Aldosterone Metabolic Clearance Research Articles

Aldosterone and sodium conservation: the effect of acute dietary sodium deprivation on the plasma concentration, the metabolic clearance and the secretion and excretion rates of aldosterone in normal subjects.

ABSTRACT The effect of dietary sodium deprivation on the metabolic clearance, metabolic rate constants, volumes of distribution, and disappearance rate of administered radioactive aldosterone as well as on the secretion and excretion rates and plasma concentration of aldosterone was studied in healthy subjects. Aldosterone secretion and excretion rates and the calculated plasma aldosterone concentration increased during the period of dietary sodium restriction. Using a 2-compartmental model system, results derived from analyses of the disappearance curves of tritiated aldosterone in plasma both before and during dietary sodium restriction did not reveal a change in the distribution volumes, the metabolic rate constants, or the metabolic clearance of aldosterone. Under the conditions of these studies the increase in plasma aldosterone concentration during dietary sodium deprivation was determined by the elevated rate of aldosterone secretion rather than by changes in the metabolic clearance of aldosterone....

PSYCHIATRIC DISTURBANCE LEADING TO POTASSIUM DEPLETION, SODIUM DEPLETION, RAISED PLASMA-RENIN CONCENTRATION, AND SECONDARY HYPERALDOSTERONISM

Nine psychiatrically disturbed women were studied, variously suffering from the effects of anorexia nervosa, vomiting, and abuse of diuretics and purgatives. Each had more than one source of electrolyte depletion, and each deliberately concealed at least one of these. All were potassium-depleted, and in all but one sodium depletion was also evident. During exacerbations plasma-renin concentration was raised, secretion-rate and plasma concentration of aldosterone were increased, and the metabolic clearance of aldosterone was diminished. It is suggested that in combined sodium and potassium deficiency, conservation of sodium may be relatively more effective than that of potassium, and that multiple routes of electrolyte loss prevent effective homœostasis.