetic in nature, confirmed by the molar conductance and magnetic susceptibility measurements. Optical spectral data were used to investigate the geometrical and spectral parameters of [Co(L)(ac)2], [Ni(L)(ac)2], [Cu(L)(ac)2], [Cu(L)(acac)2], and [Cu(L)(fmc)2] complexes. Simultaneous thermal analyses (TG-DTG) in nitrogen atmosphere reveal that the ligand decomposes in one step, [Co(L)(ac)2], [Ni(L)(ac)2], and [Cu(L) (ac)2] complexes are decomposed in three steps, whereas [Cu(L)(acac)2] and [Cu(L) (fmc)2] are decomposed in five and two steps, respectively. In addition, activation energy (Ea) and pre-exponential factor (ln A) were evaluated by TG-DTG decomposition steps of compounds using the Coats–Redfern formula. Enthalpy (∆H), entropy (∆S), and Gibbs free energy (∆G) of the as-prepared metal complexes were also speculated by various thermodynamic equations.