A double network hydrogel dressing enhanced by catechin-loaded mesoporous silica for accelerating wound repair in conjunction with red-light therapy

Abstract

The process of healing wounds is an intricate mechanism that the human body undergoes. However, the production of hydrogel dressings is expensive and involves a complicated manufacturing procedure. Furthermore, most wound dressings lack bioactive components, limiting their ability to actively promote wound healing. To address this issue, we have developed an adhesive hydrogel dressing for wound repair that possesses antibacterial, anti-inflammatory and antioxidant capabilities. The dressing is composed of polyethylene glycol diacrylate (PEGDA), chitosan (CS), and catechin-loaded mesoporous silicon dioxide (CMSN). The hydrogel dressing adheres tightly to tissues through topological adhesion of CS macromolecules. At the same time, CMSN slowly releases the active substance, catechin, at the wound site. Moreover, the intermolecular interactions and hydrogen bonding between CMSN and PEGDA/CS hydrogels enhance the mechanical stability of the dressing. This allows for effective closure and repair of wounds, even in areas with frequent movement. Additionally, red-light therapy can be employed to further promote wound healing. It works by enhancing blood circulation, improving wound oxygenation, and stimulating collagen synthesis. When combined with the biocompatible and adhesive hydrogel dressing, it offers a promising approach for the rapid repair of wounds in motorial wounded areas.