Mesoporous Silicon Dioxide Research Articles

Physical-Matched Nanoplatelets Boost Heterogeneous Thrombi Targeting Through Self-Adaptive Deformation for Thrombolysis and Endothelial Repairing.

The heterogeneity of thrombi in terms of composition, structure, and blood rheology parameters presents a challenge for effective thrombus-targeting drug delivery. To address this, a self-adaptive nano-delivery system, termed D-PLT, is developed. It consists of platelet membrane-cloaked deformable mesoporous organic silicon dioxide nanocomposite, enabling it to respond to the challenge of the heterogeneity of thrombi in arteries and veins. The system exhibits progressive targeting, with the ability to target arterial and venous thrombosis and damaged blood vessels. D-PLT physically matches the pore structure of the thrombus by undergoing varied deformation, leading to advanced targeting and enrichment of arterial and venous thrombus. When co-loaded with the thrombolytic drug urokinase (UK) and the endothelium-protecting agent atorvastatin calcium (AT), the system improves rapid vascular opening of arterial and venous thrombosis in 90 min and provides up to 7 days of durable thrombolysis and recovery from endothelial dysfunction in vivo. This self-adaptive delivery system offers a promising strategy to overcome thrombus heterogeneity.

Sequestration of Ni2+ and Zn2+ utilising agricultural biowaste-based amorphous M−SiO2 and modified green M−SiO2/Fe3O4 nano-adsorbents: Modelling and electroplating wastewater performance

This work reports the synthesis of novel amorphous mesoporous silicon dioxide (M−SiO2) nanoparticles and modified hybrid green mesoporous silicon dioxide embedded magnetite (M−SiO2/Fe3O4) nanocomposite by one-pot co-precipitation green approach. The nano-adsorbents’ ability to sequester Ni2+ and Zn2+ ions was investigated in batch experiments using synthetic solutions. The M−SiO2/Fe3O4, having specific surface area of 171.71 m2/g and mesoporous diameters of 6.281 nm, exhibits soft ferromagnetism with a saturation magnetisation of 35.45 emu/g. Specific surface areas and mesoporous diameters of 909 m2/g and 2.288 nm were recorded for M−SiO2. The Langmuir isotherm, pseudo second order kinetic, and Elovich kinetic were found to be best fitted to explain the highest capability of adsorption. The Langmuir monolayer coverage (qmax) of 108.70 and 96.15 mg/g for Ni2+ and Zn2+ by M−SiO2/Fe3O4, respectively, was notably higher than M−SiO2 (80.65 and 72.46 mg/g). The best-fitted kinetics imply that chemisorption predominates on M−SiO2 and M−SiO2/Fe3O4 heterogeneous adsorption surfaces. Thermodynamic parameters confirm endothermic adsorption of cationic metals, and sequestration improved marginally at elevated temperatures. The lab scale cost estimation, magnetic separability and superior metal ions sequestration efficacy of M−SiO2/Fe3O4 nanocomposite up to five ad-desorption cycles with > 90 % regenerability render it an economically feasible and recyclable nano-adsorbent. The feasibility of cationic metals sequestration from electroplating effluent confirms an effective and cost-efficient environmentally friendly nano-adsorbent (M−SiO2/Fe3O4) for treatment of wastewater contaminated with potentially toxic metals.

Investigation of In Vitro Toxicity of Newly Synthesized Mesoporous Silica Nanotubes with Different Pore Sizes in Human Liver Cancer Cells (HepG2)

Nanotechnology has gained importance in recent years with the use of nanomaterials smaller than human cells in many areas such as food, cosmetics, defense industry and pharmaceutical industry. It has begun to be widely used in the field of health in the diagnosis and treatment of many diseases, especially cancer. However, due to their size and content, these materials can be toxic and pose a risk to human health. In this study, the cytotoxic effects of mesoporous silicon dioxide (SiO2) nanoparticles with different pore sizes, synthesized using a new method and made from polyethylene glycol 6000 (PEG6000) and polyethylene glycol 35000 (PEG35000) were tested on HepG2 cells liver carcinoma cells. Additionally, the effects of mesoporous silica nanotubes on lipid peroxidation and reactive oxygen species (ROS) were also examined. It was found that the cytotoxicity of both types of mesoporous SiO2 nanoparticles increased with rising concentration. Cell viability decreased significantly as the nanoparticles dosage (100-10 μg/mL) increased. Both nanoparticles were not cytotoxic at concentrations up to 50 µg/mL, however, they became cytotoxic at higher concentrations (p

Investigation of the mechanical and physical properties of mesoporous silicon dioxide fillet epoxy composites

In this study, the effect of mesoporous silicon dioxide (M-SiO2) additives with different surface areas and pore diameters on the morphological and mechanical properties of epoxy composites was investigated. For this purpose, M-SiO2 particles with different pore diameters and surface areas were synthesized from polyethylene glycol (PEG) with three different molecular weights (PEG2000 (PEG2), PEG6000 (PEG6), and PEG35000 (PEG35) kDa) using the one-step sol-gel technique. The mixing of epoxy resin, hardener and M-SiO2 fillers, was carried out in a mould followed by using ultrasonic bath and mechanical stirrer.The mechanical properties of the composites, including hardness, tensile strength, elongation at break, and modulus of elasticity, were studied. FT-IR spectra and XRD patterns show that M-SiO2 is distributed homogeneously in the epoxy. The epoxy/PEG35M-SiO2 composites' tensile strength (8.7%) and modulus of elasticity (23.3%) increased with the addition of PEG35M-SiO2, however their elongation at break (5.1%) decreased.

Mesoporous silica coated spicules for photodynamic therapy of metastatic melanoma

We report on the fabrication of mesoporous silicon dioxide coated Haliclona sp. spicules (mSHS) to enhance the delivery of the insoluble photosensitizer protoporphyrin IX (PpIX) into deep skin layers and mediate photodynamic therapy for metastatic melanoma in mice. The mSHS are dispersed sharp edged and rod-like micro-particles with a length of approximate 143.6 ± 6.4 μm and a specific surface area of 14.9 ± 3.4 m2/g. The mSHS can be topically applied to the skin, adapting to any desired skin area and lesion site. The insoluble PpIX were incorporated into the mesoporous silica coating layers of mSHS (mSHS@PpIX) with the maximum PpIX loading capacity of 120.3 ± 3.8 μg/mg. The mSHS@PpIX significantly enhanced the deposition of PpIX in the viable epidermis (5.1 ± 0.4 μg/cm2) and in the dermis (0.5 ± 0.2 μg/cm2), which was 154 ± 11-fold and 22 ± tenfold higher than those achieved by SHS, respectively. Topical delivery of PpIX using mSHS (mSHS@PpIX) completely eradicated the primary melanoma in mice in 10 days without recurrence or metastasis over 60 days. These results demonstrate that mSHS can be a promising topical drug delivery platform for the treatment of diverse cutaneous diseases, such as metastatic melanoma.Graphic

다공성의 콜로이드성 이산화규소를 이용한 닐로티닙 함유 고형의 자가미세유화 약물전달시스템의 개발

The objective of this study was to develop a novel nilotinib HCl-loaded solidified self-nanoemulsifying drug delivery system (SNEDDS) formulation with enhanced solubility and dissolution rate. Various oils and surfactants were screened, resulting in the selection of Peceol (oil) and Tween 80 (surfactant) and Transcutol P (co-surfactant). Pseudoternary phase diagram was constructed to detect the nanoemulsion zone. Among the SNEDDS formulations tested, the SNEDDS consisting of Peceol (oil), Tween 80 (surfactant), and Transcutol P (co-surfactant) at a weight ratio of 30/50/20 produced an emulsion droplet size of 182.1±1.0 nm. The spray drying technique, using mesoporous silicon dioxide as an inert carrier, was employed to solidify the selected nilotinib HCl-loaded SNEDDS. The resulting nilotinib HCl-loaded solid SNEDDS (S-SNEDDS) was characterized by scanning electron microscopy (SEM), powder X-ray diffractometry (PXRD), dynamic light scattering, saturation solubility and in vitro dissolution study. The S-SNEDDS produced an emulsion droplet size of 185.2±0.9 nm and there was no change in emulsion particle size upon the addition of drug. SEM and PXRD results suggested that nilotinib HCl existed in an amorphous form in nilotinib HCl-loaded S-SNEDDS. Solubility tests across various pH levels showed a significant improvement in nilotinib HCl solubility. Similarly, dissolution tests demonstrated enhanced dissolution rates in all tested solutions, consistent with the solubility results. These results indicate that the employed methodologies were effective in increasing both the solubility and dissolution rates of nilotinib HCl across different pH environments, suggesting a successful enhancement of its bioavailability.

Assessing the production of galactooligosaccharides in batch and continuous mode by using β‐galactosidase immobilised on mesoporous silicon dioxide nanoparticles

SummaryThe present study evaluated the production of galactooligosaccharides (GOSs) from lactose in both batch and continuous modes using nano‐immobilised β‐galactosidase. Mesoporous silicon dioxide nanoparticles were used to immobilise β‐galactosidase to enhance the stability and production of GOSs. The change in enzyme‐characteristics was assessed using Fourier‐transform infrared and scanning electron microscope analysis. The nano‐immobilisation increased the enzyme's substrate affinity, but decreased its hydrolytic activity. A significant increase (P < 0.05) in stability was observed across a wide range of temperature (30 °C–70 °C) and pH (5.0–8.0). Both forms of enzymes (free and nano‐immobilised enzymes) followed the zero‐order reaction in all temperatures, while the nano‐immobilised enzyme had the highest activation energy. The free and nano‐immobilised enzymes retained 64.65% and 77.82% of their initial activity after 90 days of storage, respectively. In a batch mode, the nano‐immobilised enzyme produced 2.35 times more GOSs than the free enzyme. The GOSs production remained consistent while the enzyme activity decreased by 12.7% after 5 cycles of operation. The continuous mode of production in a packed bed reactor achieved a GOSs yield of 16.92%. Overall, the nano‐immobilised enzyme showed better GOSs production under batch and continuous mode of operation.

Preparation of nano-immobilised β-galactosidase using mesoporous silicon dioxide nanoparticles and its efficiency in production of galactooligosaccharides

The β-galactosidase (produced from Aspergillus oryzae) was immobilised on epichlorohydrin functionalised mesoporous silicon dioxide nanoparticles to produce galactooligosaccharides (GOS) from lactose. The characteristic amide bonds and increased particle size confirmed the adsorption of enzyme on nanoparticles. Nano-immobilisation resulted in an increase in enzyme affinity towards the substrate and its hydrolytic property. Free and nano-immobilised enzymes retained 58 and 77% of the original enzyme activity up to 90 days of storage, respectively. The nano-immobilised enzyme exhibited greater stability over a broad range of temperature (30–70 °C) and pH (5.0–8.0). The GOS yield obtained from nano-immobilised enzyme was 2.23 times higher than the free enzyme. GOS production was decreased by 90% and enzyme activity was reduced to 10% in a run of 5 cycles. Overall, the developed nano-immobilisation technique has potential to enhance the stability of the enzyme and GOS production.

Design of cost-effective environment-responsive nanoacoustic devices based on mesoporous thin films

Gigahertz acoustic resonators have the potential to advance data processing and quantum communication. However, they are expensive and lack responsiveness to external stimuli, limiting their use in sensing applications. In contrast, low-cost nanoscale mesoporous materials, known for their high surface-to-volume ratio, have shown promise in various applications. We recently demonstrated that mesoporous silicon dioxide (SiO2) and titanium dioxide (TiO2) thin layers can support coherent acoustic modes in the 5 to 100 GHz range. In this study, we propose a new method for designing tunable acoustic resonators using mesoporous thin films on acoustic distributed Bragg reflectors. By simulating the infiltration of the pores with water, we show that the material’s properties could be altered and achieve tunability in the acoustic resonances. We present four device designs and use simulations to predict resonators with Q-factors up to 1500. We also observe that the resonant frequency and intensity show a linear response to water infiltrated in the mesopores, with a tunability of up to 60%. Our platform offers a unique opportunity to design cost-effective nanoacoustic sensing and reconfigurable optoacoustic nanodevices.

A double network hydrogel dressing enhanced by catechin-loaded mesoporous silica for accelerating wound repair in conjunction with red-light therapy

The process of healing wounds is an intricate mechanism that the human body undergoes. However, the production of hydrogel dressings is expensive and involves a complicated manufacturing procedure. Furthermore, most wound dressings lack bioactive components, limiting their ability to actively promote wound healing. To address this issue, we have developed an adhesive hydrogel dressing for wound repair that possesses antibacterial, anti-inflammatory and antioxidant capabilities. The dressing is composed of polyethylene glycol diacrylate (PEGDA), chitosan (CS), and catechin-loaded mesoporous silicon dioxide (CMSN). The hydrogel dressing adheres tightly to tissues through topological adhesion of CS macromolecules. At the same time, CMSN slowly releases the active substance, catechin, at the wound site. Moreover, the intermolecular interactions and hydrogen bonding between CMSN and PEGDA/CS hydrogels enhance the mechanical stability of the dressing. This allows for effective closure and repair of wounds, even in areas with frequent movement. Additionally, red-light therapy can be employed to further promote wound healing. It works by enhancing blood circulation, improving wound oxygenation, and stimulating collagen synthesis. When combined with the biocompatible and adhesive hydrogel dressing, it offers a promising approach for the rapid repair of wounds in motorial wounded areas.

Mesoporous SiO2 anode armour for lithium oxygen battery

We are reporting a new lithium (Li) anode protective strategy using mesoporous silicon dioxide (mSiO2) to extend the operation lifetime for Li oxygen batteries (LOBs). The fabrication method is simple and easy for mass production. The mSiO2 protective layer inhibits the growth of Li dendrites and prevents the intrinsic Li corrosion phenomenon that occurs in all Li-metal-based batteries during charge/discharge cycles, the porous structure of nanoparticles within the mSiO2 also actively created parallel pathways for Li+ transport thus enhancing the mass transfer. Propylene carbonate/Li with a 100 μL drop amount of mSiO2 protective layer (mPL100) showed excellent per-formance in the Li||Li battery charge/discharge cycle test, withstanding 2,276 h of continuous operation, almost 16 times longer than the battery without the protective layer, and the LOB charge/discharge cycle test with the mSiO2 protective layer reached 382 cycles, another significant increase of 6.2 times over the unprotected battery, the full discharge capacity also reached 56,902 mAh/g that is nearly 19 times higher than the unprotected cell. Because the mSiO2 made Li+ flux more homogeneous meanwhile promoting the uniform distribution of positive electrode products and accelerating their decomposition, thus the overpotential is reduced. This layer also blocked any H2O and peroxide molecules which attack the Li anode, therefore the retention of Li has been kept at a satisfactory level.

Inorganic nanoparticles-modified polyvinyl chloride separation membrane and enhanced anti-fouling performance

Porous nanomaterials are important additives in the preparation of high-performance separation membranes. To prepare two nanocomposites, mesoporous silicon dioxide (MCM-41) as a carrier and zinc acetate as a zinc source, Zinc oxide-loaded mesoporous silicon dioxide (ZPP-MCM) was prepared by using polydopamine (PDA) and Polyethylenimine (PEI) as water-soluble ligands, and zinc oxide-loaded mesoporous silicon dioxide (εZI-MCM) were prepared by using iminodiacetic acid (IDA) as water-soluble ligands and coated with ε-poly-l-lysine HCl. The two nanocomposites were blended into polyvinyl chloride (PVC) membranes as modifiers. The results show that the overall porosity of the composite membrane is increased. However, the surface roughness of the composite membrane is decreased with narrow pore size distribution, which was favourable for selective filtration. εZI-MCM nanoparticles can be evenly distributed on the film due to their excellent dispersion, which solves the problem of uneven distribution of nanoparticles on the film, and the surface of the prepared composite film is relatively flat. In addition, introducing the nanoparticles significantly improves the surface hydrophilicity and water flux of the composite membrane. In the experiments of pure water flux and bovine serum albumin (SBA) flux, the flat film with nanoparticles shows higher flux than pure PVC films. The addition of nano-composites further improves the anti-fouling performance and flux recovery ratio of the modified PVC membrane, and the recovery ratio of flux was more than 90%. This work exhibits that Porous nanomaterials have successfully modified the hydrophobic PVC membrane, affording good anti-fouling performance.

ПЕРСПЕКТИВА ПРИМЕНЕНИЯ ГИБРИДНОГО ПОРОШКОВОГО МАТЕРИАЛА AgI-SiO2 В СОСТАВЕ ПРОТИВОГРАДОВОГО РАКЕТНОГО ТОПЛИВА

The work proposes new hybrid powder materials as sediment-converting reagents used in geoengineering technologies (technologies for artificial precipitation management). Hybrid powder materials AgI-SiO2 are mesophase mesoporous silicon dioxide with silver iodide. They were obtained through the “Paste Formation” process, which involves constant mixing of an aqueous condensed suspension of silicon dioxide of various types with the sequential addition of silver nitrate and potassium iodide. The characteristic features of the synthesized AgI-SiO2 hybrids were studied using instrumental methods of analysis: structural, textural and rheological parameters. The influence of hybrid powder material AgI-SiO2 (HPs) on the efficiency of anti-hail rocket fuel is shown using the TERRA software system for modeling phase and chemical equilibrium at high temperatures. It is certain that using HPs AgI-SiO2 as part of anti-hail rocket fuel leads to an increase in the amount of condensed phase, including active forms of silver iodide. This active form of AgI is required for the implementation of ice formation processes in the cloud. An increase in the amount of the β-form of AgI in the composition of the initial HPs was shown compared to pure silver iodide using X-ray phase (XRF) analysis and differential scanning calorimetry. It was established that silver iodide in the hybrid has greater thermal stability, as evidenced by the characteristic peaks of crystalline forms. HPs AgI-SiO2 will improve the efficiency of anti-hail rocket fuel by increasing the number of ice formation and condensation centers, because they exhibit several mechanisms of action on atmospheric moisture. The synthesized hybrid powders meet the requirements of the regulatory documents in force in the Russian Federation

An ultrasensitive electrochemical immunosensor for carcinoembryonic antigen detection based on two-dimensional PtPd/Cu-TCPP(Fe) nanocomposites.

Establishing an effective signal amplification strategy is the key to achieving sensitive detection of analytes by electrochemical immunoassay. In this work, a novel sandwich-type electrochemical immunosensor with dual-signal amplification was successfully constructed using PtPd/Cu-TCPP(Fe) as the sensing platform and mesoporous silicon dioxide as the signal amplifier. Firstly, two-dimensional wrinkled Cu-TCPP(Fe) nanomaterials loaded with PtPd nanoparticles have strong affinity for the immobilization of capture antibodies and can generate excellent electrochemical signals. Meanwhile, the mesoporous silicon dioxide with large steric hindrance was used as signal label to further improve the sensitivity of the immunosensor by increasing the difference of the current response signal. Under optimal experimental conditions, the electrochemical immunosensor exhibited a wide linear detection range from 0.1pg/mL to 1.0μg/mL, with a detection limit as low as 0.166fg/mL. The experimental results showed that the constructed immunosensor has a great application prospect in clinical biomarker detection.

Folic acid-mediated MSNs@Ag@Geb multifunctional nanocomposite heterogeneous platform for combined therapy of non-small cell lung cancer

Molecularly targeted drugs are flourishing in the clinical treatment of non-small cell lung cancer (NSCLC). However, the treatment of a single drug (such as Gefitinib (Geb)) had defects such as poor pharmacokinetics, insufficient drug delivery, and considerable toxic side effects, which greatly affect its therapeutic efficacy against NSCLC. To solve these issues, this study developed a new nanocomposite heterogeneous platform (MSNs@Ag@Geb-FA) that combined photothermal therapy and molecular targeted therapy. The high specific surface area empowered mesoporous silicon dioxide (SiO2) heterostructure the ability to efficiently load Ag photothermal agents and anti-tumor drug Geb. Meanwhile, a favorable pH response (degradation of residual MnO2) achieved the controlled release of Ag and Geb. Besides, the targeting and endocytosis properties of nano drugs were greatly improved through the modification of folic acid (FA). Both in vivo and in vitro experiments authenticated that this nanocomposite heterogeneous platform could effectively integrate the multiple tumor suppressor properties of Ag nanoparticles and cooperate with Geb to hasten A549 cell apoptosis, thereby achieving a favorable anti-tumor effect. This heterogeneous structure of the nanocomposite heterogeneous platform could provide an effective strategy for the treatment of NSCLC.

Individual and Binary Mixture Toxicity of Five Nanoparticles in Marine Microalga Heterosigma akashiwo.

The investigation of the combined toxic action of different types of nanoparticles (NPs) and their interaction between each other and with aquatic organisms is an important problem of modern ecotoxicology. In this study, we assessed the individual and mixture toxicities of cadmium and zinc sulfides (CdS and ZnS), titanium dioxide (TiO2), and two types of mesoporous silicon dioxide (with no inclusions (SMB3) and with metal inclusions (SMB24)) by a microalga growth inhibition bioassay. The counting and size measurement of microalga cells and NPs were performed by flow cytometry. The biochemical endpoints were measured by a UV-VIS microplate spectrophotometer. The highest toxicity was observed for SMB24 (EC50, 3.6 mg/L) and CdS (EC50, 21.3 mg/L). A combined toxicity bioassay demonstrated that TiO2 and the SMB3 NPs had a synergistic toxic effect in combinations with all the tested samples except SMB24, probably caused by a “Trojan horse effect”. Sample SMB24 had antagonistic toxic action with CdS and ZnS, which was probably caused by metal ion scavenging.

ВПЛИВ РОЗМІРУ ПОР ТА МОРФОЛОГІЇ МЕЗОПОРИСТОГО КРЕМНІЮ НА ВИВІЛЬНЕННЯ МЕТОПРОЛОЛУ ТАРТРАТУ

Purpose. Study pore size effect and morphology of mesoporous silica on metoprolol tartrate release.Methodology. A sample of hollow mesoporous silicon dioxide with amino-functional groups containing 12.7 wt. % metoprolol tartrate has been investigated as potential carriers for the controlled release of active substance. Studies of the release profiles of metoprolol tartrate were performed under the following conditions: dissolution medium was buffer solution with a pH of 7.4 (phosphate buffer); sampling time: from 0.5 h before 18 h. The metoprolol concentration in the liquid phase was evaluated by a UV-Vis spectrophotometer (Persee TU-190, Beijing, China) by use of quartz cuvettes with an optical path length of 1 cm at a maximum wavelength of 274 nm.Findings. In this work we have studied mesoporous silica as possible carrier to controlled release of metoprolol tartrate, a drug used in the treatment of some diseases of the cardiovascular system. The material for research was a sample of hollow mesoporous silicon dioxide with amino-functional groups 200–400 nm in size and 20–30 nm in shell thickness. A calibrated curve to determine the amount of metoprolol was constructed by determining the absorption dependence of the concentration of metoprolol in the range from 10 to 300 ppm. The same drug concentration was obtained as calculated from the drug release test formula, which concludes that the release of metoprolol is controlled.Originality. The controlled release of a sample of hollow spheres of mesoporous silicon dioxide filled with metoprolol tartrate was studied, which was synthesized by the School of Chemistry and Chemical Engineering, Qilu University of Technology, using a new technology, where hollow spheres of mesoporous silicon dioxide with amino groups were synthesized using CO2 gas bubbles as templates.Practical value. The metoprolol release amount could achieve a 50% release amounts within 1 hour and 90% within 5 hours, indicating that the synthesized mesoporous hollow sphere could achieve controlled drug release, and shows the potential of carriers with stimulus response and targeted therapy.

Synthesis of mesoporous SiO2 nanoparticles and toxicity assessment in early life stages of zebrafish

Mesoporous nanoparticles (MNPs) have attracted great interest in the biomedical applications as reliable drug carriers for cancer treatment. They have significant advantages over the traditional drug carriers due to high surface area, controllable pore size, large pore volume, easy adjustment of the inner and outer surfaces, and also, high drug loading capacity. This work has focused on the synthesis of mesoporous silicon dioxide nanoparticles (MNPs) with different pore volumes and their toxicity effects on zebrafish. The structural and morphological analyses of MNPs were carried out through XRD and HRTEM, functional groups have been identified by FTIR and N2 adsorption/desorption isotherm and the pore size distribution was determined by BET analysis. The maximum pore volume of 1.5 cm3/g and a pore size of 8.0 nm, were reported. Survival percentage of zebrafish was reported to be above 85%.

Composite electrode material of MoO3‐MC‐SiO2‐PANI: Aqueous supercapacitor cell with high energy density, 1 V and 250,000 CD cycles

AbstractA synthesis of electrode material with higher‐energy density and more extended stability is very significant for replacing the present‐day supercapacitor demand. Toward this objective, in this work, a composite containing three primary materials meant for supercapacitor application is synthesized. They are conducting polymer, metal oxide, and carbon materials. A unique quaternary composite is prepared via the chemical method using mesoporous carbon (MC), polyaniline (PANI), molybdenum oxide (MoO3), and silicon dioxide (SiO2) materials. This composite is used as an electroactive material in symmetric electrode configuration in aqueous electrolyte supercapacitor. As synthesized MoO3‐MC‐SiO2‐PANI sample is subjected to 250,000 CD cycles at a higher discharge current density of 16.6 A/g with 57% retention of the initial capacitance of 45 F/g with low and constant equivalent series resistance (ESR) value (3–3.8 Ω). This composite showed an energy density (ED) as 31 Wh/Kg at a power density of 155 W/Kg. The excellent stability of the electrode material was established by evaluating the electrode material after the subjection of 250,000 CD cycles by Fourier‐transform infrared spectroscopy (FT‐IR), field emission scanning electron microscopy (FE‐SEM), energy dispersive spectroscopy (EDX), cyclic voltammetry (CV), galvanostatic charge–discharge (CD), and electrochemical impedance spectroscopy (EIS) measurements.

Antibacterial Effect of Thymol Loaded SBA-15 Nanorods Incorporated in PCL Electrospun Fibers.

For the effective management of infected chronic wounds, the incorporation of antimicrobial drugs into wound dressings can increase their local availability at the infection site. Mesoporous silicon dioxide SBA-15 is an excellent drug carrier with tunable drug release kinetics. In this work, synthesized SBA-15 loaded with the natural antimicrobial compound thymol (THY) was incorporated into polycaprolactone (PCL) electrospun nanofibers to obtain an advanced wound dressing. Rod-shaped particles with internal parallel channels oriented along the longitudinal axis (diameter: 138 ± 30 nm, length: 563 ± 100 nm) were loaded with 70.8 wt.% of THY. Fiber mats were prepared using these particles as nanofillers within polycaprolactone (PCL) electrospun fibers. The resulting mats contained 5.6 wt.% of THY and more than half of this loading was released in the first 7 h. This release would prevent an initial bacterial colonization and also inhibit or eliminate bacterial growth as in vitro shown against Staphylococcus aureus ATCC 25923. Minimal inhibitory concentration (MIC: 0.07 mg/mL) and minimal bactericidal concentration (MBC: 0.11 mg/mL) of released THY were lower than the amount of free THY required, demonstrating the benefit of drug encapsulation for a more efficient bactericidal capacity due to the direct contact between mats and bacteria.