BACKGROUND AND AIM: The European Human Exposome Network (EHEN) unites 9 research projects studying the impact of environmental exposure on health, such as air quality, noise, chemicals, and urbanization. We report for the Metadata WG with 1-2 delegates from each project to promote findability, accessibility, interoperability and reusability (FAIRness) of all EHEN data and to jointly develop a sustainable exposome data infrastructure. METHODS: We compared the data management plans from the network and selected open areas in need of harmonisation. We are establishing short-term sub working groups to develop standards and tools therefore and analyse requirements for a network data catalogue. And we reached out beyond EHEN to relevant semantic and non-semantic standard and tool development initiatives for collaboration (e.g. BBMRI, IHECC, ELIXIR, GA4GH, Maelstrom, EUCAN-connect, LifeCycle, EOSC-life, CINECA, FAIR genomes). RESULTS:We established an inventory of data modalities in the network, for example, chemical exposures, physical exposures, proteomics (25 main categories, 66 subcategories). We have chose three priorities for the sub working groups: standards for external exposome, omics and catalogue metadata. There is a draft catalogue for cross consortia dataset identification. It consist of 232 candidate metadata items organised in 6 areas: institutions (that provide access to data), data resources (databanks, datasets, cohorts, registries), networks (such as each project in EHEN), common data elements/standards (e.g. agreed upon harmonized data variables in a network), studies (uses of the data) and data harmonisations (sourceVariables, harmonizedVariables, and mappings between them). CONCLUSIONS:With first templates in place for both metadata and data we want to reach out to the world to join on our mission: develop FAIR data infrastructure that enables frictionless identification, selection and harmonized access of/to datasets for exposome studies in EHEN and beyond. KEYWORDS: FAIR, metadata, exposome, catalogue, semantics
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