Introduction The claustrum anatomy is quite remarkable for its reciprocal connections with almost all regions of the cortex. Although a multimodal integrative and/or synchronising role has been previously suggested, its function remains enigmatic so far. The present study had two main aims: First, we employed the database driven approach to investigate the task-dependent functional connectivity using meta-analytic connectivity modelling (MACM). Second, we performed a complementary resting-state (task-independent) functional connectivity (RSFC) analysis of an sample of healthy subjects. Methods The regions of interest (ROIs) for both MACM and RSFC were manually drawn in the left and right claustrum on a standard space template. For MACM, the ROIs were input as seed regions into the BrainMap database (http://BrainMap.Org) (Laird et al., 2009). The significant areas of coactivation were obtained using modified activation likelihood estimation (ALE) algorithm (Eickhoff et al., 2012). For RSFC, a dataset of 50 healthy volunteers (25 males, average age 31.36) was downloaded from the NKI/Rockland sample (Nooner et al., 2012). We employed seed-based general linear model analysis, as implemented in FSL v5.0 (http://www.fmrib.ox.ac.uk/fsl) (Jenkinson et al., 2012). The modelled time-series were extracted from the preprocessed data in each ROI. To account for head motion and physiological noise, the model further included several vectors of nuisance signal. Both MACM and RSFC maps were registered to a common MNI152 standard space. Additionally, connectivity of the putamen and insula was subtracted or regressed out in the model to avoid false positives due to partial volume effect and spatial filtering. Next, contrast analysis of resulting maps for the left and right claustrum was performed to detect possible asymmetries. The resulting maps were thresholded at corrected p Results Both MACM and RSFC have shown similar and mainly symmetrical pattern of connectivity including the contralateral claustrum, ventrolateral thalami, lentiform nuclei, cerebellum, pons, bilateral precentral cortices (BA6), supplementary motor area, insular and frontoparietal opercular cortices. At lower Z threshold, the RSFC maps resembled a combination of several resting-state networks – including task-positive, sensorimotor and salience networks, while excluding mainly rostral frontal and ventral temporal cortices, and so-called default mode network located to posterior cingulate, precuneous cortex, and lateral occipital cortices. Moreover, some striking asymmetries were observed: left claustrum connecting more to the left inferior frontal gyrus (BA44), superior frontal gyrus and left thalamus. On the other hand, the right claustrum showed stronger connections to the right superior and inferior parietal lobule. Conclusions Our findings provide novel evidence for the connectivity of the claustrum, suggesting a more specific role in sensorimotor and task-positive systems.