Metal Carboxylate Research Articles

Development of Effective Bidentate Diphosphine Ligands of Ruthenium Catalysts toward Practical Hydrogenation of Carboxylic Acids

Abstract Hydrogenation of carboxylic acids (CAs) to alcohols represents one of the most ideal reduction methods for utilizing abundant CAs as alternative carbon and energy sources. However, systematic studies on the effects of metal-to-ligand relationships on the catalytic activity of metal complex catalysts are scarce. We previously demonstrated a rational methodology for CA hydrogenation, in which CA-derived cationic metal carboxylate [(PP)M(OCOR)]+ (M = Ru and Re; P = one P coordination) served as the catalyst prototype for CA self-induced CA hydrogenation. Herein, we report systematic trial-and-error studies on how we could achieve higher catalytic activity by modifying the structure of bidentate diphosphine (PP) ligands of molecular Ru catalysts. Carbon chains connecting two P atoms as well as Ar groups substituted on the P atoms of PP ligands were intensively varied, and the induction of active Ru catalysts from precatalyst Ru(acac)3 was surveyed extensively. As a result, the activity and durability of the (PP)Ru catalyst substantially increased compared to those of other molecular Ru catalyst systems, including our original Ru catalysts. The results validate our approach for improving the catalyst performance, which would benefit further advancement of CA self-induced CA hydrogenation.

In Vitro Evaluation of the Stabilization Time of Chemical Bonds During Setting Reaction and Microhardness of Preheated Glass-Ionomer Cements.

To evaluate the effect of preheating glass-ionomer cement (GIC) restorative materials on stabilization time (ST) of their metal carboxylate bonds and on microhardness. Two conventional high-viscosity GICs, Ketac Universal (3M ESPE) and Equia Forte (GC), were evaluated. The thermographic camera was used to measure the temperature inside the glass-ionomer cement capsules before and after heating. The preheating of capsules was performed at 54°C for 30 seconds in a commercial device. Characterization of ST in the GICs was determined by Fourier Transform Infrared (FTIR) spectroscopy. For this, 10 samples of each material were prepared, five in the non-preheated group (control) and five with preheating. FTIR spectra were obtained 10 minutes after mixing (control group) or after heating and then every 10 minutes for 120 minutes. For the microhardness test, 20 cylindrical specimens (3 mm height x 6 mm diameter) were prepared for each material (10 preheated, 10 control). The microhardness was determined at three time intervals: 10 minutes after mixing, after the ST as detected through the FTIR part of the study, and after one week. Knoop microhardness was assessed using a diamond indenter with a 25 g load and 15 seconds dwell time. Ketac Universal showed an increase in temperatures of 15.7°C for powder and 3.6°C for liquid, while Equia Forte showed 16.4°C for powder and 8.5°C for liquid. FTIR spectra indicated that preheating reduced the ST for Equia Forte but increased it for Ketac Universal. Preheating increased the initial microhardness (T1) of Equia Forte. With maturation over one week, it was observed that preheating significantly improved the microhardness of both materials compared with the control specimens. Preheating influenced the ST and the microhardness of Ketac Universal and Equia Forte. The ST and microhardness of Ketac Universal increased after seven days, whereas Equia Forte showed a reduced ST and increased microhardness from the outset.

Regulation of superoxide dismutase activity in soybean plants by inoculating seeds with rhizobia containing nanoparticles of metal carboxylates under conditions of different water supply

Soybean is one of the most profitable advanced crops in agricultural production in Ukraine and the world as a whole. Therefore, studies of means of regulation and increase in the adaptive capacity of soybeans in symbiosis with nodule bacteria under the action of unfavourable environmental factors are relevant and should be aimed at the use of complex bacterial compositions involving modern nanotechnological approaches. Nanocarboxylates of ferrum, molybdenum and germanium metals were used as components of rhizobia inoculation suspension for soybean seed treatment to study the effectiveness of their complex effect on the regulation of the activity of the key antioxidant enzyme superoxide dismutase in plants under drought. Various symbiotic systems were used, which included soybean plants and inoculation suspensions based on the active, virulent Tn5-mutant Bradyrhizobium japonicum B1-20 by adding nanoparticles of ferrum, germanium and molybdenum carboxylates to the culture medium in a ratio of 1: 1000. Citric acid was the chelator. A model drought lasting 14 days was created during the period of active fixation of atmospheric molecular nitrogen by root nodules of soybeans in the budding and flowering stages, by means of controlled watering of plants to 30% of the total moisture content. In the stage of bean formation, watering of plants was resumed to the optimal level – 60% of the total moisture content. The control was soybean plants, the seeds of which were inoculated with a suspension of rhizobia without the addition of chelated metals. The following research methods were used in the work – microbiological, physiological and biochemical. According to the results, it was found that when nanoparticles of carboxylates of ferrum, molybdenum and germanium were added to the inoculation suspension of rhizobia, there was an increase in superoxide dismutase activity in root nodules and a decrease in soybean leaves under optimal water supply conditions of plants. This indicates the initial changes in the activity of the antioxidant enzyme in these symbiotic systems, induced by the influence of chelated metals in combination with the rhizobia of the active Tn5-mutant B. japonicum B1-20. Prolonged drought induced an increase in the overall level of superoxide dismutase activity in soybean nodules and leaves, compared to plants grown under optimal watering conditions. The symbiotic system formed by soybeans and B. japonicum with molybdenum carboxylate nanoparticles was the most sensitive to long-term drought exposure, compared to two other soybean-rhizobial symbioses using ferrum and germanium nanocarboxylates. This was manifested in the unstable reaction of the enzyme to the action of drought – suppression or intensification of the level of its activity in the root nodules and leaves of soybeans inoculated with rhizobia containing molybdenum carboxylate nanoparticles. In symbiotic systems with the participation of germanium and ferrum nanocarboxylates, slight changes were revealed in superoxide dismutase activity in root nodules and leaves of plants during drought and restoration of enzyme activity to the level of plants with optimal watering after water stress. It is concluded that the addition to the culture medium of rhizobia Tn5-mutant B1-20 of nanocarboxylates of germanium or ferrum is an effective means of regulating the activity of the antioxidant enzyme superoxide dismutase in soybean root nodules and leaves, which can contribute to an increase in the protective properties and adaptation of plants to the action of dehydration.

Monitoring UV-accelerated alteration processes of paintings by means of hyperspectral micro-FTIR imaging and chemometrics

We explored the potential of infrared hyperspectral microimages to investigate the alteration of organic binders in pictorial layers after artificial UV light ageing. A set of paint mockups was prepared considering three different binders, namely, rabbit glue (a collagen-based proteinaceous binder), linseed oil (representative of drying oils) and egg tempera (a mixture of egg yolk and linseed oil). Four pigments (vermilion, orpiment, azurite and lead white) were considered in order to investigate the influence of pigment-binder interaction, following color changes by means of fiber optic reflectance spectroscopy (FORS). FTIR micro-images provided a representative picture of the complex and heterogeneous structure of paintings since each pixel contained the whole spectrum of the sample area from it was recorded. Principal component analysis (PCA) was used to analyze the FTIR images data in order to extract useful information about spectral changes taking place during UV induced ageing.Significant trends were observed, mainly depending on the binders and their degradation as a consequence of UV exposition in this pilot study on model samples. Several processes, such as the oxidation of proteins with the formation of carbonyl moieties and changes in amide band positions have been detected in the case of rabbit skin glue. The evaporation of linseed oil, probably due to the breakdown of the triacylglycerols, has been noticed for the binder alone but not when it was mixed with the pigments. In these cases, other spectral features depending on the pigment have been observed in the loading plots upon oxidation, namely the broadening of the carbonyl band, the appearance of carboxylic and dicarboxylic acids and the formation of metal carboxylates. For egg tempera, the main changes detected were related to the oxidation of lipidic components present in egg yolk fraction. Furthermore, in this case, the trend observed in the score graphs suggested that the presence of lead white accelerates its oxidation. It is interesting to note the major stability of the colored pigments when using this binder.

3-Methyl-2-(phenylsulfonamido)butanoic Acid and Its Metal Complexes: Synthesis, Crystal Structure, Antimicrobial, and Enzyme Inhibition Activity

In this study sulfonamide ligand, 3-methyl-2-(phenylsulfonamido)butanoic acid, has been synthesized and introduced in complexation with metals Cu, Zn, Fe, Ni, and Cd. Diorganotin and triorganotin complexes have been also prepared. The synthesized ligand and its metal complexes have been characterized by FTIR and mass spectrometry, and single crystal X-ray diffraction. The molecules are connected with each other via N–H···O–Hbond forming 2D polymeric network in the crystallographic plane (001) with base vectors [100] and [010]. Intermolecular interactions have been also studied by Hirshfeld surface analysis. Biological activities of the compounds including radical scavenging, total antioxidant potential, enzyme inhibition, antifungal, and antibacterial have been tested. Triorganotin carboxylates demonstrate high activity against four bacterial strains and one fungi (Aspergillus niger). Transition metal carboxylates (Ni and Fe) have demonstrated moderate antioxidant activity. Among Sn carboxylates dialkylstannyl complex has exhibited some response. In case of enzymes inhibition, Ni carboxylates have demonstrated the highest activity against butyrylcholine esterase but moderate activity against acetylcholine esterase.

Structure-property and bioimaging application of the difunctional polyarylene ether nitrile with AIEE feature and carboxyl group

A series of AIEE and carboxyl difunctional polyarylene ether nitrile (PEN) were synthesized via stepwise polymerization. Their structure-property and bioimaging application were studied. The synthesized PEN exhibited excellent thermal resistance with thermal decomposition temperature beyond 380 °C and glass transition temperature over 192 °C. Incorporation of AIEgen imparted PEN with a higher quantum yield (36%), and emission peak redshift from weak blue to bright cyan region under solid state. The soluble polymer also can be processed into flexible films by casting method with good mechanical property and strong fluorescent emitting. Under the synergistic action of difunctional segments, PEN was endowed with the assembled fluorescent polymeric nanoparticles (FPNs) though the coordination effect between metal ions and carboxyl group with much higher emission efficiently. Finally, based on the well biocompatible and hydrophilia of difunctional PEN, the obtained FPNs revealed the cellular bioimaging application. The current work lays the foundation for PEN perform as a high-performance engineering polymer with fluorescent perform in the development of optical applications.

Efficient One-Step Conversion of a Low-Grade Vegetable Oil to Biodiesel over a Zinc Carboxylate Metal-Organic Framework.

In this study, a metal–organic framework, namely, Zn3(BTC)2 (BTC = 1,3,5-benzenetricaboxylic acid), was solvothermally synthesized and employed as a catalyst for biodiesel production from degummed vegetable oil via a one-step transesterification and esterification reaction. The resulting Zn3(BTC)2 particles exhibit a well-defined triclinic structure with an average size of about 1.2 μm, high specific surface area of 1176 m2/g, and thermal stability up to 300 °C. The response surface methodology–Box–Behnken design (RSM–BBD) was employed to identify the optimal reaction conditions and to model the biodiesel yield in relation to three important parameters, namely, the methanol/oil molar ratio (4:1–8:1), temperature (45–65 °C), and time (1.5–4.5 h). Under the optimized reaction conditions (i.e., 6:1 methanol/oil molar ratio, 65 °C, 4.5 h), the maximum biodiesel yield reached 89.89% in a 1 wt % catalyst, which agreed very well with the quadratic polynomial model’s prediction (89.96%). The intrinsic catalytic activity of Zn3(BTC)2, expressed as the turnover frequency, was found to be superior to that of other MOF catalysts applied in the transesterification and esterification reactions. The reusability study showed that the as-synthesized Zn3(BTC)2 catalyst exhibited good stability upon three consecutive reuses without a noticeable decrease in the methyl ester yield (∼4%) and any appreciable metal leaching (<5%). Furthermore, a preliminary technoeconomic analysis showed that the total direct operating cost for the kilogram-scale production of Zn3(BTC)2 is estimated to be US$50, which may sound economically attractive.

Alkali Metal Carboxylates: Simple and Versatile Initiators for Ring-Opening Alternating Copolymerization of Cyclic Anhydrides/Epoxides

In this contribution, we thoroughly investigated the ring-opening alternating copolymerization (ROAC) of cyclic anhydride and epoxide by using commercially available alkali metal carboxylates (AMCs...

Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid

Abstract Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic head (citric acid moiety) and a hydrophobic tail (non-polar alkyl chain). The putative composition of the carboxylates was assigned on grounds of elemental analysis, infrared (IR) and high-resolution mass spectra (HR-MS), as well as in analogy with known complexes containing the citrate moiety. The metal carboxylates showed interesting activity in several microbial strains, especially against S. aureus (vanadium complex; MIC = 0.05 mg/ml). They were also tested for their cytotoxic activity in hepatocytes, the highest activity having been found in the copper(II) and manganese(II) complexes. Further research based on these preliminary results is needed in order to evaluate the influence of parameters like stability of the metal complexes in solution on the bioactivity of the complexes.

Synthesis and Spectrophotometric Properties of Sodium Metal Carboxylates

While metal carboxylates are by no means rare or inaccessible, complete characterization with notable exception of acetates is largely neglected hence a deficiency within the carboxylate literature giving rise to discrepancies within the characterization data available thus, spectroscopic properties of synthesized sodium metal carboxylates of acetic acid and myristic acid were investigated using Atomic Absorption Spectroscopy (AAS), flame photometry, FTIR spectrophotometer and UV- Visible spectrophotometry. AAS and flame photometric results showed elemental abundance of the sodium metals in the carboxylate complexes. FTIR spectra data revealed ʋCOO- absorptions at 1636 cm-1 and 1558 cm-1 for sodium acetate and sodium myristate respectively. The free acid ligands showed absorptions at 1703 cm-1 for acetic acid which shifted to 1636 cm-1 for sodium acetate. FTIR absorption of myristic acid revealed a strong absorption band at 1696 cm-1 which shifted to 1558 cm-1 in sodium myristate. The geometry of the complexes were determined by the magnitude of separation, Δʋ, which is equal to ʋaym - ʋsym,. The values of Δʋ for the synthesized sodium acetate complex was found to be 231 cm-1 and 138 cm-1 for sodium myristate indicating monodentate and bridging bidentate bonding respectively. Force constants of the carboxylates which correspond to their bond energies were found to be 1495.94 K NM-1 and 1358 K NM-1 for sodium acetate and sodium myristate, respectively. The UV- Visible analysis shows ʎ max values of 201 nm and 195 nm for sodium acetate and sodium myristate respectively, which corresponds to the absorption of the COO chromophore which is due to n-π* transition.

Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature.

Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean product without column chromatography. Our reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). We believe that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales.

Studies of the early stages of the dynamic setting process of chemically activated restorative glass-ionomer cements

Objective To evaluate the early stages of the setting process of chemically activated restorative glass-ionomer cements (GICs). Material and methods Five GICs were evaluated (n = 5): Equia Forte (GC), Equia Forte HT (GC), Ketac Universal (3M ESPE), Maxxion R (FGM) and Riva Self Cure (SDI) by Thermography, Fourier Transform Infrared Attenuated Total Reflectance Spectroscopy (FTIR-ATR) and Gillmore needle indentation mechanical testing. The FTIR-ATR spectra showed the formation of metal carboxylates within the cements and enabled the stabilization time (ST) to be determined and the thermographic camera measured the temperature field images in the sample. Data were statistically analyzed by ANOVA and Tukey–Kramer (α = 5%). Results The Gillmore needle test showed that the order of hardening was opposite to the order of ST values determined by FTIR. The results with the thermographic camera showed two stages of temperature variation, which coincided with the evolution of specific infrared bands. The exception was Maxxion R, which showed only a single step change in temperature. Conclusion The early stages of the GIC setting reaction show temperature changes, both endothermic and exothermic, at specific times, confirming the occurrence of individual chemical reactions. The early setting involves reactions other than carboxylate formation. Significance: This study gives further detail of the early stages of the setting of GICs, and past research regarding the setting reaction of GIC.

Synthesis and characterization of bis(amine)palladium(II) carboxylate complexes as precursors of palladium nanoparticles.

The synthesis and characterization of the adducts of n-alkyl amine and palladium n-alkyl carboxylate, [Pd(R2NH2)2(R1COO)2] (R1 = 1, 7, and 11; R2 = 8, 12, and 16), as precursors for the synthesis of palladium nanoparticles (PdNPs) was carried out via differential scanning calorimetry, FT-IR, Raman and UV-Vis spectroscopy, NMR spectroscopy (1H, 13C pulsed field gradient spin-echo (PGSE), and 13C CP-MAS), and powder X-ray diffraction. Pd n-alkyl carboxylates were obtained by a ligand exchange reaction from palladium acetate and the appropriate aliphatic carboxylic acid. It is proposed that carboxyl moieties in the presence of amine ligands are bound to palladium ions via monodentate bonding as opposed to bridging bidentate coordination of pure palladium carboxylate which exists in the form of polymer aggregates. All the studied palladium carboxylate/amine complexes form bilayer lamellar structures and exhibit first-order melting transitions. The evidence presented in this study shows that the phase behavior of bivalent metal carboxylates is mainly controlled by the type of coordination of carboxylate head groups. For n-alkyl carboxylates, linear chain type aggregates replace the trimeric units of Pd acetate. In solution, in the presence of amine, palladium salt aggregates disintegrate and the Pd complex is isolated and stabilized by amine molecules. Using bis(amine) palladium carboxylate adducts as precursors, palladium nanoparticles were fabricated. During high temperature thermolysis, the bis(amine) Pd carboxylate complex decomposes to form small sized Pd nanoparticles. Combining NMR techniques with FTIR spectroscopy, it was possible to follow an original stabilization mechanism. PdNPs are stabilized by weakly interacting long chain aliphatic amide and carboxylic acid derived from the palladium precursor.

Novel 3D-networked melamine–naphthalene–polyamic acid nanofillers doped in vinyl ester resin for higher flame retardancy

In this study, melamine–naphthalene covalent polyamic acid and its metal carboxylate salts were synthesized as building blocks of nanofillers (Nt–Mn–PA–COOM, M = Li, Na, and K).

Metal-dependent photochromic performance in two isostructural supramolecular chains.

The combination of a conjugated coplanar dipyridine moiety 1,10-phenanthroline (1,10-phen) with a metal carboxylate system produces two isostructural supramolecular chains [M(HBTA)(1,10-phen)2] (M = Zn for 1, M = Cd for 2) (H3BTA = benzene-1,2,3-tricarboxylic acid). Both 1 and 2 feature monomeric units as molecular building blocks (MBBs), which further connect with each other to form a supramolecular chain via forming hydrogen bonds with adjacent units. The coordinate linkage of 1,10-phen as π-electron acceptors (π-EAs) and tricarboxylate as electron donors (EDs) results in the electron transfer (ET)-induced photochromic functionality of 1 and 2 in response to Xe-lamp irradiation under ambient conditions. Distinct from the plenty of previous photochromic compounds derived from photosensitive moieties such as pyridinium-derivatives and photodeformable molecules, the photochromism in 1 and 2 is driven by the photoinduced ET between tricarboxylate and non-photochromic 1,10-phen units. Because of the coplanar characteristics of 1,10-phen, the photoactivated samples feature good stability under ambient conditions. More importantly, the resulting photochromism of isostructural 1 and 2 could be modulated by the category of metal ions, which is totally different from the previous works with focus on the design of organic ligands. Considering the great varieties of carboxylate ligands, this work offers a general method for the construction of photochromic complexes via integrating coplanar 1,10-phen units with metal-carboxylate systems under the guidance of the ET mechanism and MBB assembly strategy and modulating the photochromism of the resultant isostructural products via tuning the category of metal ions.

Applications of Raman spectroscopy in art and archaeology

Applications of Raman spectroscopy in art and archaeology

Systematic Study of the Properties of CdS Clusters with Carboxylate Ligands Using a Deep Neural Network Potential Developed with Data from Density Functional Theory Calculations.

Although structures of the inorganic core of CdS atomically precise quantum dots were reported, characterizing the nature of the metal-carboxylate coordination in these materials remains a challenge due to the large number of possible isomers. The computational cost imposed by first-principles methods is prohibitive for such a configurational search, and empirical potentials are not available. In this work, we applied deep neural network algorithms to train a potential for CdS clusters with carboxylate ligands using a database of energies and gradients obtained from density functional theory calculations. The derived potential provided energies and gradients based on a set of reference structures. Our trained potential was then used to accelerate genetic algorithm and molecular dynamics simulations searches of low-energy structures, which in turn, were used to compute the X-ray diffraction and electronic absorption spectra. Our results for CdS clusters with carboxylate ligands, analyzed and compared with experimental findings, demonstrated that the structure of a cluster whose properties agree better with experiment may deviate from the one previously assumed.

Structural, spectroscopic insights, and antimicrobial properties of mononuclear and dinuclear metal(II) carboxylate derivatives with metronidazole

A dinuclear paddle-wheel complex [Cu2(PTA)4(mnz)2] (1) and mononuclear [M(BBA)2(mnz)2(H2O)2] complexes, where PTA = p-methylbenzoate, BBA = 2-bromobenzoate, mnz = metronidazole and M = Cu(II) (2), Co(II) (3), Ni(II) (4), Zn(II) (5), Cd(II) (6) were prepared by adding metronidazole to the mixture of divalent metal nitrate salts and arylcarboxylate acid in alkaline aqueous solution under ambient conditions. The complexes were characterized by elemental analysis, spectroscopy (FTIR, UV–visible and NIR-Vis-UV), single crystal X-ray diffraction (SCXRD), Hirshfeld surface analysis and High-Field EPR. The asymmetry of the d − d bands observed in the electronic diffuse − reflectance spectra of cobalt(II) and nickel(II) complexes is due to the symmetry lowering from Oh to elongated D4h in trans − [MN2O2O2′] chromophores. Large zero-field splitting was observed in the HF EPR spectra of the Ni(II) and Co(II) complexes which was modeled by using the CASSCF method. The antimicrobial activity was studied using the agar well diffusion method. The antimicrobial tests of these new compounds were carried out on Candida albicans and five bacterial strains (three Gram-negative and two Gram-positive), and were compared to their respective parent ligands. A broad antimicrobial spectrum was observed in some of the complexes.

The influence of the nature of carboxylate precursors on the composition and tribological performance of copper-containing nanomaterials

In this study, a comparative study of nanomaterials formed during thermolysis at 300 °C of two representative metal carboxylates (copper capronate and valerate) was carried out. The obtained nanoparticles (NPs) were studied using X-ray diffraction, atomic force microscopy and sedimentation analysis. Copper(I) oxide and copper are the main decomposition products of copper capronate. The crystallite size of copper(I) oxide is from 20 to 30 nm, and that of Cu crystallites is from 11.2 to 11.3 nm and is practically independent of the thermolysis time. The decomposition of copper valerate produces copper(I) oxide with a size of 20 to 50 nm, and the dispersion of particles depends on the thermolysis time of the samples. Analysis of copper-containing nanomaterials as additives to lubricants (Ciatim-221 and liquid paraffin) was carried out in terms of their tribological behavior using a pin-on-disc and four-ball machine tribometers. The introduction of copper(I) oxide NPs reduces the friction coefficient of Ciatim-221 lubricant and liquid paraffin by 26% and 39%, respectively. The microstructure of the friction surface depends on the presence of copper oxide NPs in the lubricant and on the nature of the lubricant base.

Synthesis, single-crystal X-ray diffraction, and in vitro biological evaluation of sodium, cobalt, and tin complexes of o-nitro-/o-methoxyphenylacetic acid: experimental and theoretical investigation

Four new metal carboxylates with o-nitro- and o-methoxyphenylacetic acid were synthesized and well characterized using single-crystal XRD. The synthesized complexes were evaluated for their biological potentials (antibacterial, antifungal, antioxidant, and enzyme inhibition) according to reported methods. Four bacterial and two fungal strains were targeted in this study and it was concluded that the synthesized compounds showed activities comparable to standard drugs. Co complex of nitro and tin complex of methoxy substituent are more active against bacterial as well as fungal strains. Enzyme inhibition activity of the synthesized compound was evaluated against acetylcholine esterase, butyrylcholine esterase, and trypsin. The maximum activity was depicted by Co complex of nitro, while all other tested compounds had moderate to good activity. DFT calculations were performed to gain further insight into the spectral properties. Docking model was also used to check the interaction of most active compound on the active site of the enzyme. All theoretical parameters supported the practical calculation and our findings that such compounds may be the best molecules in the near future against infectious as well as Alzheimer disease.